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Bone marrow cells regenerate infarcted myocardium.
Orlic D, Kajstura J, Chimenti S, Jakoniuk I, Anderson SM, Li B, Pickel J, McKay R, Nadal-Ginard B, Bodine DM, Leri A, Anversa P. Orlic D, et al. Among authors: leri a. Nature. 2001 Apr 5;410(6829):701-5. doi: 10.1038/35070587. Nature. 2001. PMID: 11287958
Injury to a target organ is sensed by distant stem cells, which migrate to the site of damage and undergo alternate stem cell differentiation; these events promote structural and functional repair. ...
Injury to a target organ is sensed by distant stem cells, which migrate to the site of damage and undergo alternate stem cell differe …
Mobilized bone marrow cells repair the infarcted heart, improving function and survival.
Orlic D, Kajstura J, Chimenti S, Limana F, Jakoniuk I, Quaini F, Nadal-Ginard B, Bodine DM, Leri A, Anversa P. Orlic D, et al. Among authors: leri a. Proc Natl Acad Sci U S A. 2001 Aug 28;98(18):10344-9. doi: 10.1073/pnas.181177898. Epub 2001 Aug 14. Proc Natl Acad Sci U S A. 2001. PMID: 11504914 Free PMC article.
Two critical determinants seem to be required for the transdifferentiation of primitive BMC: tissue damage and a high level of pluripotent cells. ...In conclusion, mobilization of primitive BMC by cytokines might offer a noninvasive therapeutic strategy for the rege …
Two critical determinants seem to be required for the transdifferentiation of primitive BMC: tissue damage and a high level of plurip …
Pim-1 regulates cardiomyocyte survival downstream of Akt.
Muraski JA, Rota M, Misao Y, Fransioli J, Cottage C, Gude N, Esposito G, Delucchi F, Arcarese M, Alvarez R, Siddiqi S, Emmanuel GN, Wu W, Fischer K, Martindale JJ, Glembotski CC, Leri A, Kajstura J, Magnuson N, Berns A, Beretta RM, Houser SR, Schaefer EM, Anversa P, Sussman MA. Muraski JA, et al. Among authors: leri a. Nat Med. 2007 Dec;13(12):1467-75. doi: 10.1038/nm1671. Epub 2007 Nov 25. Nat Med. 2007. PMID: 18037896
Although Akt is known to be a crucial signaling protein in the myocardium, the role of Pim-1 has been overlooked. Pim-1 expression in the myocardium of mice decreased during postnatal development, re-emerged after acute pathological injury in mice and was increased in fail …
Although Akt is known to be a crucial signaling protein in the myocardium, the role of Pim-1 has been overlooked. Pim-1 expression in …
Local activation or implantation of cardiac progenitor cells rescues scarred infarcted myocardium improving cardiac function.
Rota M, Padin-Iruegas ME, Misao Y, De Angelis A, Maestroni S, Ferreira-Martins J, Fiumana E, Rastaldo R, Arcarese ML, Mitchell TS, Boni A, Bolli R, Urbanek K, Hosoda T, Anversa P, Leri A, Kajstura J. Rota M, et al. Among authors: leri a. Circ Res. 2008 Jul 3;103(1):107-16. doi: 10.1161/CIRCRESAHA.108.178525. Epub 2008 Jun 12. Circ Res. 2008. PMID: 18556576 Free PMC article.
Ischemic heart disease is characterized chronically by a healed infarct, foci of myocardial scarring, cavitary dilation, and impaired ventricular performance. ...Hepatocyte growth factor is a powerful chemoattractant of CPCs, and insulin-like growth factor-1 promote …
Ischemic heart disease is characterized chronically by a healed infarct, foci of myocardial scarring, cavitary dilation, and impaired …
Cardiac stem cells possess growth factor-receptor systems that after activation regenerate the infarcted myocardium, improving ventricular function and long-term survival.
