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373 results
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A "locked-on," constitutively active mutant of the adenosine A1 receptor.
de Ligt RA, Rivkees SA, Lorenzen A, Leurs R, IJzerman AP. de Ligt RA, et al. Among authors: leurs r. Eur J Pharmacol. 2005 Mar 7;510(1-2):1-8. doi: 10.1016/j.ejphar.2005.01.007. Eur J Pharmacol. 2005. PMID: 15740718
Desensitization of histamine H1 receptor-mediated cyclic GMP production in guinea-pig lung.
Leurs R, Brozius MM, Jansen W, Bast A, Timmerman H. Leurs R, et al. Eur J Pharmacol. 1992 Feb 13;225(2):137-41. doi: 10.1016/0922-4106(92)90093-b. Eur J Pharmacol. 1992. PMID: 1312939
Short-term desensitization of the histamine H1 receptor in human HeLa cells: involvement of protein kinase C dependent and independent pathways.
Smit MJ, Bloemers SM, Leurs R, Tertoolen LG, Bast A, de Laat SW, Timmerman H. Smit MJ, et al. Among authors: leurs r. Br J Pharmacol. 1992 Oct;107(2):448-55. doi: 10.1111/j.1476-5381.1992.tb12766.x. Br J Pharmacol. 1992. PMID: 1422591 Free PMC article.
Effects of histamine H1-, H2- and H3-receptor selective drugs on the mechanical activity of guinea-pig small and large intestine.
Leurs R, Brozius MM, Smit MJ, Bast A, Timmerman H. Leurs R, et al. Br J Pharmacol. 1991 Jan;102(1):179-85. doi: 10.1111/j.1476-5381.1991.tb12150.x. Br J Pharmacol. 1991. PMID: 1646056 Free PMC article.
Histamine H1-receptor-mediated cyclic GMP production in guinea-pig lung tissue is an L-arginine-dependent process.
Leurs R, Brozius MM, Jansen W, Bast A, Timmerman H. Leurs R, et al. Biochem Pharmacol. 1991 Jul 5;42(2):271-7. doi: 10.1016/0006-2952(91)90713-f. Biochem Pharmacol. 1991. PMID: 1650206
Homologous histamine H1 receptor desensitization results in reduction of H1 receptor agonist efficacy.
Leurs R, Smit MJ, Bast A, Timmerman H. Leurs R, et al. Eur J Pharmacol. 1991 Apr 24;196(3):319-22. doi: 10.1016/0014-2999(91)90446-w. Eur J Pharmacol. 1991. PMID: 1654256
Fluoride is a contractile agent of guinea pig airway smooth muscle.
Leurs R, Bast A, Timmerman H. Leurs R, et al. Gen Pharmacol. 1991;22(4):631-6. doi: 10.1016/0306-3623(91)90068-h. Gen Pharmacol. 1991. PMID: 1657687
Ebselen inhibits contractile responses of guinea-pig parenchymal lung strips.
Leurs R, Bast A, Timmerman H. Leurs R, et al. Eur J Pharmacol. 1990 Apr 10;179(1-2):193-9. doi: 10.1016/0014-2999(90)90418-6. Eur J Pharmacol. 1990. PMID: 2114294
Histamine receptors: subclasses and specific ligands.
Haaksma EE, Leurs R, Timmerman H. Haaksma EE, et al. Among authors: leurs r. Pharmacol Ther. 1990;47(1):73-104. doi: 10.1016/0163-7258(90)90046-5. Pharmacol Ther. 1990. PMID: 2195558 Review.
High affinity, saturable [3H]mepyramine binding sites on rat liver plasma membrane do not represent histamine H1-receptors. A warning.
Leurs R, Bast A, Timmerman H. Leurs R, et al. Biochem Pharmacol. 1989 Jul 1;38(13):2175-80. doi: 10.1016/0006-2952(89)90073-7. Biochem Pharmacol. 1989. PMID: 2567596
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