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Discovery and characterization of a novel inhibitor of matrix metalloprotease-13 that reduces cartilage damage in vivo without joint fibroplasia side effects.
Johnson AR, Pavlovsky AG, Ortwine DF, Prior F, Man CF, Bornemeier DA, Banotai CA, Mueller WT, McConnell P, Yan C, Baragi V, Lesch C, Roark WH, Wilson M, Datta K, Guzman R, Han HK, Dyer RD. Johnson AR, et al. Among authors: lesch c. J Biol Chem. 2007 Sep 21;282(38):27781-91. doi: 10.1074/jbc.M703286200. Epub 2007 Jul 10. J Biol Chem. 2007. PMID: 17623656
Anaplerotic metabolism of alloreactive T cells provides a metabolic approach to treat graft-versus-host disease.
Glick GD, Rossignol R, Lyssiotis CA, Wahl D, Lesch C, Sanchez B, Liu X, Hao LY, Taylor C, Hurd A, Ferrara JL, Tkachev V, Byersdorfer CA, Boros L, Opipari AW. Glick GD, et al. Among authors: lesch c. J Pharmacol Exp Ther. 2014 Nov;351(2):298-307. doi: 10.1124/jpet.114.218099. Epub 2014 Aug 14. J Pharmacol Exp Ther. 2014. PMID: 25125579 Free PMC article.
32 results