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Gadolinium-based contrast agents and their potential role in the pathogenesis of nephrogenic systemic fibrosis: the role of excess ligand.
Sieber MA, Lengsfeld P, Walter J, Schirmer H, Frenzel T, Siegmund F, Weinmann HJ, Pietsch H. Sieber MA, et al. J Magn Reson Imaging. 2008 May;27(5):955-62. doi: 10.1002/jmri.21368. J Magn Reson Imaging. 2008. PMID: 18425843
Preclinical investigation to compare different gadolinium-based contrast agents regarding their propensity to release gadolinium in vivo and to trigger nephrogenic systemic fibrosis-like lesions.
Sieber MA, Lengsfeld P, Frenzel T, Golfier S, Schmitt-Willich H, Siegmund F, Walter J, Weinmann HJ, Pietsch H. Sieber MA, et al. Eur Radiol. 2008 Oct;18(10):2164-73. doi: 10.1007/s00330-008-0977-y. Epub 2008 Jun 11. Eur Radiol. 2008. PMID: 18545998
Comparison of 1.0 M gadobutrol and 0.5 M gadopentate dimeglumine-enhanced MRI in 471 patients with known or suspected renal lesions: results of a multicenter, single-blind, interindividual, randomized clinical phase III trial.
Tombach B, Bohndorf K, Brodtrager W, Claussen CD, Düber C, Galanski M, Grabbe E, Gortenuti G, Kuhn M, Gross-Fengels W, Hammerstingl R, Happel B, Heinz-Peer G, Jung G, Kittner T, Lagalla R, Lengsfeld P, Loose R, Oyen RH, Pavlica P, Pering C, Pozzi-Mucelli R, Persigehl T, Reimer P, Renken NS, Richter GM, Rummeny EJ, Schäfer F, Szczerbo-Trojanowska M, Urbanik A, Vogl TJ, Hajek P. Tombach B, et al. Eur Radiol. 2008 Nov;18(11):2610-9. doi: 10.1007/s00330-008-1054-2. Epub 2008 Jul 8. Eur Radiol. 2008. PMID: 18607594 Clinical Trial.
Retention of iodine and expression of biomarkers for renal damage in the kidney after application of iodinated contrast media in rats.
Jost G, Pietsch H, Sommer J, Sandner P, Lengsfeld P, Seidensticker P, Lehr S, Hütter J, Sieber MA. Jost G, et al. Invest Radiol. 2009 Feb;44(2):114-23. doi: 10.1097/RLI.0b013e318190fbd2. Invest Radiol. 2009. PMID: 19104440
Absolute quantification of regional renal blood flow in swine by dynamic contrast-enhanced magnetic resonance imaging using a blood pool contrast agent.
Lüdemann L, Nafz B, Elsner F, Grosse-Siestrup C, Meissler M, Kaufels N, Rehbein H, Persson PB, Michaely HJ, Lengsfeld P, Voth M, Gutberlet M. Lüdemann L, et al. Invest Radiol. 2009 Mar;44(3):125-34. doi: 10.1097/RLI.0b013e318193598c. Invest Radiol. 2009. PMID: 19151609

The reduced kidney perfusion measured by ultrasound highly correlated with total renal blood flow determined by DCE-MRI, P < 0.001. ...Regional cortical and medullary renal flow was also highly correlated (r = 0.77/0.78, P < 0.001) with the degree of flow redu

The reduced kidney perfusion measured by ultrasound highly correlated with total renal blood flow determined by DCE-MRI, P < 0.001

Impact of renal impairment on long-term retention of gadolinium in the rodent skin following the administration of gadolinium-based contrast agents.
Pietsch H, Lengsfeld P, Steger-Hartmann T, Löwe A, Frenzel T, Hütter J, Sieber MA. Pietsch H, et al. Invest Radiol. 2009 Apr;44(4):226-33. doi: 10.1097/RLI.0b013e3181998eb7. Invest Radiol. 2009. PMID: 19252439
Skin biopsies were taken at various time points, and the gadolinium (Gd) concentration was determined by inductive coupled plasma mass spectrometry (ICP-MS) over an observation period of 168 days post injection (p.i.). ...For the nonionic linear compounds, Omniscan and Opt …
Skin biopsies were taken at various time points, and the gadolinium (Gd) concentration was determined by inductive coupled plasma mass spect …
Evaluating the role of zinc in the occurrence of fibrosis of the skin: a preclinical study.
Pietsch H, Pering C, Lengsfeld P, Walter J, Steger-Hartmann T, Golfier S, Frenzel T, Hütter J, Weinmann HJ, Sieber MA. Pietsch H, et al. J Magn Reson Imaging. 2009 Aug;30(2):374-83. doi: 10.1002/jmri.21845. J Magn Reson Imaging. 2009. PMID: 19629978
The influence of x-ray contrast agents in computed tomography on the induction of dicentrics and gamma-H2AX foci in lymphocytes of human blood samples.
Jost G, Golfier S, Pietsch H, Lengsfeld P, Voth M, Schmid TE, Eckardt-Schupp F, Schmid E. Jost G, et al. Phys Med Biol. 2009 Oct 21;54(20):6029-39. doi: 10.1088/0031-9155/54/20/001. Epub 2009 Sep 24. Phys Med Biol. 2009. PMID: 19779223
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