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2002 1
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2020 3
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28 results
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Page 1
A perturbed ubiquitin landscape distinguishes between ubiquitin in trafficking and in proteolysis.
Ziv I, Matiuhin Y, Kirkpatrick DS, Erpapazoglou Z, Leon S, Pantazopoulou M, Kim W, Gygi SP, Haguenauer-Tsapis R, Reis N, Glickman MH, Kleifeld O. Ziv I, et al. Among authors: leon s. Mol Cell Proteomics. 2011 May;10(5):M111.009753. doi: 10.1074/mcp.M111.009753. Epub 2011 Mar 22. Mol Cell Proteomics. 2011. PMID: 21427232 Free PMC article.
In vivo expression of lysineless ubiquitin (K0 Ub) perturbed the ubiquitin landscape leading to elevated levels of conjugated ubiquitin, with a higher mono-to-poly ratio. ...Biological assays validated the interference of K0 Ub with protein trafficking and MV …
In vivo expression of lysineless ubiquitin (K0 Ub) perturbed the ubiquitin landscape leading to elevated levels of conjugated …
Studying Protein Ubiquitylation in Yeast.
Hovsepian J, Becuwe M, Kleifeld O, Glickman MH, Léon S. Hovsepian J, et al. Among authors: leon s. Methods Mol Biol. 2016;1449:117-42. doi: 10.1007/978-1-4939-3756-1_5. Methods Mol Biol. 2016. PMID: 27613031
Ubiquitylation is a reversible posttranslational modification that is critical for most, if not all, cellular processes and essential for viability. Ubiquitin conjugates to substrate proteins either as a single moiety (monoubiquitylation) or as polymers composed of ubiq …
Ubiquitylation is a reversible posttranslational modification that is critical for most, if not all, cellular processes and essential for vi …
Ubiquitin ligase adaptors: regulators of ubiquitylation and endocytosis of plasma membrane proteins.
Léon S, Haguenauer-Tsapis R. Léon S, et al. Exp Cell Res. 2009 May 15;315(9):1574-83. doi: 10.1016/j.yexcr.2008.11.014. Epub 2008 Dec 3. Exp Cell Res. 2009. PMID: 19070615 Review.
This ubiquitylation step, which is performed by so-called ubiquitin ligases (or E3), appears therefore as a critical event for endocytosis and is subject to many levels of regulation. In this review, we focus on the regulation of cargo ubiquitylation by accessory proteins, …
This ubiquitylation step, which is performed by so-called ubiquitin ligases (or E3), appears therefore as a critical event for endocy …
Versatile role of the yeast ubiquitin ligase Rsp5p in intracellular trafficking.
Belgareh-Touzé N, Léon S, Erpapazoglou Z, Stawiecka-Mirota M, Urban-Grimal D, Haguenauer-Tsapis R. Belgareh-Touzé N, et al. Among authors: leon s. Biochem Soc Trans. 2008 Oct;36(Pt 5):791-6. doi: 10.1042/BST0360791. Biochem Soc Trans. 2008. PMID: 18793138 Review.
Most Rsp5p substrates do not carry PY motifs, but some may depend on PY-containing proteins for their ubiquitination by Rsp5p, consistent with the latter's acting as specificity factors or adaptors. As in other ubiquitin-conjugating systems, these adaptors ar …
Most Rsp5p substrates do not carry PY motifs, but some may depend on PY-containing proteins for their ubiquitination by Rsp5p, consis …
The α-arrestin family of ubiquitin ligase adaptors links metabolism with selective endocytosis.
Kahlhofer J, Leon S, Teis D, Schmidt O. Kahlhofer J, et al. Among authors: leon s. Biol Cell. 2021 Apr;113(4):183-219. doi: 10.1111/boc.202000137. Epub 2021 Feb 1. Biol Cell. 2021. PMID: 33314196 Review.
In the budding yeast Saccharomyces cerevisiae, 14 different alpha-arrestins (also named arrestin-related trafficking adaptors, ARTs) function as adaptors for the ubiquitin ligase Rsp5. They instruct Rsp5 to ubiquitinate subsets of nutrient transporters to orchestrat …
In the budding yeast Saccharomyces cerevisiae, 14 different alpha-arrestins (also named arrestin-related trafficking adaptors, ARTs) functio …
Ubiquitin-mediated regulation of endocytosis by proteins of the arrestin family.
