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Page 1
Mitochondria shed their outer membrane in response to infection-induced stress.
Li X, Straub J, Medeiros TC, Mehra C, den Brave F, Peker E, Atanassov I, Stillger K, Michaelis JB, Burbridge E, Adrain C, Münch C, Riemer J, Becker T, Pernas LF. Li X, et al. Among authors: pernas lf. Science. 2022 Jan 14;375(6577):eabi4343. doi: 10.1126/science.abi4343. Epub 2022 Jan 14. Science. 2022. PMID: 35025629
Mitochondria protect against an intracellular pathogen by restricting access to folate.
Medeiros TC, Ovciarikova J, Li X, Krueger P, Bartsch T, Reato S, Crow JC, Tellez Sutterlin M, Martins Garcia B, Rais I, Allmeroth K, Hartman MD, Denzel MS, Purrio M, Mesaros A, Leung KY, Greene NDE, Sheiner L, Giavalisco P, Pernas L. Medeiros TC, et al. Among authors: pernas l. Science. 2025 Aug 14;389(6761):eadr6326. doi: 10.1126/science.adr6326. Epub 2025 Aug 14. Science. 2025. PMID: 40811546 Free PMC article.
The mitochondrial protein Opa1 promotes adipocyte browning that is dependent on urea cycle metabolites.
Bean C, Audano M, Varanita T, Favaretto F, Medaglia M, Gerdol M, Pernas L, Stasi F, Giacomello M, Herkenne S, Muniandy M, Heinonen S, Cazaly E, Ollikainen M, Milan G, Pallavicini A, Pietiläinen KH, Vettor R, Mitro N, Scorrano L. Bean C, et al. Among authors: pernas l. Nat Metab. 2021 Dec;3(12):1633-1647. doi: 10.1038/s42255-021-00497-2. Epub 2021 Dec 6. Nat Metab. 2021. PMID: 34873337 Free article.
Glutamine sensing licenses cholesterol synthesis.
Garcia BM, Melchinger P, Medeiros T, Hendrix S, Prabhu K, Corrado M, Kingma J, Gorbatenko A, Deshwal S, Veronese M, Scorrano L, Pearce E, Giavalisco P, Zelcer N, Pernas L. Garcia BM, et al. Among authors: pernas l. EMBO J. 2024 Dec;43(23):5837-5856. doi: 10.1038/s44318-024-00269-0. Epub 2024 Oct 21. EMBO J. 2024. PMID: 39433901 Free PMC article.
Metabolic immunity against microbes.
Kreimendahl S, Pernas L. Kreimendahl S, et al. Among authors: pernas l. Trends Cell Biol. 2024 Jun;34(6):496-508. doi: 10.1016/j.tcb.2023.10.013. Epub 2023 Nov 29. Trends Cell Biol. 2024. PMID: 38030541 Free article. Review.
Mitochondria as sensors of intracellular pathogens.
Delgado JM, Pernas L. Delgado JM, et al. Among authors: pernas l. Trends Endocrinol Metab. 2025 Jul;36(7):638-644. doi: 10.1016/j.tem.2024.10.009. Epub 2024 Nov 22. Trends Endocrinol Metab. 2025. PMID: 39580272 Review.
Contact and competition between mitochondria and microbes.
Medeiros TC, Mehra C, Pernas L. Medeiros TC, et al. Among authors: pernas l. Curr Opin Microbiol. 2021 Oct;63:189-194. doi: 10.1016/j.mib.2021.07.014. Epub 2021 Aug 16. Curr Opin Microbiol. 2021. PMID: 34411806 Review.
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