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2023 1
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Page 1
Difficult-to-treat inflammatory bowel disease: Effectiveness and safety of 4th and 5th lines of treatment.
Caron B, Habert A, Bonsack O, Camara H, Jeanbert E, Parigi TL, Netter P, Danese S, Peyrin-Biroulet L. Caron B, et al. United European Gastroenterol J. 2024 Jun;12(5):605-613. doi: 10.1002/ueg2.12547. Epub 2024 Apr 9. United European Gastroenterol J. 2024. PMID: 38594841 Free PMC article.
AIM: The objective of this study was to investigate for the first time the treatment persistence, efficacy and safety of biologics or small molecules used in 4th or 5th line therapy. METHODS: We reviewed all consecutive patients with IBD treated at the Nancy University Hos …
AIM: The objective of this study was to investigate for the first time the treatment persistence, efficacy and safety of biologics or small …
Potential Alternative Receptors for SARS-CoV-2-Induced Kidney Damage: TLR-4, KIM-1/TIM-1, and CD147.
Habeichi NJ, Amin G, Lakkis B, Kataya R, Mericskay M, Booz GW, Zouein FA. Habeichi NJ, et al. Front Biosci (Landmark Ed). 2024 Jan 12;29(1):8. doi: 10.31083/j.fbl2901008. Front Biosci (Landmark Ed). 2024. PMID: 38287815 Free PMC article. Review.
This review presents the potential involvement of toll-like receptor 4 (TLR-4), kidney injury molecule-1/T cell immunoglobulin mucin domain 1 (KIM-1/TIM-1), and cluster of differentiation 147 (CD147) in SARS-CoV-2-associated renal damage. ...
This review presents the potential involvement of toll-like receptor 4 (TLR-4), kidney injury molecule-1/T cell immunoglobulin mucin …
Discovery of indoleninyl-pyrazolo[3,4-b]pyridines as potent chemotherapeutic agents against colorectal cancer cells.
Basir NH, Ramle AQ, Ng MP, Tan CH, Tiekink ERT, Sim KS, Basirun WJ, Khairuddean M. Basir NH, et al. Bioorg Chem. 2024 May;146:107256. doi: 10.1016/j.bioorg.2024.107256. Epub 2024 Mar 2. Bioorg Chem. 2024. PMID: 38460334
X-ray crystallography on a representative derivative, 5n, revealed two close to planar conformations whereby the N-atom of the pyridyl residue was syn or anti to the pyrrole-N atom in the two independent molecules of the asymmetric unit. The computational and DNA binding d …
X-ray crystallography on a representative derivative, 5n, revealed two close to planar conformations whereby the N-atom of the pyridyl resid …
How is Membrane Permeation of Small Ionizable Molecules Affected by Protonation Kinetics?
Harris J, Chipot C, Roux B. Harris J, et al. J Phys Chem B. 2024 Jan 25;128(3):795-811. doi: 10.1021/acs.jpcb.3c06765. Epub 2024 Jan 16. J Phys Chem B. 2024. PMID: 38227958 Free PMC article.
With biased WTM-eABF molecular dynamics simulations, we computed the potential of mean force and diffusivity of each ionization state of two weakly basic small molecules: nicotine, an addictive drug, and varenicline, a therapeutic for treating nicotine addiction. ...Essent …
With biased WTM-eABF molecular dynamics simulations, we computed the potential of mean force and diffusivity of each ionization state of two …
Severe adult hemophagocytic lymphohistiocytosis (HLHa) correlates with HLH-related gene variants.
Bloch C, Jais JP, Gil M, Boubaya M, Lepelletier Y, Bader-Meunier B, Mahlaoui N, Garcelon N, Lambotte O, Launay D, Larroche C, Lazaro E, Liffermann F, Lortholary O, Michel M, Michot JM, Morel P, Cheminant M, Suarez F, Terriou L, Urbanski G, Viallard JF, Alcais A, Fischer A, de Saint Basile G, Hermine O; French HLH Study Group. Bloch C, et al. J Allergy Clin Immunol. 2024 Jan;153(1):256-264. doi: 10.1016/j.jaci.2023.07.023. Epub 2023 Sep 9. J Allergy Clin Immunol. 2024. PMID: 37678575 Free article.
In a logistic regression model, only the number of variants was significantly associated with HLHa severity (1 vs 0: 3.86 [1.73-9.14], P = .0008; 2-3 vs 0: 29.4 [3.62-3810], P = .0002) and refractoriness (1 vs 0: 2.47 [1.17-5.34], P = .018; 2-3 vs 0: 13.2 [2.91-126.8], P = …
In a logistic regression model, only the number of variants was significantly associated with HLHa severity (1 vs 0: 3.86 [1.73-9.14], P = . …
Synthesis of N-(3-Acyloxyacyl)glycines, Small Molecules with Potential Role in Gut Microbiome-Endocannabinoidome Communication.
Villano R, Di Marzo V. Villano R, et al. Molecules. 2024 Aug 5;29(15):3703. doi: 10.3390/molecules29153703. Molecules. 2024. PMID: 39125106 Free PMC article.
The key point of the synthetic strategy was the use of commendamide t-butyl ester as a synthetic intermediate, a choice that allowed the removal of the protecting group at the end of the synthetic procedure without degrading of the other ester bond present in the molecule. …
The key point of the synthetic strategy was the use of commendamide t-butyl ester as a synthetic intermediate, a choice that allowed the rem …
Trastuzumab Potentiates Antitumor Activity of Thiopyrano[2,3-d]Thiazole Derivative in AGS Gastric Cancer Cells.
Roszczenko P, Szewczyk-Roszczenko OK, Gornowicz A, Czarnomysy R, Lozynskyi A, Bielawski K, Lesyk R, Bielawska A. Roszczenko P, et al. Molecules. 2024 Oct 30;29(21):5117. doi: 10.3390/molecules29215117. Molecules. 2024. PMID: 39519758 Free PMC article.
ELISA was employed to measure the levels of IL-6, p53, and cytochrome C. The combination of LES-6400 (1 M) and trastuzumab (10 g/mL) demonstrated superior antitumor activity compared to monotherapy with either agent in AGS gastric cancer cells. ...These findings indicate …
ELISA was employed to measure the levels of IL-6, p53, and cytochrome C. The combination of LES-6400 (1 M) and trastuzumab (10 g/mL …
21 results