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Jaks and STATs: biological implications.
Leonard WJ, O'Shea JJ. Leonard WJ, et al. Annu Rev Immunol. 1998;16:293-322. doi: 10.1146/annurev.immunol.16.1.293. Annu Rev Immunol. 1998. PMID: 9597132 Review.
The common cytokine receptor gamma chain plays an essential role in regulating lymphoid homeostasis.
Nakajima H, Shores EW, Noguchi M, Leonard WJ. Nakajima H, et al. Among authors: leonard wj. J Exp Med. 1997 Jan 20;185(2):189-95. doi: 10.1084/jem.185.2.189. J Exp Med. 1997. PMID: 9016868 Free PMC article.
IL-2 negatively regulates IL-7 receptor alpha chain expression in activated T lymphocytes.
Xue HH, Kovanen PE, Pise-Masison CA, Berg M, Radovich MF, Brady JN, Leonard WJ. Xue HH, et al. Among authors: leonard wj. Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13759-64. doi: 10.1073/pnas.212214999. Epub 2002 Sep 27. Proc Natl Acad Sci U S A. 2002. PMID: 12354940 Free PMC article.
A TSLP-complement axis mediates neutrophil killing of methicillin-resistant Staphylococcus aureus.
West EE, Spolski R, Kazemian M, Yu ZX, Kemper C, Leonard WJ. West EE, et al. Among authors: leonard wj. Sci Immunol. 2016 Nov 18;1(5):eaaf8471. doi: 10.1126/sciimmunol.aaf8471. Sci Immunol. 2016. PMID: 28783679
Cutting Edge: Expression of IRF8 in Gastric Epithelial Cells Confers Protective Innate Immunity against Helicobacter pylori Infection.
Yan M, Wang H, Sun J, Liao W, Li P, Zhu Y, Xu C, Joo J, Sun Y, Abbasi S, Kovalchuk A, Lv N, Leonard WJ, Morse HC 3rd. Yan M, et al. Among authors: leonard wj. J Immunol. 2016 Mar 1;196(5):1999-2003. doi: 10.4049/jimmunol.1500766. Epub 2016 Feb 3. J Immunol. 2016. PMID: 26843324 Free PMC article.
A molecular threshold for effector CD8(+) T cell differentiation controlled by transcription factors Blimp-1 and T-bet.
Xin A, Masson F, Liao Y, Preston S, Guan T, Gloury R, Olshansky M, Lin JX, Li P, Speed TP, Smyth GK, Ernst M, Leonard WJ, Pellegrini M, Kaech SM, Nutt SL, Shi W, Belz GT, Kallies A. Xin A, et al. Among authors: leonard wj. Nat Immunol. 2016 Apr;17(4):422-32. doi: 10.1038/ni.3410. Epub 2016 Mar 7. Nat Immunol. 2016. PMID: 26950239 Free PMC article.
Interleukin-2 activity can be fine tuned with engineered receptor signaling clamps.
Mitra S, Ring AM, Amarnath S, Spangler JB, Li P, Ju W, Fischer S, Oh J, Spolski R, Weiskopf K, Kohrt H, Foley JE, Rajagopalan S, Long EO, Fowler DH, Waldmann TA, Garcia KC, Leonard WJ. Mitra S, et al. Among authors: leonard wj. Immunity. 2015 May 19;42(5):826-38. doi: 10.1016/j.immuni.2015.04.018. Immunity. 2015. PMID: 25992859 Free PMC article.
Interleukin-21: a double-edged sword with therapeutic potential.
Spolski R, Leonard WJ. Spolski R, et al. Among authors: leonard wj. Nat Rev Drug Discov. 2014 May;13(5):379-95. doi: 10.1038/nrd4296. Epub 2014 Apr 22. Nat Rev Drug Discov. 2014. PMID: 24751819 Review.
Chromatin Accessibility and Interactions in the Transcriptional Regulation of T Cells.
Li P, Leonard WJ. Li P, et al. Among authors: leonard wj. Front Immunol. 2018 Nov 22;9:2738. doi: 10.3389/fimmu.2018.02738. eCollection 2018. Front Immunol. 2018. PMID: 30524449 Free PMC article. Review.
Priming for T helper type 2 differentiation by interleukin 2-mediated induction of interleukin 4 receptor alpha-chain expression.
Liao W, Schones DE, Oh J, Cui Y, Cui K, Roh TY, Zhao K, Leonard WJ. Liao W, et al. Among authors: leonard wj. Nat Immunol. 2008 Nov;9(11):1288-96. doi: 10.1038/ni.1656. Epub 2008 Sep 28. Nat Immunol. 2008. PMID: 18820682 Free PMC article.
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