Lesko LJ - Search Results

1

Improving drug safety with a systems pharmacology approach.

Schotland P, Bojunga N, Zien A, Trame MN, Lesko LJ. Schotland P, et al. Among authors: lesko lj. Eur J Pharm Sci. 2016 Oct 30;94:84-92. doi: 10.1016/j.ejps.2016.06.009. Epub 2016 Jun 7. Eur J Pharm Sci. 2016. PMID: 27287422

2

Systems pharmacology to predict drug safety in drug development.

Trame MN, Biliouris K, Lesko LJ, Mettetal JT. Trame MN, et al. Among authors: lesko lj. Eur J Pharm Sci. 2016 Oct 30;94:93-95. doi: 10.1016/j.ejps.2016.05.027. Epub 2016 May 29. Eur J Pharm Sci. 2016. PMID: 27251780 Review.

3

An Integrated Bioinformatics and Quantitative Modeling Approach to Investigate Potential Claims of Oral Generic Drug Product Bioinequivalence: Introduction.

Lesko LJ, Fang L, Schmidt S, Trame MN. Lesko LJ, et al. J Clin Pharmacol. 2019 Sep;59(9):1245-1248. doi: 10.1002/jcph.901. Epub 2019 May 14. J Clin Pharmacol. 2019. PMID: 31087551 No abstract available.

4

A case study of a patient-centered reverse translational systems-based approach to understand adverse event profiles in drug development.

Kim S, Lahu G, Vakilynejad M, Soldatos TG, Jackson DB, Lesko LJ, Trame MN. Kim S, et al. Among authors: lesko lj. Clin Transl Sci. 2022 Apr;15(4):1003-1013. doi: 10.1111/cts.13219. Epub 2022 Jan 11. Clin Transl Sci. 2022. PMID: 35014203 Free PMC article.

5

Application of a patient-centered reverse translational systems-based approach to understand mechanisms of an adverse drug reaction of immune checkpoint inhibitors.

Kim S, Lahu G, Vakilynejad M, Soldatos TG, Jackson DB, Lesko LJ, Trame MN. Kim S, et al. Among authors: lesko lj. Clin Transl Sci. 2022 Jun;15(6):1430-1438. doi: 10.1111/cts.13254. Epub 2022 Mar 5. Clin Transl Sci. 2022. PMID: 35191192 Free PMC article.

6

Sobol Sensitivity Analysis: A Tool to Guide the Development and Evaluation of Systems Pharmacology Models.

Zhang XY, Trame MN, Lesko LJ, Schmidt S. Zhang XY, et al. Among authors: lesko lj. CPT Pharmacometrics Syst Pharmacol. 2015 Feb;4(2):69-79. doi: 10.1002/psp4.6. CPT Pharmacometrics Syst Pharmacol. 2015. PMID: 27548289 Free PMC article.

7

Is Bioequivalence Established Based on the Reference-Scaled Average Bioequivalence Approach Relevant to Chronic Administration of Phenytoin? Perspectives Based on Population Pharmacokinetic Modeling and Simulations.

Kim H, Fang L, Yu J, Meng Z, Trame MN, Schmidt S, Lesko LJ, Zhao L. Kim H, et al. Among authors: lesko lj. J Clin Pharmacol. 2019 Aug;59(8):1061-1069. doi: 10.1002/jcph.1380. Epub 2019 Feb 4. J Clin Pharmacol. 2019. PMID: 30716169 Clinical Trial.

8

Quantitative Systems Pharmacology Model-Based Predictions of Clinical Endpoints to Optimize Warfarin and Rivaroxaban Anti-Thrombosis Therapy.

Hartmann S, Biliouris K, Lesko LJ, Nowak-Göttl U, Trame MN. Hartmann S, et al. Among authors: lesko lj. Front Pharmacol. 2020 Jul 14;11:1041. doi: 10.3389/fphar.2020.01041. eCollection 2020. Front Pharmacol. 2020. PMID: 32765265 Free PMC article.

9

Quantitative Systems Pharmacology Model to Predict the Effects of Commonly Used Anticoagulants on the Human Coagulation Network.

Hartmann S, Biliouris K, Lesko LJ, Nowak-Göttl U, Trame MN. Hartmann S, et al. Among authors: lesko lj. CPT Pharmacometrics Syst Pharmacol. 2016 Oct;5(10):554-564. doi: 10.1002/psp4.12111. Epub 2016 Sep 20. CPT Pharmacometrics Syst Pharmacol. 2016. PMID: 27647667 Free PMC article.

10

Physiologically Based Pharmacokinetic Modeling to Evaluate Formulation Factors Influencing Bioequivalence of Metoprolol Extended-Release Products.

Basu S, Yang H, Fang L, Gonzalez-Sales M, Zhao L, Trame MN, Lesko L, Schmidt S. Basu S, et al. J Clin Pharmacol. 2019 Sep;59(9):1252-1263. doi: 10.1002/jcph.1017. Epub 2019 May 14. J Clin Pharmacol. 2019. PMID: 31087553

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