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Contributions of Myc to tumorigenesis.
Lutz W, Leon J, Eilers M. Lutz W, et al. Biochim Biophys Acta. 2002 Mar 14;1602(1):61-71. doi: 10.1016/s0304-419x(02)00036-7. Biochim Biophys Acta. 2002. PMID: 11960695 Review.
High p27 protein levels in chronic lymphocytic leukemia are associated to low Myc and Skp2 expression, confer resistance to apoptosis and antagonize Myc effects on cell cycle.
Caraballo JM, Acosta JC, Cortés MA, Albajar M, Gómez-Casares MT, Batlle-López A, Cuadrado MA, Onaindia A, Bretones G, Llorca J, Piris MA, Colomer D, León J. Caraballo JM, et al. Oncotarget. 2014 Jul 15;5(13):4694-708. doi: 10.18632/oncotarget.2100. Oncotarget. 2014. PMID: 25051361 Free PMC article.
Myc and cell cycle control.
Bretones G, Delgado MD, León J. Bretones G, et al. Biochim Biophys Acta. 2015 May;1849(5):506-16. doi: 10.1016/j.bbagrm.2014.03.013. Epub 2014 Apr 1. Biochim Biophys Acta. 2015. PMID: 24704206 Review.
MYC oncogene in myeloid neoplasias.
Delgado MD, Albajar M, Gomez-Casares MT, Batlle A, León J. Delgado MD, et al. Clin Transl Oncol. 2013 Feb;15(2):87-94. doi: 10.1007/s12094-012-0926-8. Epub 2012 Aug 22. Clin Transl Oncol. 2013. PMID: 22911553 Review.
Myc antagonizes Ras-mediated growth arrest in leukemia cells through the inhibition of the Ras-ERK-p21Cip1 pathway.
Vaqué JP, Navascues J, Shiio Y, Laiho M, Ajenjo N, Mauleon I, Matallanas D, Crespo P, León J. Vaqué JP, et al. J Biol Chem. 2005 Jan 14;280(2):1112-22. doi: 10.1074/jbc.M409503200. Epub 2004 Nov 4. J Biol Chem. 2005. PMID: 15528212
Kinetics of myc-max-mad gene expression during hepatocyte proliferation in vivo: Differential regulation of mad family and stress-mediated induction of c-myc.
Mauleon I, Lombard MN, Muñoz-Alonso MJ, Cañelles M, Leon J. Mauleon I, et al. Mol Carcinog. 2004 Feb;39(2):85-90. doi: 10.1002/mc.20000. Mol Carcinog. 2004. PMID: 14750213
Myc represses differentiation-induced p21CIP1 expression via Miz-1-dependent interaction with the p21 core promoter.
Wu S, Cetinkaya C, Munoz-Alonso MJ, von der Lehr N, Bahram F, Beuger V, Eilers M, Leon J, Larsson LG. Wu S, et al. Oncogene. 2003 Jan 23;22(3):351-60. doi: 10.1038/sj.onc.1206145. Oncogene. 2003. PMID: 12545156
Sin3b interacts with Myc and decreases Myc levels.
Garcia-Sanz P, Quintanilla A, Lafita MC, Moreno-Bueno G, García-Gutierrez L, Tabor V, Varela I, Shiio Y, Larsson LG, Portillo F, Leon J. Garcia-Sanz P, et al. J Biol Chem. 2014 Aug 8;289(32):22221-36. doi: 10.1074/jbc.M113.538744. Epub 2014 Jun 20. J Biol Chem. 2014. PMID: 24951594 Free PMC article.
Myc inhibits p27-induced erythroid differentiation of leukemia cells by repressing erythroid master genes without reversing p27-mediated cell cycle arrest.
Acosta JC, Ferrándiz N, Bretones G, Torrano V, Blanco R, Richard C, O'Connell B, Sedivy J, Delgado MD, León J. Acosta JC, et al. Mol Cell Biol. 2008 Dec;28(24):7286-95. doi: 10.1128/MCB.00752-08. Epub 2008 Oct 6. Mol Cell Biol. 2008. PMID: 18838534 Free PMC article.
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