Leung JW - Search Results

1

Nucleosome acidic patch promotes RNF168- and RING1B/BMI1-dependent H2AX and H2A ubiquitination and DNA damage signaling.

Leung JW, Agarwal P, Canny MD, Gong F, Robison AD, Finkelstein IJ, Durocher D, Miller KM. Leung JW, et al. PLoS Genet. 2014 Mar 6;10(3):e1004178. doi: 10.1371/journal.pgen.1004178. eCollection 2014 Mar. PLoS Genet. 2014. PMID: 24603765 Free PMC article.

2

Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination.

Gong F, Chiu LY, Cox B, Aymard F, Clouaire T, Leung JW, Cammarata M, Perez M, Agarwal P, Brodbelt JS, Legube G, Miller KM. Gong F, et al. Among authors: leung jw. Genes Dev. 2015 Jan 15;29(2):197-211. doi: 10.1101/gad.252189.114. Genes Dev. 2015. PMID: 25593309 Free PMC article.

3

Ubiquitin-Activated Interaction Traps (UBAITs) identify E3 ligase binding partners.

O'Connor HF, Lyon N, Leung JW, Agarwal P, Swaim CD, Miller KM, Huibregtse JM. O'Connor HF, et al. Among authors: leung jw. EMBO Rep. 2015 Dec;16(12):1699-712. doi: 10.15252/embr.201540620. Epub 2015 Oct 27. EMBO Rep. 2015. PMID: 26508657 Free PMC article.

4

ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair.

Leung JW, Makharashvili N, Agarwal P, Chiu LY, Pourpre R, Cammarata MB, Cannon JR, Sherker A, Durocher D, Brodbelt JS, Paull TT, Miller KM. Leung JW, et al. Genes Dev. 2017 Feb 1;31(3):260-274. doi: 10.1101/gad.292516.116. Epub 2017 Feb 27. Genes Dev. 2017. PMID: 28242625 Free PMC article.

5

CRISPR/Cas9 Gene Editing of Human Histone H2A Variant H2AX and MacroH2A.

Leung JWC, Emery LE, Miller KM. Leung JWC, et al. Methods Mol Biol. 2018;1832:255-269. doi: 10.1007/978-1-4939-8663-7_14. Methods Mol Biol. 2018. PMID: 30073532

6

ZMYM2 restricts 53BP1 at DNA double-strand breaks to favor BRCA1 loading and homologous recombination.

Lee D, Apelt K, Lee SO, Chan HR, Luijsterburg MS, Leung JWC, Miller KM. Lee D, et al. Nucleic Acids Res. 2022 Apr 22;50(7):3922-3943. doi: 10.1093/nar/gkac160. Nucleic Acids Res. 2022. PMID: 35253893 Free PMC article.

7

Sae2/CtIP prevents R-loop accumulation in eukaryotic cells.

Makharashvili N, Arora S, Yin Y, Fu Q, Wen X, Lee JH, Kao CH, Leung JW, Miller KM, Paull TT. Makharashvili N, et al. Among authors: leung jw. Elife. 2018 Dec 7;7:e42733. doi: 10.7554/eLife.42733. Elife. 2018. PMID: 30523780 Free PMC article.

8

Histone H2A variants alpha1-extension helix directs RNF168-mediated ubiquitination.

Kelliher JL, West KL, Gong Q, Leung JWC. Kelliher JL, et al. Nat Commun. 2020 May 18;11(1):2462. doi: 10.1038/s41467-020-16307-4. Nat Commun. 2020. PMID: 32424115 Free PMC article.

9

LC8/DYNLL1 is a 53BP1 effector and regulates checkpoint activation.

West KL, Kelliher JL, Xu Z, An L, Reed MR, Eoff RL, Wang J, Huen MSY, Leung JWC. West KL, et al. Nucleic Acids Res. 2019 Jul 9;47(12):6236-6249. doi: 10.1093/nar/gkz263. Nucleic Acids Res. 2019. PMID: 30982887 Free PMC article.

10

Regulation of chromatin architecture by the PWWP domain-containing DNA damage-responsive factor EXPAND1/MUM1.

Huen MS, Huang J, Leung JW, Sy SM, Leung KM, Ching YP, Tsao SW, Chen J. Huen MS, et al. Among authors: leung jw, leung km. Mol Cell. 2010 Mar 26;37(6):854-64. doi: 10.1016/j.molcel.2009.12.040. Mol Cell. 2010. PMID: 20347427 Free PMC article.

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