Urbanek K, Rota M, Cascapera S, Bearzi C, Nascimbene A, De Angelis A, Hosoda T, Chimenti S, Baker M, Limana F, Nurzynska D, Torella D, Rotatori F, Rastaldo R, Musso E, Quaini F, Leri A, Kajstura J, Anversa P. Urbanek K, et al. Among authors: leri a. Circ Res. 2005 Sep 30;97(7):663-73. doi: 10.1161/01.RES.0000183733.53101.11. Epub 2005 Sep 1. Circ Res. 2005. PMID: 16141414
To facilitate migration and homing of CSCs-ECCs to the infarct, a growth factor gradient was introduced between the site of storage of primitive cells in the atria and the region bordering the infarct. ...
To facilitate migration and homing of CSCs-ECCs to the infarct, a growth factor gradient was introduced between the site of storage o …
Intracoronary administration of cardiac progenitor cells alleviates left ventricular dysfunction in rats with a 30-day-old infarction.
Tang XL, Rokosh G, Sanganalmath SK, Yuan F, Sato H, Mu J, Dai S, Li C, Chen N, Peng Y, Dawn B, Hunt G, Leri A, Kajstura J, Tiwari S, Shirk G, Anversa P, Bolli R. Tang XL, et al. Among authors: leri a. Circulation. 2010 Jan 19;121(2):293-305. doi: 10.1161/CIRCULATIONAHA.109.871905. Epub 2010 Jan 4. Circulation. 2010. PMID: 20048209 Free PMC article.
Cardiac stem cells delivered intravascularly traverse the vessel barrier, regenerate infarcted myocardium, and improve cardiac function.
Dawn B, Stein AB, Urbanek K, Rota M, Whang B, Rastaldo R, Torella D, Tang XL, Rezazadeh A, Kajstura J, Leri A, Hunt G, Varma J, Prabhu SD, Anversa P, Bolli R. Dawn B, et al. Among authors: leri a. Proc Natl Acad Sci U S A. 2005 Mar 8;102(10):3766-71. doi: 10.1073/pnas.0405957102. Epub 2005 Feb 25. Proc Natl Acad Sci U S A. 2005. PMID: 15734798 Free PMC article.
Thus, rats were subjected to a 90-min coronary occlusion; at 4 h after reperfusion, CSCs were delivered to the coronary arteries via a catheter positioned into the aortic root. ...Pathologic analysis showed that treated hearts exhibited a smaller increase in …
Thus, rats were subjected to a 90-min coronary occlusion; at 4 h after reperfusion, CSCs were delivered to the coronary arteries via …
Regeneration of the infarcted heart with stem cells derived by nuclear transplantation.
Lanza R, Moore MA, Wakayama T, Perry AC, Shieh JH, Hendrikx J, Leri A, Chimenti S, Monsen A, Nurzynska D, West MD, Kajstura J, Anversa P. Lanza R, et al. Among authors: leri a. Circ Res. 2004 Apr 2;94(6):820-7. doi: 10.1161/01.RES.0000120863.53562.DF. Epub 2004 Feb 5. Circ Res. 2004. PMID: 14764454
Nuclear transfer techniques have been proposed as a strategy for generating an unlimited supply of rejuvenated and histocompatible stem cells for the treatment of cardiac diseases. ...Cloned embryos were derived from somatic cell fusion between nuclei of cultured LacZ-posi …
Nuclear transfer techniques have been proposed as a strategy for generating an unlimited supply of rejuvenated and histocompatible st …
Bone marrow stem cells regenerate infarcted myocardium.
Orlic D, Kajstura J, Chimenti S, Bodine DM, Leri A, Anversa P. Orlic D, et al. Among authors: leri a. Pediatr Transplant. 2003;7 Suppl 3:86-8. doi: 10.1034/j.1399-3046.7.s3.13.x. Pediatr Transplant. 2003. PMID: 12603699 Review.
Stem cells: bone-marrow-derived cells and heart failure--the debate goes on.
Leri A, Anversa P. Leri A, et al. Nat Rev Cardiol. 2013 Jul;10(7):372-3. doi: 10.1038/nrcardio.2013.81. Epub 2013 May 28. Nat Rev Cardiol. 2013. PMID: 23712104 Free PMC article.
The therapeutic efficacy of bone-marrow-derived cells in patients with acute or chronic myocardial infarction has been a matter of intense debate. ...
The therapeutic efficacy of bone-marrow-derived cells in patients with acute or chronic myocardial infarction has been a matter of in …
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