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Human prostate cancer cells and xenografts are targeted and destroyed through luteinizing hormone releasing hormone receptors.
Leuschner C, Enright FM, Gawronska-Kozak B, Hansel W. Leuschner C, et al. Prostate. 2003 Sep 1;56(4):239-49. doi: 10.1002/pros.10259. Prostate. 2003. PMID: 12858351
LHRH-conjugated magnetic iron oxide nanoparticles for detection of breast cancer metastases.
Leuschner C, Kumar CS, Hansel W, Soboyejo W, Zhou J, Hormes J. Leuschner C, et al. Breast Cancer Res Treat. 2006 Sep;99(2):163-76. doi: 10.1007/s10549-006-9199-7. Epub 2006 Jun 3. Breast Cancer Res Treat. 2006. PMID: 16752077
Incubations at 4 degrees C resulted in 1.1 pg Fe/cell. Co-incubation with the same ligands (betaCG or LHRH) decreased the iron accumulation in each case. ...
Incubations at 4 degrees C resulted in 1.1 pg Fe/cell. Co-incubation with the same ligands (betaCG or LHRH) decreased the iron accumu …
Glutaric acid as a spacer facilitates improved intracellular uptake of LHRH-SPION into human breast cancer cells.
Kumar CS, Leuschner C, Urbina M, Ozkaya T, Hormes J. Kumar CS, et al. Among authors: leuschner c. Int J Nanomedicine. 2007;2(2):175-9. Int J Nanomedicine. 2007. PMID: 17722545 Free PMC article.
Effective treatment of human breast tumor in a mouse xenograft model with herpes simplex virus type 1 specifying the NV1020 genomic deletion and the gBsyn3 syncytial mutation enabling high viral replication and spread in breast cancer cells.
Israyelyan AH, Melancon JM, Lomax LG, Sehgal I, Leuschner C, Kearney MT, Chouljenko VN, Baghian A, Kousoulas KG. Israyelyan AH, et al. Among authors: leuschner c. Hum Gene Ther. 2007 May;18(5):457-73. doi: 10.1089/hum.2006.145. Hum Gene Ther. 2007. PMID: 17536976
Conjugates of lytic peptides and LHRH or betaCG target and cause necrosis of prostate cancers and metastases.
Hansel W, Leuschner C, Enright F. Hansel W, et al. Among authors: leuschner c. Mol Cell Endocrinol. 2007 Apr 15;269(1-2):26-33. doi: 10.1016/j.mce.2006.06.017. Epub 2007 Feb 15. Mol Cell Endocrinol. 2007. PMID: 17382461 Review.
Destruction of breast cancers and their metastases by lytic peptide conjugates in vitro and in vivo.
Hansel W, Enright F, Leuschner C. Hansel W, et al. Among authors: leuschner c. Mol Cell Endocrinol. 2007 Jan 2;260-262:183-9. doi: 10.1016/j.mce.2005.12.056. Epub 2006 Nov 13. Mol Cell Endocrinol. 2007. PMID: 17101210
Targeting breast and prostate cancers through their hormone receptors.
Leuschner C, Hansel W. Leuschner C, et al. Biol Reprod. 2005 Nov;73(5):860-5. doi: 10.1095/biolreprod.105.043471. Epub 2005 Jul 20. Biol Reprod. 2005. PMID: 16033998 Review.
Membrane disrupting lytic peptides for cancer treatments.
Leuschner C, Hansel W. Leuschner C, et al. Curr Pharm Des. 2004;10(19):2299-310. doi: 10.2174/1381612043383971. Curr Pharm Des. 2004. PMID: 15279610 Review.
Efficacy of lytic peptide-bound magnetite nanoparticles in destroying breast cancer cells.
Kumar CS, Leuschner C, Doomes EE, Henry L, Juban M, Hormes J. Kumar CS, et al. Among authors: leuschner c. J Nanosci Nanotechnol. 2004 Mar;4(3):245-9. J Nanosci Nanotechnol. 2004. PMID: 15233083
Effects of a lytic peptide conjugated to beta HCG on ovarian cancer: studies in vitro and in vivo.
Gawronska B, Leuschner C, Enright FM, Hansel W. Gawronska B, et al. Among authors: leuschner c. Gynecol Oncol. 2002 Apr;85(1):45-52. doi: 10.1006/gyno.2001.6558. Gynecol Oncol. 2002. PMID: 11925119
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