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Insulin signaling defects in type 2 diabetes.
Leng Y, Karlsson HK, Zierath JR. Leng Y, et al. Rev Endocr Metab Disord. 2004 May;5(2):111-7. doi: 10.1023/B:REMD.0000021432.84588.f6. Rev Endocr Metab Disord. 2004. PMID: 15041786 Review. No abstract available.
Downregulation of diacylglycerol kinase delta contributes to hyperglycemia-induced insulin resistance.
Chibalin AV, Leng Y, Vieira E, Krook A, Björnholm M, Long YC, Kotova O, Zhong Z, Sakane F, Steiler T, Nylén C, Wang J, Laakso M, Topham MK, Gilbert M, Wallberg-Henriksson H, Zierath JR. Chibalin AV, et al. Among authors: leng y. Cell. 2008 Feb 8;132(3):375-86. doi: 10.1016/j.cell.2007.12.035. Cell. 2008. PMID: 18267070
Role of AMP kinase and PPARdelta in the regulation of lipid and glucose metabolism in human skeletal muscle.
Krämer DK, Al-Khalili L, Guigas B, Leng Y, Garcia-Roves PM, Krook A. Krämer DK, et al. Among authors: leng y. J Biol Chem. 2007 Jul 6;282(27):19313-20. doi: 10.1074/jbc.M702329200. Epub 2007 May 11. J Biol Chem. 2007. PMID: 17500064 Clinical Trial.
Changes in exercise-induced gene expression in 5'-AMP-activated protein kinase gamma3-null and gamma3 R225Q transgenic mice.
Barnes BR, Long YC, Steiler TL, Leng Y, Galuska D, Wojtaszewski JF, Andersson L, Zierath JR. Barnes BR, et al. Among authors: leng y. Diabetes. 2005 Dec;54(12):3484-9. doi: 10.2337/diabetes.54.12.3484. Diabetes. 2005. PMID: 16306365
The 5'-AMP-activated protein kinase gamma3 isoform has a key role in carbohydrate and lipid metabolism in glycolytic skeletal muscle.
Barnes BR, Marklund S, Steiler TL, Walter M, Hjälm G, Amarger V, Mahlapuu M, Leng Y, Johansson C, Galuska D, Lindgren K, Abrink M, Stapleton D, Zierath JR, Andersson L. Barnes BR, et al. Among authors: leng y. J Biol Chem. 2004 Sep 10;279(37):38441-7. doi: 10.1074/jbc.M405533200. Epub 2004 Jul 6. J Biol Chem. 2004. PMID: 15247217
Effects of insulin, contraction, and phorbol esters on mitogen-activated protein kinase signaling in skeletal muscle from lean and ob/ob mice.
Leng Y, Steiler TL, Zierath JR. Leng Y, et al. Diabetes. 2004 Jun;53(6):1436-44. doi: 10.2337/diabetes.53.6.1436. Diabetes. 2004. PMID: 15161746
Effect of hyperglycemia on signal transduction in skeletal muscle from diabetic Goto-Kakizaki rats.
Steiler TL, Galuska D, Leng Y, Chibalin AV, Gilbert M, Zierath JR. Steiler TL, et al. Among authors: leng y. Endocrinology. 2003 Dec;144(12):5259-67. doi: 10.1210/en.2003-0447. Epub 2003 Aug 21. Endocrinology. 2003. PMID: 12960081
Role of AMP-activated protein kinase in the coordinated expression of genes controlling glucose and lipid metabolism in mouse white skeletal muscle.
Long YC, Barnes BR, Mahlapuu M, Steiler TL, Martinsson S, Leng Y, Wallberg-Henriksson H, Andersson L, Zierath JR. Long YC, et al. Among authors: leng y. Diabetologia. 2005 Nov;48(11):2354-64. doi: 10.1007/s00125-005-1962-5. Epub 2005 Oct 20. Diabetologia. 2005. PMID: 16237515
Effect of a novel non-thiazolidinedione peroxisome proliferator-activated receptor alpha/gamma agonist on glucose uptake.
Hu X, Feng Y, Liu X, Zhao XF, Yu JH, Yang YS, Sydow-Bäckman M, Hörling J, Zierath JR, Leng Y. Hu X, et al. Among authors: leng y. Diabetologia. 2007 May;50(5):1048-57. doi: 10.1007/s00125-007-0622-3. Epub 2007 Mar 1. Diabetologia. 2007. PMID: 17333104
Antidiabetic effect of a novel non-thiazolidinedione PPAR gamma/alpha agonist on ob/ob mice.
Hu X, Feng Y, Shen Y, Zhao XF, Yu JH, Yang YS, Leng Y. Hu X, et al. Among authors: leng y. Acta Pharmacol Sin. 2006 Oct;27(10):1346-52. doi: 10.1111/j.1745-7254.2006.00427.x. Acta Pharmacol Sin. 2006. PMID: 17007742
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