Becuwe M, Herrador A, Haguenauer-Tsapis R, Vincent O, Léon S. Becuwe M, et al. Among authors: leon s. Biochem Res Int. 2012;2012:242764. doi: 10.1155/2012/242764. Epub 2012 Sep 4. Biochem Res Int. 2012. PMID: 22988512 Free PMC article.
Arrestins also serve as adaptor proteins by promoting the recruitment of ubiquitin ligases and participate in the agonist-induced ubiquitylation of receptors, known to have impact on their subcellular localization and stability. ...In this paper, we discuss recent data on …
Arrestins also serve as adaptor proteins by promoting the recruitment of ubiquitin ligases and participate in the agonist-induced ubi …
Complementary α-arrestin-ubiquitin ligase complexes control nutrient transporter endocytosis in response to amino acids.
Ivashov V, Zimmer J, Schwabl S, Kahlhofer J, Weys S, Gstir R, Jakschitz T, Kremser L, Bonn GK, Lindner H, Huber LA, Leon S, Schmidt O, Teis D. Ivashov V, et al. Among authors: leon s. Elife. 2020 Aug 3;9:e58246. doi: 10.7554/eLife.58246. Elife. 2020. PMID: 32744498 Free PMC article.
How cells adjust nutrient transport across their membranes is incompletely understood. Previously, we have shown that S. cerevisiae broadly re-configures the nutrient transporters at the plasma membrane in response to amino acid availability, through endocytosis of sugar- …
How cells adjust nutrient transport across their membranes is incompletely understood. Previously, we have shown that S. cerevisiae b …
Multilevel regulation of an α-arrestin by glucose depletion controls hexose transporter endocytosis.
Hovsepian J, Defenouillère Q, Albanèse V, Váchová L, Garcia C, Palková Z, Léon S. Hovsepian J, et al. Among authors: leon s. J Cell Biol. 2017 Jun 5;216(6):1811-1831. doi: 10.1083/jcb.201610094. Epub 2017 May 3. J Cell Biol. 2017. PMID: 28468835 Free PMC article.
Nutrient availability controls the landscape of nutrient transporters present at the plasma membrane, notably by regulating their ubiquitylation and subsequent endocytosis. In yeast, this involves the Nedd4 ubiquitin ligase Rsp5 and arrestin-related trafficking adaptors (A …
Nutrient availability controls the landscape of nutrient transporters present at the plasma membrane, notably by regulating their ubiquityla …
Ubc13-Mms2 cooperates with a family of RING E3 proteins in budding yeast membrane protein sorting.
Renz C, Albanèse V, Tröster V, Albert TK, Santt O, Jacobs SC, Khmelinskii A, Léon S, Ulrich HD. Renz C, et al. Among authors: leon s. J Cell Sci. 2020 May 27;133(10):jcs244566. doi: 10.1242/jcs.244566. J Cell Sci. 2020. PMID: 32265276
Polyubiquitin chains linked via lysine (K) 63 play an important role in endocytosis and membrane trafficking. Their primary source is the ubiquitin protein ligase (E3) Rsp5/NEDD4, which acts as a key regulator of membrane protein sorting. The heterodimeric ubiquitin …
Polyubiquitin chains linked via lysine (K) 63 play an important role in endocytosis and membrane trafficking. Their primary source is the …
The yeast arrestin-related protein Bul1 is a novel actor of glucose-induced endocytosis.
Hovsepian J, Albanèse V, Becuwe M, Ivashov V, Teis D, Léon S. Hovsepian J, et al. Among authors: leon s. Mol Biol Cell. 2018 May 1;29(9):1012-1020. doi: 10.1091/mbc.E17-07-0466. Epub 2018 Mar 22. Mol Biol Cell. 2018. PMID: 29514933 Free PMC article.
Transporter endocytosis is triggered by their ubiquitylation, which involves the ubiquitin ligase Rsp5 and its adaptors of the arrestin-related family (ART). ...
Transporter endocytosis is triggered by their ubiquitylation, which involves the ubiquitin ligase Rsp5 and its adaptors of the arrest …
28 results