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2'-O-aminopropyl ribonucleotides: a zwitterionic modification that enhances the exonuclease resistance and biological activity of antisense oligonucleotides.
Griffey RH, Monia BP, Cummins LL, Freier S, Greig MJ, Guinosso CJ, Lesnik E, Manalili SM, Mohan V, Owens S, Ross BR, Sasmor H, Wancewicz E, Weiler K, Wheeler PD, Cook PD. Griffey RH, et al. Among authors: lesnik e. J Med Chem. 1996 Dec 20;39(26):5100-9. doi: 10.1021/jm950937o. J Med Chem. 1996. PMID: 8978841
2'-O-[2-(methylthio)ethyl]-modified oligonucleotide: an analogue of 2'-O-[2-(methoxy)-ethyl]-modified oligonucleotide with improved protein binding properties and high binding affinity to target RNA.
Prakash TP, Manoharan M, Kawasaki AM, Fraser AS, Lesnik EA, Sioufi N, Leeds JM, Teplova M, Egli M. Prakash TP, et al. Among authors: lesnik ea. Biochemistry. 2002 Oct 1;41(39):11642-8. doi: 10.1021/bi020264t. Biochemistry. 2002. PMID: 12269806
High-affinity peptide nucleic acid oligomers containing tricyclic cytosine analogues.
Rajeev KG, Maier MA, Lesnik EA, Manoharan M. Rajeev KG, et al. Among authors: lesnik ea. Org Lett. 2002 Dec 12;4(25):4395-8. doi: 10.1021/ol027026a. Org Lett. 2002. PMID: 12465896
Probing the influence of stereoelectronic effects on the biophysical properties of oligonucleotides: comprehensive analysis of the RNA affinity, nuclease resistance, and crystal structure of ten 2'-O-ribonucleic acid modifications.
Egli M, Minasov G, Tereshko V, Pallan PS, Teplova M, Inamati GB, Lesnik EA, Owens SR, Ross BS, Prakash TP, Manoharan M. Egli M, et al. Among authors: lesnik ea. Biochemistry. 2005 Jun 28;44(25):9045-57. doi: 10.1021/bi050574m. Biochemistry. 2005. PMID: 15966728
2'-O-[2-[N,N-(dialkyl)aminooxy]ethyl]-modified antisense oligonucleotides.
Prakash TP, Manoharan M, Kawasaki AM, Lesnik EA, Owens SR, Vasquez G. Prakash TP, et al. Among authors: lesnik ea. Org Lett. 2000 Dec 14;2(25):3995-8. doi: 10.1021/ol006555g. Org Lett. 2000. PMID: 11112626
Sequence-specific antitumor activity of a phosphorothioate oligodeoxyribonucleotide targeted to human C-raf kinase supports an antisense mechanism of action in vivo.
Monia BP, Sasmor H, Johnston JF, Freier SM, Lesnik EA, Muller M, Geiger T, Altmann KH, Moser H, Fabbro D. Monia BP, et al. Among authors: lesnik ea. Proc Natl Acad Sci U S A. 1996 Dec 24;93(26):15481-4. doi: 10.1073/pnas.93.26.15481. Proc Natl Acad Sci U S A. 1996. PMID: 8986837 Free PMC article.
Kinetic characteristics of Escherichia coli RNase H1: cleavage of various antisense oligonucleotide-RNA duplexes.
Crooke ST, Lemonidis KM, Neilson L, Griffey R, Lesnik EA, Monia BP. Crooke ST, et al. Among authors: lesnik ea. Biochem J. 1995 Dec 1;312 ( Pt 2)(Pt 2):599-608. doi: 10.1042/bj3120599. Biochem J. 1995. PMID: 8526876 Free PMC article.
Uniformly modified 2'-deoxy-2'-fluoro phosphorothioate oligonucleotides as nuclease-resistant antisense compounds with high affinity and specificity for RNA targets.
Kawasaki AM, Casper MD, Freier SM, Lesnik EA, Zounes MC, Cummins LL, Gonzalez C, Cook PD. Kawasaki AM, et al. Among authors: lesnik ea. J Med Chem. 1993 Apr 2;36(7):831-41. doi: 10.1021/jm00059a007. J Med Chem. 1993. PMID: 8464037
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