Lesner A - Search Results

1

Sunflower trypsin inhibitor 1 as a molecular scaffold for drug discovery.

Lesner A, Łęgowska A, Wysocka M, Rolka K. Lesner A, et al. Curr Pharm Des. 2011 Dec;17(38):4308-17. doi: 10.2174/138161211798999393. Curr Pharm Des. 2011. PMID: 22204429 Review.

2

Distance between the basic group of the amino acid residue's side chain in position P1 of trypsin inhibitor CMTI-III and Asp189 in the substrate pocket of trypsin has an essential influence on the inhibitory activity.

Jaśkiewicz A, Lesner A, Rózycki J, Rodziewicz S, Rolka K, Ragnarsson U, Kupryszewski G. Jaśkiewicz A, et al. Among authors: lesner a. Biochem Biophys Res Commun. 1997 Nov 26;240(3):869-71. doi: 10.1006/bbrc.1997.7752. Biochem Biophys Res Commun. 1997. PMID: 9398660

3

Design, chemical synthesis and kinetic studies of trypsin chromogenic substrates based on the proteinase binding loop of Cucurbita maxima trypsin inhibitor (CMTI-III).

Lesner A, Brzozowski K, Kupryszewski G, Rolka K. Lesner A, et al. Biochem Biophys Res Commun. 2000 Mar 5;269(1):81-4. doi: 10.1006/bbrc.2000.2257. Biochem Biophys Res Commun. 2000. PMID: 10694481

4

Chromogenic substrates of bovine beta-trypsin: the influence of an amino acid residue in P1 position on their interaction with the enzyme.

Lesner A, Kupryszewski G, Rolka K. Lesner A, et al. Biochem Biophys Res Commun. 2001 Aug 3;285(5):1350-3. doi: 10.1006/bbrc.2001.5339. Biochem Biophys Res Commun. 2001. PMID: 11478806

5

Synthesis, activity on NK-3 tachykinin receptor and conformational solution studies of scyliorhinin II analogs modified at position 16.

Rodziewicz-Motowidło S, Lesner A, Łegowska A, Czaplewski C, Liwo A, Rolka K, Patacchini R, Quartara L. Rodziewicz-Motowidło S, et al. Among authors: lesner a. J Pept Res. 2001 Aug;58(2):159-72. doi: 10.1034/j.1399-3011.2001.00886.x. J Pept Res. 2001. PMID: 11532075

6

A simple method for selection of trypsin chromogenic substrates using combinatorial chemistry approach.

Zabłotna E, Dysasz H, Lesner A, Jaśkiewicz A, Kaźmierczak K, Miecznikowska H, Rolka K. Zabłotna E, et al. Among authors: lesner a. Biochem Biophys Res Commun. 2004 Jun 18;319(1):185-8. doi: 10.1016/j.bbrc.2004.04.170. Biochem Biophys Res Commun. 2004. PMID: 15158459

7

Selection of new chromogenic substrates of serine proteinases using combinatorial chemistry methods.

Wysocka M, Kwiatkowska B, Rzadkiewicz M, Lesner A, Rolka K. Wysocka M, et al. Among authors: lesner a. Comb Chem High Throughput Screen. 2007 Mar;10(3):171-80. doi: 10.2174/138620707780126714. Comb Chem High Throughput Screen. 2007. PMID: 17346116

8

Trypsin inhibitors from the garden four o'clock (Mirabilis jalapa) and spinach (Spinacia oleracea) seeds: isolation, characterization and chemical synthesis.

Kowalska J, Pszczoła K, Wilimowska-Pelc A, Lorenc-Kubis I, Zuziak E, Ługowski M, Łegowska A, Kwiatkowska A, Sleszyńska M, Lesner A, Walewska A, Zabłotna E, Rolka K, Wilusz T. Kowalska J, et al. Among authors: lesner a. Phytochemistry. 2007 Jun;68(11):1487-96. doi: 10.1016/j.phytochem.2007.03.012. Epub 2007 May 3. Phytochemistry. 2007. PMID: 17481678

9

New chromogenic substrates of human neutrophil cathepsin G containing non-natural aromatic amino acid residues in position P(1) selected by combinatorial chemistry methods.

Wysocka M, Legowska A, Bulak E, Jaśkiewicz A, Miecznikowska H, Lesner A, Rolka K. Wysocka M, et al. Among authors: lesner a. Mol Divers. 2007 May;11(2):93-9. doi: 10.1007/s11030-007-9063-7. Epub 2007 Jul 25. Mol Divers. 2007. PMID: 17653609

10

Design of serine proteinase inhibitors by combinatorial chemistry using trypsin inhibitor SFTI-1 as a starting structure.

Zabłotna E, Jaśkiewicz A, Łegowska A, Miecznikowska H, Lesner A, Rolka K. Zabłotna E, et al. Among authors: lesner a. J Pept Sci. 2007 Nov;13(11):749-55. doi: 10.1002/psc.887. J Pept Sci. 2007. PMID: 17828796

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