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Histone modification patterns and epigenetic codes.
Lennartsson A, Ekwall K. Lennartsson A, et al. Biochim Biophys Acta. 2009 Sep;1790(9):863-8. doi: 10.1016/j.bbagen.2008.12.006. Epub 2009 Jan 8. Biochim Biophys Acta. 2009. PMID: 19168116 Review.
Prognostic DNA methylation patterns in cytogenetically normal acute myeloid leukemia are predefined by stem cell chromatin marks.
Deneberg S, Guardiola P, Lennartsson A, Qu Y, Gaidzik V, Blanchet O, Karimi M, Bengtzén S, Nahi H, Uggla B, Tidefelt U, Höglund M, Paul C, Ekwall K, Döhner K, Lehmann S. Deneberg S, et al. Among authors: lennartsson a. Blood. 2011 Nov 17;118(20):5573-82. doi: 10.1182/blood-2011-01-332353. Epub 2011 Sep 29. Blood. 2011. PMID: 21960591
Aberrant DNA methylation is a hallmark of cancer, including AML. We investigated in total 118 CN-AML samples in a test and a validation cohort for genome-wide promoter DNA methylation with Illumina Methylation Bead arrays and compared them with normal myeloid …
Aberrant DNA methylation is a hallmark of cancer, including AML. We investigated in total 118 CN-AML samples in a test and …
High-throughput transcription profiling identifies putative epigenetic regulators of hematopoiesis.
Prasad P, Rönnerblad M, Arner E, Itoh M, Kawaji H, Lassmann T, Daub CO, Forrest AR, Lennartsson A, Ekwall K; FANTOM consortium. Prasad P, et al. Among authors: lennartsson a. Blood. 2014 Apr 24;123(17):e46-57. doi: 10.1182/blood-2013-02-483537. Epub 2014 Mar 26. Blood. 2014. PMID: 24671951
Hematopoietic differentiation is governed by a complex regulatory program controlling the generation of different lineages of blood cells from multipotent hematopoietic stem cells. ...This analysis could serve as a resource for the scientific community for further c …
Hematopoietic differentiation is governed by a complex regulatory program controlling the generation of different lineages of blood c …
Analysis of the DNA methylome and transcriptome in granulopoiesis reveals timed changes and dynamic enhancer methylation.
Rönnerblad M, Andersson R, Olofsson T, Douagi I, Karimi M, Lehmann S, Hoof I, de Hoon M, Itoh M, Nagao-Sato S, Kawaji H, Lassmann T, Carninci P, Hayashizaki Y, Forrest AR, Sandelin A, Ekwall K, Arner E, Lennartsson A; FANTOM consortium. Rönnerblad M, et al. Among authors: lennartsson a. Blood. 2014 Apr 24;123(17):e79-89. doi: 10.1182/blood-2013-02-482893. Epub 2014 Mar 26. Blood. 2014. PMID: 24671952
In development, epigenetic mechanisms such as DNA methylation have been suggested to provide a cellular memory to maintain multipotency but also stabilize cell fate decisions and direct lineage restriction. ...Overall, this study depicts in detail the epigenetic and transc …
In development, epigenetic mechanisms such as DNA methylation have been suggested to provide a cellular memory to maintain multipoten …
microRNA-34b/c on chromosome 11q23 is aberrantly methylated in chronic lymphocytic leukemia.
Deneberg S, Kanduri M, Ali D, Bengtzen S, Karimi M, Qu Y, Kimby E, Mansouri L, Rosenquist R, Lennartsson A, Lehmann S. Deneberg S, et al. Among authors: lennartsson a. Epigenetics. 2014 Jun;9(6):910-7. doi: 10.4161/epi.28603. Epub 2014 Mar 31. Epigenetics. 2014. PMID: 24686393 Free PMC article.
