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Targeting the EGFR-family for therapy: biological challenges and clinical perspective.
Patel R, Leung HY. Patel R, et al. Among authors: leung hy. Curr Pharm Des. 2012;18(19):2672-9. doi: 10.2174/138161212800626148. Curr Pharm Des. 2012. PMID: 22390755 Review.
Advances in mouse models of prostate cancer.
Ahmad I, Sansom OJ, Leung HY. Ahmad I, et al. Among authors: leung hy. Expert Rev Mol Med. 2008 Jun 9;10:e16. doi: 10.1017/S1462399408000689. Expert Rev Mol Med. 2008. PMID: 18538039 Review.
A phase I/II clinical trial in localized prostate cancer of an adenovirus expressing nitroreductase with CB1954 [correction of CB1984].
Patel P, Young JG, Mautner V, Ashdown D, Bonney S, Pineda RG, Collins SI, Searle PF, Hull D, Peers E, Chester J, Wallace DM, Doherty A, Leung H, Young LS, James ND. Patel P, et al. Among authors: leung h. Mol Ther. 2009 Jul;17(7):1292-9. doi: 10.1038/mt.2009.80. Epub 2009 Apr 14. Mol Ther. 2009. PMID: 19367257 Free PMC article. Clinical Trial.
SRC family kinase activity is up-regulated in hormone-refractory prostate cancer.
Tatarov O, Mitchell TJ, Seywright M, Leung HY, Brunton VG, Edwards J. Tatarov O, et al. Among authors: leung hy. Clin Cancer Res. 2009 May 15;15(10):3540-9. doi: 10.1158/1078-0432.CCR-08-1857. Epub 2009 May 15. Clin Cancer Res. 2009. PMID: 19447874
Alternative splicing and biological heterogeneity in prostate cancer.
Rajan P, Elliott DJ, Robson CN, Leung HY. Rajan P, et al. Among authors: leung hy. Nat Rev Urol. 2009 Aug;6(8):454-60. doi: 10.1038/nrurol.2009.125. Nat Rev Urol. 2009. PMID: 19657379 Review.
Signalling pathways in prostate carcinogenesis: potentials for molecular-targeted therapy.
Ramsay AK, Leung HY. Ramsay AK, et al. Among authors: leung hy. Clin Sci (Lond). 2009 Aug 14;117(6):209-28. doi: 10.1042/CS20080391. Clin Sci (Lond). 2009. PMID: 19663810 Review.
Tumor O(6)-methylguanine-DNA methyltransferase inactivation by oral lomeguatrib.
Watson AJ, Sabharwal A, Thorncroft M, McGown G, Kerr R, Bojanic S, Soonawalla Z, King A, Miller A, Waller S, Leung H, Margison GP, Middleton MR. Watson AJ, et al. Among authors: leung h. Clin Cancer Res. 2010 Jan 15;16(2):743-9. doi: 10.1158/1078-0432.CCR-09-1389. Epub 2010 Jan 12. Clin Cancer Res. 2010. PMID: 20068091 Free PMC article. Clinical Trial.
Docetaxel-resistant prostate cancer cells remain sensitive to S-trityl-L-cysteine-mediated Eg5 inhibition.
Wiltshire C, Singh BL, Stockley J, Fleming J, Doyle B, Barnetson R, Robson CN, Kozielski F, Leung HY. Wiltshire C, et al. Among authors: leung hy. Mol Cancer Ther. 2010 Jun;9(6):1730-9. doi: 10.1158/1535-7163.MCT-09-1103. Epub 2010 Jun 1. Mol Cancer Ther. 2010. PMID: 20515952
β-Catenin activation synergizes with PTEN loss to cause bladder cancer formation.
Ahmad I, Morton JP, Singh LB, Radulescu SM, Ridgway RA, Patel S, Woodgett J, Winton DJ, Taketo MM, Wu XR, Leung HY, Sansom OJ. Ahmad I, et al. Among authors: leung hy. Oncogene. 2011 Jan 13;30(2):178-89. doi: 10.1038/onc.2010.399. Epub 2010 Sep 6. Oncogene. 2011. PMID: 20818428 Free PMC article.
GRP78 up-regulation is associated with androgen receptor status, Hsp70-Hsp90 client proteins and castrate-resistant prostate cancer.
Tan SS, Ahmad I, Bennett HL, Singh L, Nixon C, Seywright M, Barnetson RJ, Edwards J, Leung HY. Tan SS, et al. Among authors: leung hy. J Pathol. 2011 Jan;223(1):81-7. doi: 10.1002/path.2795. Epub 2010 Oct 28. J Pathol. 2011. PMID: 21125667
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