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Immunology of beta-cell destruction.
La Torre D, Lernmark A. La Torre D, et al. Adv Exp Med Biol. 2010;654:537-83. doi: 10.1007/978-90-481-3271-3_24. Adv Exp Med Biol. 2010. PMID: 20217514 Review.
The different steps that eventually lead to the complete loss of the beta-cells are reviewed to include the very first step of a triggering event that initiates the development of beta-cell autoimmunity to the last step of appearance of islet-cell autoantibodies, which may …
The different steps that eventually lead to the complete loss of the beta-cells are reviewed to include the very first step of a trig …
Detection and possible functional influence of antibodies directed againt the pancreatic islet cell surface.
Lernmark A, Kanatsuna T, Rubenstein AH, Steiner DF. Lernmark A, et al. Adv Exp Med Biol. 1979;119:157-63. doi: 10.1007/978-1-4615-9110-8_23. Adv Exp Med Biol. 1979. PMID: 91312
Antibodies directed towards determinants on the surface of rat islet cells can be detected qualitatively by the indirect immunofluorescence or quantitatively by a specific radioassay for IgG. ...
Antibodies directed towards determinants on the surface of rat islet cells can be detected qualitatively by the indirect immunofluorescence …
Pancreatic beta-cell function evaluated by intravenous glucose and glucagon stimulation. A comparison between insulin and C-peptide to measure insulin secretion.
Gottsäter A, Landin-Olsson M, Fernlund P, Gullberg B, Lernmark A, Sundkvist G. Gottsäter A, et al. Scand J Clin Lab Invest. 1992 Nov;52(7):631-9. doi: 10.3109/00365519209115506. Scand J Clin Lab Invest. 1992. PMID: 1455155
Predictive value of islet cell and insulin autoantibodies for type 1 (insulin-dependent) diabetes mellitus in a population-based study of newly-diagnosed diabetic and matched control children.
Landin-Olsson M, Palmer JP, Lernmark A, Blom L, Sundkvist G, Nyström L, Dahlquist G. Landin-Olsson M, et al. Diabetologia. 1992 Nov;35(11):1068-73. doi: 10.1007/BF02221683. Diabetologia. 1992. PMID: 1473617
The predictive value of finding a patient with the disease was only 7% since 4% of the control children were antibody-positive and the cumulative incidence rate up to 15 years of age is 0.38%. ...
The predictive value of finding a patient with the disease was only 7% since 4% of the control children were antibody-positive and th …
Islet cell antibody reactivity with human fetal pancreatic islets.
Sundkvist G, Bergqvist A, Weibull H, Bergqvist D, Fält K, Olsson ML, Lernmark A. Sundkvist G, et al. Diabetes Res Clin Pract. 1991 Oct;14(1):1-7. doi: 10.1016/0168-8227(91)90046-g. Diabetes Res Clin Pract. 1991. PMID: 1748059
Pancreatic islets positive for a monoclonal proinsulin antibody but non-reactive with ICA negative control serum were found in 9/14 pancreata and all (9/9) of them showed a positive reaction with the ICA standard. ...
Pancreatic islets positive for a monoclonal proinsulin antibody but non-reactive with ICA negative control serum were found in 9/14 p …
Islet cell antibodies and fasting C-peptide predict insulin requirement at diagnosis of diabetes mellitus.
Landin-Olsson M, Nilsson KO, Lernmark A, Sundkvist G. Landin-Olsson M, et al. Diabetologia. 1990 Sep;33(9):561-8. doi: 10.1007/BF00404145. Diabetologia. 1990. PMID: 2253834
Age, body mass index, HbA1c, C-peptide, and levels of islet cell antibodies were determined at the clinical onset, and related to the classification at diagnosis and at follow-up (n = 233) after a median time of 31 (range 1-49) months. ...
Age, body mass index, HbA1c, C-peptide, and levels of islet cell antibodies were determined at the clinical onset, and related to the classi …
Islet cell and other organ-specific autoantibodies in all children developing type 1 (insulin-dependent) diabetes mellitus in Sweden during one year and in matched control children.
Landin-Olsson M, Karlsson A, Dahlquist G, Blom L, Lernmark A, Sundkvist G. Landin-Olsson M, et al. Diabetologia. 1989 Jun;32(6):387-95. doi: 10.1007/BF00277264. Diabetologia. 1989. PMID: 2547682
The majority (about 90%) of children developing Type 1 (insulin-dependent) diabetes mellitus do not have a first-degree relative with the disease. ...
The majority (about 90%) of children developing Type 1 (insulin-dependent) diabetes mellitus do not have a first-degree relative with …
Pancreatic antibodies as a marker for pancreatic graft rejection.
Landin-Olsson M, Sundkvist G, Lernmark A, Weibull H, Takolander R, Bergqvist D, Fält K, Gäbel H. Landin-Olsson M, et al. Transplant Proc. 1987 Oct;19(5):3890-1. Transplant Proc. 1987. PMID: 3313956 No abstract available.
Immunological aspects of type 1 and 2 diabetes mellitus.
Lernmark A, Baekkeskov S, Gerling I, Kastern W, Knutson C, Michelsen B. Lernmark A, et al. Adv Exp Med Biol. 1985;189:107-27. doi: 10.1007/978-1-4757-1850-8_7. Adv Exp Med Biol. 1985. PMID: 4036712
The presence of a number of immune abnormalities argues that the causes of IDDM may be sought in an altered immune reaction against antigens present in the pancreatic B cells and/or in the environment. ...Multiple exposures to this or related antigens throughout several ye …
The presence of a number of immune abnormalities argues that the causes of IDDM may be sought in an altered immune reaction against a …
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