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Lipid nanoparticles for short interfering RNA delivery.
Leung AK, Tam YY, Cullis PR. Leung AK, et al. Adv Genet. 2014;88:71-110. doi: 10.1016/B978-0-12-800148-6.00004-3. Adv Genet. 2014. PMID: 25409604 Free PMC article. Review.
Bottom-up design and synthesis of limit size lipid nanoparticle systems with aqueous and triglyceride cores using millisecond microfluidic mixing.
Zhigaltsev IV, Belliveau N, Hafez I, Leung AK, Huft J, Hansen C, Cullis PR. Zhigaltsev IV, et al. Langmuir. 2012 Feb 21;28(7):3633-40. doi: 10.1021/la204833h. Epub 2012 Feb 9. Langmuir. 2012. PMID: 22268499
Development of lipid nanoparticle formulations of siRNA for hepatocyte gene silencing following subcutaneous administration.
Chen S, Tam YY, Lin PJ, Leung AK, Tam YK, Cullis PR. Chen S, et al. J Control Release. 2014 Dec 28;196:106-12. doi: 10.1016/j.jconrel.2014.09.025. Epub 2014 Oct 5. J Control Release. 2014. PMID: 25285610
Very Low Density Lipoprotein Receptor Sequesters Lipopolysaccharide Into Adipose Tissue During Sepsis.
Shimada T, Topchiy E, Leung AKK, Kong HJ, Genga KR, Boyd JH, Russell JA, Oda S, Nakada TA, Hirasawa H, Walley KR. Shimada T, et al. Crit Care Med. 2020 Jan;48(1):41-48. doi: 10.1097/CCM.0000000000004064. Crit Care Med. 2020. PMID: 31651422
Survival benefit of a low ratio of visceral to subcutaneous adipose tissue depends on LDL clearance versus production in sepsis.
Lee JGH, Genga KR, Pisitsak C, Boyd JH, Leung AKK, Russell JA, Walley KR. Lee JGH, et al. Crit Care. 2018 Mar 6;22(1):58. doi: 10.1186/s13054-018-1985-1. Crit Care. 2018. PMID: 29510719 Free PMC article.
CETP genetic variant rs1800777 (allele A) is associated with abnormally low HDL-C levels and increased risk of AKI during sepsis.
Genga KR, Trinder M, Kong HJ, Li X, Leung AKK, Shimada T, Walley KR, Russell JA, Francis GA, Brunham LR, Boyd JH. Genga KR, et al. Sci Rep. 2018 Nov 13;8(1):16764. doi: 10.1038/s41598-018-35261-2. Sci Rep. 2018. PMID: 30425299 Free PMC article.
Reduced Proprotein convertase subtilisin/kexin 9 (PCSK9) function increases lipoteichoic acid clearance and improves outcomes in Gram positive septic shock patients.
Leung AKK, Genga KR, Topchiy E, Cirstea M, Shimada T, Fjell C, Russell JA, Boyd JH, Walley KR. Leung AKK, et al. Sci Rep. 2019 Jul 22;9(1):10588. doi: 10.1038/s41598-019-46745-0. Sci Rep. 2019. PMID: 31332258 Free PMC article.
Lipid Nanoparticles Containing siRNA Synthesized by Microfluidic Mixing Exhibit an Electron-Dense Nanostructured Core.
Leung AK, Hafez IM, Baoukina S, Belliveau NM, Zhigaltsev IV, Afshinmanesh E, Tieleman DP, Hansen CL, Hope MJ, Cullis PR. Leung AK, et al. J Phys Chem C Nanomater Interfaces. 2012 Aug 30;116(34):18440-18450. doi: 10.1021/jp303267y. Epub 2012 Jul 18. J Phys Chem C Nanomater Interfaces. 2012. PMID: 22962627 Free PMC article.
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