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Year Number of Results
1969 3
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1978 30
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1980 58
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1983 105
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1987 134
1988 140
1989 137
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1992 131
1993 96
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1998 138
1999 151
2000 160
2001 157
2002 147
2003 193
2004 177
2005 172
2006 210
2007 214
2008 208
2009 196
2010 227
2011 224
2012 205
2013 180
2014 148
2015 144
2016 112
2017 108
2018 97
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5,722 results

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Page 1
Mechanism of Microbial Metabolite Leupeptin in the Treatment of COVID-19 by Traditional Chinese Medicine Herbs.
Fu L, Shao S, Feng Y, Ye F, Sun X, Wang Q, Yu F, Wang Q, Huang B, Niu P, Li X, Wong CCL, Qi J, Tan W, Gao GF. Fu L, et al. mBio. 2021 Oct 26;12(5):e0222021. doi: 10.1128/mBio.02220-21. Epub 2021 Sep 28. mBio. 2021. PMID: 34579576 Free PMC article.
In addition, leupeptin can also inhibit SARS-CoV-2 in Vero cells, with 50% effective concentration (EC(50)) values of 42.34 muM. ...Moreover, leupeptin found in the QFPD decoction was confirmed by both HPLC fingerprinting and HRMS. ...
In addition, leupeptin can also inhibit SARS-CoV-2 in Vero cells, with 50% effective concentration (EC(50)) values of 42.34 muM. ...M …
Leupeptin-based inhibitors do not improve the mdx phenotype.
Selsby J, Pendrak K, Zadel M, Tian Z, Pham J, Carver T, Acosta P, Barton E, Sweeney HL. Selsby J, et al. Am J Physiol Regul Integr Comp Physiol. 2010 Nov;299(5):R1192-201. doi: 10.1152/ajpregu.00586.2009. Epub 2010 Sep 15. Am J Physiol Regul Integr Comp Physiol. 2010. PMID: 20844259 Free PMC article.
We compared the effects of pharmacological calpain inhibition in the mdx mouse using leupeptin and a proprietary compound (C101) that linked the inhibitory portion of leupeptin to carnitine (to increase uptake into muscle). ...Biochemical analysis revealed that l …
We compared the effects of pharmacological calpain inhibition in the mdx mouse using leupeptin and a proprietary compound (C101) that …
Gelatin Zymography Using Leupeptin for the Detection of Various Cathepsin L Forms.
Hashimoto Y. Hashimoto Y. Methods Mol Biol. 2017;1594:243-254. doi: 10.1007/978-1-4939-6934-0_16. Methods Mol Biol. 2017. PMID: 28456988
Moreover, leupeptin can be easily removed from the complex because it is a reversibly binding inhibitor. In addition, leupeptin is too small to influence the electrode migration distance of the complex with cathepsin L on a sodium dodecyl sulfate-polyacrylamide gel. …
Moreover, leupeptin can be easily removed from the complex because it is a reversibly binding inhibitor. In addition, leupeptin …
Leupeptin inhibits phospholipases D and C activation in rat hepatocytes.
Benistant C, Moehren G, Gustavsson L, Torres-Marquez E, Hoek JB, Rubin R. Benistant C, et al. Biochim Biophys Acta. 1994 Aug 11;1223(1):84-90. doi: 10.1016/0167-4889(94)90076-0. Biochim Biophys Acta. 1994. PMID: 8061057
Leupeptin also inhibited the formation of inositol phosphates in intact cells in response to vasopressin. ...Plasma membrane-associated phospholipase D did not require calcium and was insensitive to protein kinase C inhibitors. Leupeptin inhibited PETH formation in …
Leupeptin also inhibited the formation of inositol phosphates in intact cells in response to vasopressin. ...Plasma membrane-associat …
Characterization of the leupeptin-inactivating enzyme from Streptomyces exfoliatus SMF13 which produces leupeptin.
Kim IS, Kim YB, Lee KJ. Kim IS, et al. Biochem J. 1998 Apr 15;331 ( Pt 2)(Pt 2):539-45. doi: 10.1042/bj3310539. Biochem J. 1998. PMID: 9531495 Free PMC article.
