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The polarized localization of lipoprotein receptors and cholesterol transporters in the syncytiotrophoblast of the placenta is reproducible in a monolayer of primary human trophoblasts.

Fuenzalida B, Kallol S, Lüthi M, Albrecht C, Leiva A. Fuenzalida B, et al. Among authors: leiva a. Placenta. 2021 Feb;105:50-60. doi: 10.1016/j.placenta.2021.01.019. Epub 2021 Jan 26. Placenta. 2021. PMID: 33548684

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Role of insulin and adenosine in the human placenta microvascular and macrovascular endothelial cell dysfunction in gestational diabetes mellitus.

Guzmán-Gutiérrez E, Arroyo P, Salsoso R, Fuenzalida B, Sáez T, Leiva A, Pardo F, Sobrevia L. Guzmán-Gutiérrez E, et al. Among authors: leiva a. Microcirculation. 2014 Jan;21(1):26-37. doi: 10.1111/micc.12077. Microcirculation. 2014. PMID: 23875992 Review.

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Insulin requires normal expression and signaling of insulin receptor A to reverse gestational diabetes-reduced adenosine transport in human umbilical vein endothelium.

Westermeier F, Salomón C, Farías M, Arroyo P, Fuenzalida B, Sáez T, Salsoso R, Sanhueza C, Guzmán-Gutiérrez E, Pardo F, Leiva A, Sobrevia L. Westermeier F, et al. Among authors: leiva a. FASEB J. 2015 Jan;29(1):37-49. doi: 10.1096/fj.14-254219. Epub 2014 Oct 28. FASEB J. 2015. PMID: 25351985

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Role for Tetrahydrobiopterin in the Fetoplacental Endothelial Dysfunction in Maternal Supraphysiological Hypercholesterolemia.

Leiva A, Fuenzalida B, Westermeier F, Toledo F, Salomón C, Gutiérrez J, Sanhueza C, Pardo F, Sobrevia L. Leiva A, et al. Oxid Med Cell Longev. 2015;2015:5346327. doi: 10.1155/2016/5346327. Epub 2015 Nov 30. Oxid Med Cell Longev. 2015. PMID: 26697136 Free PMC article. Review.

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Tetrahydrobiopterin Role in human umbilical vein endothelial dysfunction in maternal supraphysiological hypercholesterolemia.

Leiva A, Fuenzalida B, Salsoso R, Barros E, Toledo F, Gutiérrez J, Pardo F, Sobrevia L. Leiva A, et al. Biochim Biophys Acta. 2016 Apr;1862(4):536-544. doi: 10.1016/j.bbadis.2016.01.021. Epub 2016 Jan 26. Biochim Biophys Acta. 2016. PMID: 26826019 Free article.

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Nitric Oxide is a Central Common Metabolite in Vascular Dysfunction Associated with Diseases of Human Pregnancy.

Leiva A, Fuenzalida B, Barros E, Sobrevia B, Salsoso R, Sáez T, Villalobos R, Silva L, Chiarello I, Toledo F, Gutiérrez J, Sanhueza C, Pardo F, Sobrevia L. Leiva A, et al. Curr Vasc Pharmacol. 2016;14(3):237-59. doi: 10.2174/1570161114666160222115158. Curr Vasc Pharmacol. 2016. PMID: 26899560 Review.

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Insulin Is a Key Modulator of Fetoplacental Endothelium Metabolic Disturbances in Gestational Diabetes Mellitus.

Sobrevia L, Salsoso R, Fuenzalida B, Barros E, Toledo L, Silva L, Pizarro C, Subiabre M, Villalobos R, Araos J, Toledo F, González M, Gutiérrez J, Farías M, Chiarello DI, Pardo F, Leiva A. Sobrevia L, et al. Among authors: leiva a. Front Physiol. 2016 Mar 31;7:119. doi: 10.3389/fphys.2016.00119. eCollection 2016. Front Physiol. 2016. PMID: 27065887 Free PMC article. Review.

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Intracellular and extracellular pH dynamics in the human placenta from diabetes mellitus.

Araos J, Silva L, Salsoso R, Sáez T, Barros E, Toledo F, Gutiérrez J, Pardo F, Leiva A, Sanhueza C, Sobrevia L. Araos J, et al. Among authors: leiva a. Placenta. 2016 Jul;43:47-53. doi: 10.1016/j.placenta.2016.05.003. Epub 2016 May 7. Placenta. 2016. PMID: 27324099 Review.

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Adenosine receptors: Modulators of lipid availability that are controlled by lipid levels.

Leiva A, Guzmán-Gutiérrez E, Contreras-Duarte S, Fuenzalida B, Cantin C, Carvajal L, Salsoso R, Gutiérrez J, Pardo F, Sobrevia L. Leiva A, et al. Mol Aspects Med. 2017 Jun;55:26-44. doi: 10.1016/j.mam.2017.01.007. Epub 2017 Jan 31. Mol Aspects Med. 2017. PMID: 28153452 Review.

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Akt/mTOR Role in Human Foetoplacental Vascular Insulin Resistance in Diseases of Pregnancy.

Villalobos-Labra R, Silva L, Subiabre M, Araos J, Salsoso R, Fuenzalida B, Sáez T, Toledo F, González M, Quezada C, Pardo F, Chiarello DI, Leiva A, Sobrevia L. Villalobos-Labra R, et al. Among authors: leiva a. J Diabetes Res. 2017;2017:5947859. doi: 10.1155/2017/5947859. Epub 2017 Sep 14. J Diabetes Res. 2017. PMID: 29104874 Free PMC article. Review.

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