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The effect of curcumin and placebo on human gall-bladder function: an ultrasound study.
Rasyid A, Lelo A. Rasyid A, et al. Among authors: lelo a. Aliment Pharmacol Ther. 1999 Feb;13(2):245-9. doi: 10.1046/j.1365-2036.1999.00464.x. Aliment Pharmacol Ther. 1999. PMID: 10102956 Clinical Trial.
BACKGROUND: The extract of medicinal plants containing curcumin is traditionally believed to have a positive contraction effect on the human gall-bladder. ...METHODS: A randomized, double blind and crossover design study was carried out in 12 healthy volunteers (sev …
BACKGROUND: The extract of medicinal plants containing curcumin is traditionally believed to have a positive contraction effect on th …
Effect of different curcumin dosages on human gall bladder.
Rasyid A, Rahman AR, Jaalam K, Lelo A. Rasyid A, et al. Among authors: lelo a. Asia Pac J Clin Nutr. 2002;11(4):314-8. doi: 10.1046/j.1440-6047.2002.00296.x. Asia Pac J Clin Nutr. 2002. PMID: 12495265 Clinical Trial.
Our previous study demonstrated that curcumin, an active compound of Curcuma xanthorrhiza and C. domestica, produces a positive cholekinetic effect. A 20 mg amount of curcumin is capable of contracting the gall bladder by up to 29% within an observation time of 2 h. …
Our previous study demonstrated that curcumin, an active compound of Curcuma xanthorrhiza and C. domestica, produces a positive chole …
Correlations between Insulin Receptor Substrate-1 with Phosphoinositide 3-Kinase and P38 Mitogen-Activated Protein Kinase Levels after Treatment of Diabetic Rats with Puguntano (Curanga Fel-Terrae [Merr.]) Leaf Extract.
Syafril S, Lindarto D, Lelo A, Sembiring RJ, Saragih A. Syafril S, et al. Among authors: lelo a. Open Access Maced J Med Sci. 2019 Apr 23;7(8):1247-1251. doi: 10.3889/oamjms.2019.218. eCollection 2019 Apr 30. Open Access Maced J Med Sci. 2019. PMID: 31110564 Free PMC article.
AIM: This study aimed to investigate the correlations between insulin receptor substrate (IRS)-1 with phosphoinositide 3-kinase (PI3K) and p38 mitogen-activated protein kinase (MAPK) levels after puguntano (Curanga fel-terrae [Merr.]) leaf extract treatment in a rat model …
AIM: This study aimed to investigate the correlations between insulin receptor substrate (IRS)-1 with phosphoinositide 3-kinase (PI3K) and p …
Increasing Atherosclerosis in Streptozotocin-Induced Diabetes into Four Groups of Mice.
Ritarwan K, Lelo A, Pane YS, Nerdy N. Ritarwan K, et al. Among authors: lelo a. Open Access Maced J Med Sci. 2018 Feb 14;6(2):287-292. doi: 10.3889/oamjms.2018.093. eCollection 2018 Feb 15. Open Access Maced J Med Sci. 2018. PMID: 29531590 Free PMC article.
The Effect of Puguntano Leaf Extract (Curanga Fel - Terrae Merr.) On P38 Mapk Levels and Glut-4 Expression in Type 2 Diabetic Rat Muscle.
Syafril S, Lindarto D, Lelo A, Sembiring RJ, Manaf A, Putra IB, Hasibuan PAZ, Mutiara E. Syafril S, et al. Among authors: lelo a. Open Access Maced J Med Sci. 2019 Feb 26;7(4):521-525. doi: 10.3889/oamjms.2019.165. eCollection 2019 Feb 28. Open Access Maced J Med Sci. 2019. PMID: 30894905 Free PMC article.
METHODS: Forty-eight male Wistar rats had T2DM induced using a combination of feeding a high-fat diet for 5 weeks and multiple intraperitoneal injections of low-dose streptozotocin (30 mg/kg). ...CONCLUSION: These data suggest that a puguntano leaf extract ca …
METHODS: Forty-eight male Wistar rats had T2DM induced using a combination of feeding a high-fat diet for 5 weeks and multiple …
A genetic study of steroid-resistant nephrotic syndrome: relationship between polymorphism -173 G to C in the MIF gene and serum level MIF in children.
Ramayani OR, Sekarwana N, Trihono PP, Sadewa AH, Lelo A. Ramayani OR, et al. Among authors: lelo a. J Dev Orig Health Dis. 2016 Feb;7(1):102-7. doi: 10.1017/S2040174415007850. Epub 2015 Nov 6. J Dev Orig Health Dis. 2016. PMID: 26541175
Children were defined as healthy when they had a normal estimated glomerular filtration rate and spot urinary albumin creatinine ratio <150 μg/mg creatinine. ...There was a trend toward an association between genotypes and serum MIF disturbances. In conclusion, t …
Children were defined as healthy when they had a normal estimated glomerular filtration rate and spot urinary albumin creatinine rati …
Paraxanthine metabolism in humans: determination of metabolic partial clearances and effects of allopurinol and cimetidine.
Lelo A, Kjellen G, Birkett DJ, Miners JO. Lelo A, et al. J Pharmacol Exp Ther. 1989 Jan;248(1):315-9. J Pharmacol Exp Ther. 1989. PMID: 2913277
Despite the continuous exposure of a large proportion of the population to PX, little is known about PX disposition in humans. ...These data are consistent with 1-MX and AFMU being derived from a common intermediate, the formation of which is mediated by cytochrome …
Despite the continuous exposure of a large proportion of the population to PX, little is known about PX disposition in humans. ...The …
Biochemical validation of self-reported caffeine consumption during caffeine fading.
James JE, Paull I, Cameron-Traub E, Miners JO, Lelo A, Birkett DJ. James JE, et al. Among authors: lelo a. J Behav Med. 1988 Feb;11(1):15-30. doi: 10.1007/BF00846166. J Behav Med. 1988. PMID: 3367369
Increasing concern about caffeine as a drug with potential for abuse has resulted in the development of procedures for effecting reductions in caffeine consumption among heavy users. ...The present study employed bioanalytic methods for assessing the reliability of self-re …
Increasing concern about caffeine as a drug with potential for abuse has resulted in the development of procedures for effecting redu …
Assessment of caffeine exposure: caffeine content of beverages, caffeine intake, and plasma concentrations of methylxanthines.
Lelo A, Miners JO, Robson R, Birkett DJ. Lelo A, et al. Clin Pharmacol Ther. 1986 Jan;39(1):54-9. doi: 10.1038/clpt.1986.10. Clin Pharmacol Ther. 1986. PMID: 3943270
The number of drinks of coffee and tea consumed was a poor index of actual caffeine intake (r2 = 0.42). Caffeine intake correlated poorly with the 24-hour average caffeine concentration (r2 = 0.41), but there was a very good correlation between a single plasm …
The number of drinks of coffee and tea consumed was a poor index of actual caffeine intake (r2 = 0.42). Caffeine intake correlated po …
Radiometric high-performance liquid chromatographic procedure for the determination of theobromine metabolites in microsomal incubations.
Lelo A, Birkett DJ, Miners JO. Lelo A, et al. J Chromatogr. 1988 Aug 19;430(1):203-6. doi: 10.1016/s0378-4347(00)83154-0. J Chromatogr. 1988. PMID: 3215959 No abstract available.
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