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STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockade.
Fu J, Kanne DB, Leong M, Glickman LH, McWhirter SM, Lemmens E, Mechette K, Leong JJ, Lauer P, Liu W, Sivick KE, Zeng Q, Soares KC, Zheng L, Portnoy DA, Woodward JJ, Pardoll DM, Dubensky TW Jr, Kim Y. Fu J, et al. Among authors: lemmens e. Sci Transl Med. 2015 Apr 15;7(283):283ra52. doi: 10.1126/scitranslmed.aaa4306. Sci Transl Med. 2015. PMID: 25877890 Free PMC article.
Recombinant Listeria promotes tumor rejection by CD8+ T cell-dependent remodeling of the tumor microenvironment.
Deng W, Lira V, Hudson TE, Lemmens EE, Hanson WG, Flores R, Barajas G, Katibah GE, Desbien AL, Lauer P, Leong ML, Portnoy DA, Dubensky TW Jr. Deng W, et al. Among authors: lemmens ee. Proc Natl Acad Sci U S A. 2018 Aug 7;115(32):8179-8184. doi: 10.1073/pnas.1801910115. Epub 2018 Jul 23. Proc Natl Acad Sci U S A. 2018. PMID: 30038013 Free PMC article.
A Potent and Effective Suicidal Listeria Vaccine Platform.
Hanson WG, Benanti EL, Lemmens EE, Liu W, Skoble J, Leong ML, Rae CS, Fassò M, Brockstedt DG, Chen C, Portnoy DA, Dubensky TW Jr, Lauer P. Hanson WG, et al. Among authors: lemmens ee. Infect Immun. 2019 Jul 23;87(8):e00144-19. doi: 10.1128/IAI.00144-19. Print 2019 Aug. Infect Immun. 2019. PMID: 31235641 Free PMC article.
Cytosolic entry controls CD8+-T-cell potency during bacterial infection.
Bahjat KS, Liu W, Lemmens EE, Schoenberger SP, Portnoy DA, Dubensky TW Jr, Brockstedt DG. Bahjat KS, et al. Among authors: lemmens ee. Infect Immun. 2006 Nov;74(11):6387-97. doi: 10.1128/IAI.01088-06. Epub 2006 Sep 5. Infect Immun. 2006. PMID: 16954391 Free PMC article.
Constitutive Activation of the PrfA regulon enhances the potency of vaccines based on live-attenuated and killed but metabolically active Listeria monocytogenes strains.
Lauer P, Hanson B, Lemmens EE, Liu W, Luckett WS, Leong ML, Allen HE, Skoble J, Bahjat KS, Freitag NE, Brockstedt DG, Dubensky TW Jr. Lauer P, et al. Among authors: lemmens ee. Infect Immun. 2008 Aug;76(8):3742-53. doi: 10.1128/IAI.00390-08. Epub 2008 Jun 9. Infect Immun. 2008. PMID: 18541651 Free PMC article.
Safety and survival with GVAX pancreas prime and Listeria Monocytogenes-expressing mesothelin (CRS-207) boost vaccines for metastatic pancreatic cancer.
Le DT, Wang-Gillam A, Picozzi V, Greten TF, Crocenzi T, Springett G, Morse M, Zeh H, Cohen D, Fine RL, Onners B, Uram JN, Laheru DA, Lutz ER, Solt S, Murphy AL, Skoble J, Lemmens E, Grous J, Dubensky T Jr, Brockstedt DG, Jaffee EM. Le DT, et al. Among authors: lemmens e. J Clin Oncol. 2015 Apr 20;33(12):1325-33. doi: 10.1200/JCO.2014.57.4244. Epub 2015 Jan 12. J Clin Oncol. 2015. PMID: 25584002 Free PMC article. Clinical Trial.
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