A microRNA (miR) cluster including the miR-34b and miR-34c genes is located, among other genes, within the commonly deleted region (CDR) at 11q. ...Altogether, our novel data suggest that miR-34b/c is a candidate tumor suppressor that is epigenetically silenced in C
A microRNA (miR) cluster including the miR-34b and miR-34c genes is located, among other genes, within the commonly deleted region (C
Transcription-coupled recruitment of human CHD1 and CHD2 influences chromatin accessibility and histone H3 and H3.3 occupancy at active chromatin regions.
Siggens L, Cordeddu L, Rönnerblad M, Lennartsson A, Ekwall K. Siggens L, et al. Among authors: lennartsson a. Epigenetics Chromatin. 2015 Jan 15;8(1):4. doi: 10.1186/1756-8935-8-4. eCollection 2015. Epigenetics Chromatin. 2015. PMID: 25621013 Free PMC article.
At a molecular level, the mechanisms are not fully understood but include transcriptional regulation, nucleosome organization and turnover. ...
At a molecular level, the mechanisms are not fully understood but include transcriptional regulation, nucleosome organization and tur …
The roles of SNF2/SWI2 nucleosome remodeling enzymes in blood cell differentiation and leukemia.
Prasad P, Lennartsson A, Ekwall K. Prasad P, et al. Among authors: lennartsson a. Biomed Res Int. 2015;2015:347571. doi: 10.1155/2015/347571. Epub 2015 Feb 19. Biomed Res Int. 2015. PMID: 25789315 Free PMC article. Review.
However, blood cells express a limited set of SNF2 ATPases that are necessary to maintain the pool of hematopoietic stem cells (HSCs) and drive normal blood cell development and differentiation. ...
However, blood cells express a limited set of SNF2 ATPases that are necessary to maintain the pool of hematopoietic stem cells (HSCs) …
Epigenetic aberrations in acute myeloid leukemia: Early key events during leukemogenesis.
Eriksson A, Lennartsson A, Lehmann S. Eriksson A, et al. Among authors: lennartsson a. Exp Hematol. 2015 Aug;43(8):609-24. doi: 10.1016/j.exphem.2015.05.009. Epub 2015 Jun 26. Exp Hematol. 2015. PMID: 26118500 Review.
As a result of the introduction of new sequencing technologies, the molecular landscape of acute myeloid leukemia (AML) is rapidly evolving. ...This has revealed a new complex landscape of genetic aberrations where addition of mutations in epigenetic regulators has …
As a result of the introduction of new sequencing technologies, the molecular landscape of acute myeloid leukemia (AML) is rapidly ev …
EpiFactors: a comprehensive database of human epigenetic factors and complexes.
Medvedeva YA, Lennartsson A, Ehsani R, Kulakovskiy IV, Vorontsov IE, Panahandeh P, Khimulya G, Kasukawa T; FANTOM Consortium, Drabløs F. Medvedeva YA, et al. Among authors: lennartsson a. Database (Oxford). 2015 Jul 7;2015:bav067. doi: 10.1093/database/bav067. Print 2015. Database (Oxford). 2015. PMID: 26153137 Free PMC article.
Here we present EpiFactors, a manually curated database providing information about epigenetic regulators, their complexes, targets and products. ...The resource is practical for a wide range of users, including biologists, pharmacologists and clinicians....
Here we present EpiFactors, a manually curated database providing information about epigenetic regulators, their complexes, targets a …
Remodeling of retrotransposon elements during epigenetic induction of adult visual cortical plasticity by HDAC inhibitors.
Lennartsson A, Arner E, Fagiolini M, Saxena A, Andersson R, Takahashi H, Noro Y, Sng J, Sandelin A, Hensch TK, Carninci P. Lennartsson A, et al. Epigenetics Chromatin. 2015 Dec 14;8:55. doi: 10.1186/s13072-015-0043-3. eCollection 2015. Epigenetics Chromatin. 2015. PMID: 26673794 Free PMC article.
RESULTS: We found that VPA reliably reactivates the critical period plasticity and induces a dramatic change of chromatin organization in V1 yielding significantly greater accessibility distant from promoters, including at enhancer regions. ...
RESULTS: We found that VPA reliably reactivates the critical period plasticity and induces a dramatic change of chromatin organizatio …
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