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Immune therapy in type 1 diabetes mellitus.
Lernmark A, Larsson HE. Lernmark A, et al. Nat Rev Endocrinol. 2013 Feb;9(2):92-103. doi: 10.1038/nrendo.2012.237. Epub 2013 Jan 8. Nat Rev Endocrinol. 2013. PMID: 23296174 Review.
In most countries, only 10-15% of children or young adults newly diagnosed with T1DM have a first-degree relative with the disease. ...
In most countries, only 10-15% of children or young adults newly diagnosed with T1DM have a first-degree relative with the disease. . …
Islet-cell-surface antibodies in juvenile diabetes mellitus.
Lernmark A, Freedman ZR, Hofmann C, Rubenstein AH, Steiner DF, Jackson RL, Winter RJ, Traisman HS. Lernmark A, et al. N Engl J Med. 1978 Aug 24;299(8):375-80. doi: 10.1056/NEJM197808242990802. N Engl J Med. 1978. PMID: 353557
Genetic dissection of autoimmune type I diabetes in the BB rat.
Jacob HJ, Pettersson A, Wilson D, Mao Y, Lernmark A, Lander ES. Jacob HJ, et al. Among authors: lernmark a. Nat Genet. 1992 Sep;2(1):56-60. doi: 10.1038/ng0992-56. Nat Genet. 1992. PMID: 1303251
One unusual feature is a severe T-cell lymphopenia, which appears to be inherited as a recessive trait controlled by a single gene, Lyp. Based on genetic analysis of several crosses, we show that development of diabetes involves at least three genes: Lyp, whi …
One unusual feature is a severe T-cell lymphopenia, which appears to be inherited as a recessive trait controlled by a
Predictive value of islet cell and insulin autoantibodies for type 1 (insulin-dependent) diabetes mellitus in a population-based study of newly-diagnosed diabetic and matched control children.
Landin-Olsson M, Palmer JP, Lernmark A, Blom L, Sundkvist G, Nyström L, Dahlquist G. Landin-Olsson M, et al. Among authors: lernmark a. Diabetologia. 1992 Nov;35(11):1068-73. doi: 10.1007/BF02221683. Diabetologia. 1992. PMID: 1473617
The predictive value of finding a patient with the disease was only 7% since 4% of the control children were antibody-positive and the cumulative incidence rate up to 15 years of age is 0.38%. ...
The predictive value of finding a patient with the disease was only 7% since 4% of the control children were antibody-positive and th …
Islet cell and thyrogastric antibodies in 633 consecutive 15- to 34-yr-old patients in the diabetes incidence study in Sweden.
Landin-Olsson M, Karlsson FA, Lernmark A, Sundkvist G. Landin-Olsson M, et al. Among authors: lernmark a. Diabetes. 1992 Aug;41(8):1022-7. doi: 10.2337/diab.41.8.1022. Diabetes. 1992. PMID: 1628762
Islet cell antibody reactivity with human fetal pancreatic islets.
Sundkvist G, Bergqvist A, Weibull H, Bergqvist D, Fält K, Olsson ML, Lernmark A. Sundkvist G, et al. Among authors: lernmark a. Diabetes Res Clin Pract. 1991 Oct;14(1):1-7. doi: 10.1016/0168-8227(91)90046-g. Diabetes Res Clin Pract. 1991. PMID: 1748059
Pancreatic islets positive for a monoclonal proinsulin antibody but non-reactive with ICA negative control serum were found in 9/14 pancreata and all (9/9) of them showed a positive reaction with the ICA standard. ...
Pancreatic islets positive for a monoclonal proinsulin antibody but non-reactive with ICA negative control serum were found in 9/14 p …
Autoimmunity of diabetes.
Lernmark A, Bärmeier H, Dube S, Hagopian W, Karlsen A, Wassmuth R. Lernmark A, et al. Endocrinol Metab Clin North Am. 1991 Sep;20(3):589-617. Endocrinol Metab Clin North Am. 1991. PMID: 1935920 Review.
Insulin-dependent diabetes mellitus is associated with a growing number of immune abnormalities. At the time of clinical onset, most patients developing the disease as children or young adults have autoantibodies reactive with islet beta cells. ...Studies in first-degree r …
Insulin-dependent diabetes mellitus is associated with a growing number of immune abnormalities. At the time of clinical onset, most …
Risk for developing type 1 (insulin-dependent) diabetes mellitus and the presence of islet 64K antibodies.
Bärmeier H, McCulloch DK, Neifing JL, Warnock G, Rajotte RV, Palmer JP, Lernmark A. Bärmeier H, et al. Among authors: lernmark a. Diabetologia. 1991 Oct;34(10):727-33. doi: 10.1007/BF00401518. Diabetologia. 1991. PMID: 1959705
Antibodies against a Mr 64,000 (64K) islet Beta-cell protein, identified as glutamic acid decarboxylase, have been reported both at and several years prior to the clinical onset of Type 1 diabetes. ...
Antibodies against a Mr 64,000 (64K) islet Beta-cell protein, identified as glutamic acid decarboxylase, have been reported both at a …
Immunoreactive trypsin(ogen) in the sera of children with recent-onset insulin-dependent diabetes and matched controls. The Swedish Childhood Diabetes Group.
Landin-Olsson M, Borgström A, Blom L, Sundkvist G, Lernmark A. Landin-Olsson M, et al. Among authors: lernmark a. Pancreas. 1990 May;5(3):241-7. doi: 10.1097/00006676-199005000-00001. Pancreas. 1990. PMID: 2188253
The median level of anodal trypsin(ogen) was 5 (quartile range, 3-7) micrograms/L in children with newly diagnosed diabetes, compared with a median level of 7 (quartile range, 4-8) micrograms/L in control subjects (p less than 0.0001). Similarly, the median level of cathod …
The median level of anodal trypsin(ogen) was 5 (quartile range, 3-7) micrograms/L in children with newly diagnosed diabetes, compared with …
A novel microwell indirect immunofluorescence assay to detect antibodies against islet cell surface antigens in insulin-dependent diabetes mellitus.
Matsuba I, Lernmark A. Matsuba I, et al. Among authors: lernmark a. Reg Immunol. 1990 Jan-Feb;3(1):23-8. Reg Immunol. 1990. PMID: 2223554
The prevalence of ICSA of a titer equal to or greater than 1:4 was 33% (p less than 0.001) in IDDM patients and 15% (p less than 0.01) in siblings, compared to 5% among the controls. ...The ICSA titer at the time of diagnosis varied between 1:4 and 1:32; however, 43% (23/5 …
The prevalence of ICSA of a titer equal to or greater than 1:4 was 33% (p less than 0.001) in IDDM patients and 15% (p less than 0.01 …
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