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Rationale for enteroviral vaccination and antiviral therapies in human type 1 diabetes.
Dunne JL, Richardson SJ, Atkinson MA, Craig ME, Dahl-Jørgensen K, Flodström-Tullberg M, Hyöty H, Insel RA, Lernmark Å, Lloyd RE, Morgan NG, Pugliese A. Dunne JL, et al. Diabetologia. 2019 May;62(5):744-753. doi: 10.1007/s00125-019-4811-7. Epub 2019 Jan 23. Diabetologia. 2019. PMID: 30675626 Free PMC article. Review.
The disease develops in genetically susceptible individuals, but a role for environmental factors has been postulated. Viral infections have long been considered as candidates for environmental triggers but, given the lack of evidence for an acute, widespread, cytopathic e …
The disease develops in genetically susceptible individuals, but a role for environmental factors has been postulated. Viral infectio …
Predictive value of islet cell and insulin autoantibodies for type 1 (insulin-dependent) diabetes mellitus in a population-based study of newly-diagnosed diabetic and matched control children.
Landin-Olsson M, Palmer JP, Lernmark A, Blom L, Sundkvist G, Nyström L, Dahlquist G. Landin-Olsson M, et al. Diabetologia. 1992 Nov;35(11):1068-73. doi: 10.1007/BF02221683. Diabetologia. 1992. PMID: 1473617
The predictive value of finding a patient with the disease was only 7% since 4% of the control children were antibody-positive and the cumulative incidence rate up to 15 years of age is 0.38%. ...
The predictive value of finding a patient with the disease was only 7% since 4% of the control children were antibody-positive and th …
Islet cell antibodies and fasting C-peptide predict insulin requirement at diagnosis of diabetes mellitus.
Landin-Olsson M, Nilsson KO, Lernmark A, Sundkvist G. Landin-Olsson M, et al. Diabetologia. 1990 Sep;33(9):561-8. doi: 10.1007/BF00404145. Diabetologia. 1990. PMID: 2253834
Age, body mass index, HbA1c, C-peptide, and levels of islet cell antibodies were determined at the clinical onset, and related to the classification at diagnosis and at follow-up (n = 233) after a median time of 31 (range 1-49) months. ...
Age, body mass index, HbA1c, C-peptide, and levels of islet cell antibodies were determined at the clinical onset, and related to the classi …
Islet cell and other organ-specific autoantibodies in all children developing type 1 (insulin-dependent) diabetes mellitus in Sweden during one year and in matched control children.
Landin-Olsson M, Karlsson A, Dahlquist G, Blom L, Lernmark A, Sundkvist G. Landin-Olsson M, et al. Diabetologia. 1989 Jun;32(6):387-95. doi: 10.1007/BF00277264. Diabetologia. 1989. PMID: 2547682
The majority (about 90%) of children developing Type 1 (insulin-dependent) diabetes mellitus do not have a first-degree relative with the disease. ...
The majority (about 90%) of children developing Type 1 (insulin-dependent) diabetes mellitus do not have a first-degree relative with …
Factors influencing the magnitude, duration, and rate of fall of B-cell function in type 1 (insulin-dependent) diabetic children followed for two years from their clinical diagnosis.
Wallensteen M, Dahlquist G, Persson B, Landin-Olsson M, Lernmark A, Sundkvist G, Thalme B. Wallensteen M, et al. Diabetologia. 1988 Sep;31(9):664-9. doi: 10.1007/BF00278749. Diabetologia. 1988. PMID: 3069534
Maximum values of fasting and postprandial plasma C-peptide were reached at a median duration of three months. Thereafter both plasma and urinary C-peptide declined linearly. ...
Maximum values of fasting and postprandial plasma C-peptide were reached at a median duration of three months. Thereafter both plasma …
Pathogenesis of insulin-dependent diabetes mellitus.
Falorni A, Kockum I, Sanjeevi CB, Lernmark A. Falorni A, et al. Baillieres Clin Endocrinol Metab. 1995 Jan;9(1):25-46. doi: 10.1016/s0950-351x(95)80803-5. Baillieres Clin Endocrinol Metab. 1995. PMID: 7726797 Review.
The pathogenesis is a specific loss of pancreatic beta cells. The dissection of IDDM genes is complicated by the low recurrence rate of the disease among first-degree relatives. ...Autoantibodies to numerous other beta cell autoantigens are detected at the clinical onset b …
The pathogenesis is a specific loss of pancreatic beta cells. The dissection of IDDM genes is complicated by the low recurrence rate …
Molecular biology of IDDM.
Lernmark A. Lernmark A. Diabetologia. 1994 Sep;37 Suppl 2:S73-81. doi: 10.1007/BF00400829. Diabetologia. 1994. PMID: 7821743
HLA and glutamic acid decarboxylase in human insulin-dependent diabetes mellitus.
Sanjeevi CB, Falorni A, Kockum I, Hagopian WA, Lernmark A. Sanjeevi CB, et al. Diabet Med. 1996 Mar;13(3):209-17. doi: 10.1002/(SICI)1096-9136(199603)13:3<209::AID-DIA39>3.0.CO;2-2. Diabet Med. 1996. PMID: 8689840 Review.
At the same time, the molecular cloning of human islet GAD65 and the development of precise and reproducible GAD65Ab assays with recombinant human GAD65 has given new insights to the problem of to what extent HLA control the development of a GAD65 immune response or to the …
At the same time, the molecular cloning of human islet GAD65 and the development of precise and reproducible GAD65Ab assays with recombinant …
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