Acetyl-leucine, leucine and argininal were identified as the products of leupeptin inactivated by the LIE, indicating that leupeptin is inactivated by hydrolysis of peptide bond between leucine and leucine and between leucine and argininal of leupeptin (acety …
Acetyl-leucine, leucine and argininal were identified as the products of leupeptin inactivated by the LIE, indicating that leupept …
Leupeptin as a tool for the detection of the sites of catabolism of rat high-density lipoprotein apolipoproteins A-I and E.
van 't Hooft FM, Dallinga-Thie GM, van Tol A. van 't Hooft FM, et al. Biochim Biophys Acta. 1985 Mar 27;834(1):75-84. doi: 10.1016/0005-2760(85)90178-x. Biochim Biophys Acta. 1985. PMID: 2579677
Leupeptin, an inhibitor of lysosomal cathepsin activity, was injected intravenously into male rats. Tissues obtained from leupeptin-treated animals showed a depressed cathepsin activity when compared with tissues from saline-treated control animals. ...
Leupeptin, an inhibitor of lysosomal cathepsin activity, was injected intravenously into male rats. Tissues obtained from leupepti …
Leupeptin, a calpain inhibitor, protects inner ear hair cells from aminoglycoside ototoxicity.
Momiyama J, Hashimoto T, Matsubara A, Futai K, Namba A, Shinkawa H. Momiyama J, et al. Tohoku J Exp Med. 2006 Jun;209(2):89-97. doi: 10.1620/tjem.209.89. Tohoku J Exp Med. 2006. PMID: 16707850 Free article.
We demonstrated that neomycin (0.1-1 mM) reduced the number of outer hair cells in a dose-dependent manner. Furthermore, we showed that leupeptin, a calpain inhibitor, significantly protects against the neomycin-induced loss of outer hair cells, whereas a caspase inhibitor …
We demonstrated that neomycin (0.1-1 mM) reduced the number of outer hair cells in a dose-dependent manner. Furthermore, we showed that l …
Strong Binding of Leupeptin with TMPRSS2 Protease May Be an Alternative to Camostat and Nafamostat for SARS-CoV-2 Repurposed Drug: Evaluation from Molecular Docking and Molecular Dynamics Simulations.
Ramakrishnan J, Kandasamy S, Iruthayaraj A, Magudeeswaran S, Chinnasamy K, Poomani K. Ramakrishnan J, et al. Appl Biochem Biotechnol. 2021 Jun;193(6):1909-1923. doi: 10.1007/s12010-020-03475-8. Epub 2021 Jan 29. Appl Biochem Biotechnol. 2021. PMID: 33512650 Free PMC article.
Several drug targets have been reported to inhibit the SARS-CoV-2 virus infection, in that TMPRSS2 (transmembrane protease serine 2) is one of the potential targets; inhibiting this protease stops the virus entry into the host human cell. Camostat mesylate, nafamostat, and leu …
Several drug targets have been reported to inhibit the SARS-CoV-2 virus infection, in that TMPRSS2 (transmembrane protease serine 2) is one …
Leupeptin protects sensory hair cells from acoustic trauma.
Wang J, Ding D, Shulman A, Stracher A, Salvi RJ. Wang J, et al. Neuroreport. 1999 Mar 17;10(4):811-6. doi: 10.1097/00001756-199903170-00027. Neuroreport. 1999. PMID: 10208553
Calpain inhibitors attenuate some neurodegenerative processes in certain cell types. Here we show that leupeptin, a potent calpain inhibitor, protects the sensory hair cells in the inner ear from acoustic overstimulation (48 h, 100 or 105 dB SPL, octave band noise at 4 kHz …
Calpain inhibitors attenuate some neurodegenerative processes in certain cell types. Here we show that leupeptin, a potent calpain in …
Leupeptin enhances cell surface localization of fibroblast growth factor receptor 1 in adult sensory neurons by increased recycling.
Hausott B, Vallant N, Hochfilzer M, Mangger S, Irschick R, Haugsten EM, Klimaschewski L. Hausott B, et al. Eur J Cell Biol. 2012 Feb;91(2):129-38. doi: 10.1016/j.ejcb.2011.09.009. Epub 2011 Dec 9. Eur J Cell Biol. 2012. PMID: 22169219
Therefore, we analyzed the effects of leupeptin on intracellular sorting of FGFR1 in PC12 pheochromocytoma cells and DRG neurons. Leupeptin increased colocalization of FGFR1 with lysosomes. Furthermore, leupeptin enhanced the cell surface localization of FGFR …
Therefore, we analyzed the effects of leupeptin on intracellular sorting of FGFR1 in PC12 pheochromocytoma cells and DRG neurons. …
5,722 results