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Energy landscapes of receptor-ligand bonds explored with dynamic force spectroscopy.
Merkel R, Nassoy P, Leung A, Ritchie K, Evans E. Merkel R, et al. Among authors: leung a. Nature. 1999 Jan 7;397(6714):50-3. doi: 10.1038/16219. Nature. 1999. PMID: 9892352
But for weak noncovalent bonds, a dynamic spectrum of bond strengths is predicted as the loading rate is altered, with the measured strength being governed by the prominent barriers traversed in the energy landscape along the force-driven bond-dissociation pathway. In othe …
But for weak noncovalent bonds, a dynamic spectrum of bond strengths is predicted as the loading rate is altered, with the measured s …
Synchrony of cell spreading and contraction force as phagocytes engulf large pathogens.
Evans E, Leung A, Zhelev D. Evans E, et al. Among authors: leung a. J Cell Biol. 1993 Sep;122(6):1295-300. doi: 10.1083/jcb.122.6.1295. J Cell Biol. 1993. PMID: 8376464 Free PMC article.
A simple micromechanical method has been used to directly measure the force of contraction in single mammalian phagocytes (blood granulocytes) during engulfment of large yeast pathogens. ...The surprising feature of the phagocyte response was that engulfment and cell body
A simple micromechanical method has been used to directly measure the force of contraction in single mammalian phagocytes (blood gran
Detachment of agglutinin-bonded red blood cells. I. Forces to rupture molecular-point attachments.
Evans E, Berk D, Leung A. Evans E, et al. Among authors: leung a. Biophys J. 1991 Apr;59(4):838-48. doi: 10.1016/S0006-3495(91)82296-2. Biophys J. 1991. PMID: 2065188 Free PMC article.
In the procedure, one capsule is prepared with a low density coverage of adhesion molecules, formed as a stiff sphere, and held at fixed position by a micropipette. ...Here, the approach was used to study the forces required to rupture microscopic attachments …
In the procedure, one capsule is prepared with a low density coverage of adhesion molecules, formed as a stiff sphere, and hel …
Detachment of agglutinin-bonded red blood cells. II. Mechanical energies to separate large contact areas.
Evans E, Berk D, Leung A, Mohandas N. Evans E, et al. Among authors: leung a. Biophys J. 1991 Apr;59(4):849-60. doi: 10.1016/S0006-3495(91)82297-4. Biophys J. 1991. PMID: 2065189 Free PMC article.
As detailed in a companion paper (Berk, D., and E. Evans. 1991. Biophys. J. 59:861-872), a method was developed to quantitate the strength of adhesion between agglutinin-bonded membranes without ambiguity due to mechanical compliance of the cell body. The experiment …
As detailed in a companion paper (Berk, D., and E. Evans. 1991. Biophys. J. 59:861-872), a method was developed to quantitate …
Variations in regional cerebral blood volume in neonates associated with nursery care events.
Gagnon RE, Leung A, Macnab AJ. Gagnon RE, et al. Among authors: leung a. Am J Perinatol. 1999;16(1):7-11. doi: 10.1055/s-2007-993828. Am J Perinatol. 1999. PMID: 10362075 Clinical Trial.
These events produced 7-40% changes in blood volume for durations of 5-60 sec, and occurred at a rate of up to 45 events within a 2 hr period. ...
These events produced 7-40% changes in blood volume for durations of 5-60 sec, and occurred at a rate of up to 45 events within a
Biomembrane templates for nanoscale conduits and networks.
Evans E, Bowman H, Leung A, Needham D, Tirrell D. Evans E, et al. Among authors: leung a. Science. 1996 Aug 16;273(5277):933-5. doi: 10.1126/science.273.5277.933. Science. 1996. PMID: 8688071
Each nanotube is pulled from a micropipette-held feeder vesicle by mechanical retraction of the vesicle after molecular bonding to a rigid substrate. ...Single nanotubes and nanotube junctions can be linked together between bonding sites on a surface to creat …
Each nanotube is pulled from a micropipette-held feeder vesicle by mechanical retraction of the vesicle after molecular bonding to …
Intrathoracic paediatric tuberculosis: a report of 202 cases.
Pineda PR, Leung A, Muller NL, Allen EA, Black WA, FitzGerald JM. Pineda PR, et al. Among authors: leung a. Tuber Lung Dis. 1993 Aug;74(4):261-6. doi: 10.1016/0962-8479(93)90052-Y. Tuber Lung Dis. 1993. PMID: 8219178
Until recently paediatric tuberculosis rates were in decline in developed countries, but more recently there has been a significant change in these trends. ...A history of close contact was elicited in 158 children (78.2%). All but 8 (4%) had a positive PPD r …
Until recently paediatric tuberculosis rates were in decline in developed countries, but more recently there has been a significant c …
First branchial cleft fistula: case reports and literature review.
Noel F, Leung A. Noel F, et al. Among authors: leung a. J Otolaryngol. 1987 Aug;16(4):247-51. J Otolaryngol. 1987. PMID: 3656505
Three cases and a literature review are presented....
Three cases and a literature review are presented....
Nanoscale Reaction Vessels Designed for Synthesis of Copper-Drug Complexes Suitable for Preclinical Development.
Wehbe M, Anantha M, Backstrom I, Leung A, Chen K, Malhotra A, Edwards K, Bally MB. Wehbe M, et al. Among authors: leung a. PLoS One. 2016 Apr 7;11(4):e0153416. doi: 10.1371/journal.pone.0153416. eCollection 2016. PLoS One. 2016. PMID: 27055237 Free PMC article.
DDC crosses the liposomal lipid bilayer, reacting with the entrapped copper; a reaction that can be observed through a colour change as the solution goes from a light blue to dark brown. ...Our method provides a simple, transformative solution enabling …
DDC crosses the liposomal lipid bilayer, reacting with the entrapped copper; a reaction that can be observed through a colour …
Development and optimization of an injectable formulation of copper diethyldithiocarbamate, an active anticancer agent.
Wehbe M, Anantha M, Shi M, Leung AW, Dragowska WH, Sanche L, Bally MB. Wehbe M, et al. Among authors: leung aw. Int J Nanomedicine. 2017 May 31;12:4129-4146. doi: 10.2147/IJN.S137347. eCollection 2017. Int J Nanomedicine. 2017. PMID: 28615941 Free PMC article.
Convection-enhanced delivery of a Cu(DDC)(2) formulation prepared using 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC)/cholesterol liposomes into a rat model of F98 glioma engendered a 25% increase in median survival time relative to vehicle-treated animal …
Convection-enhanced delivery of a Cu(DDC)(2) formulation prepared using 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC)/cholesterol …
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