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Discovery of P450-Modified Sesquiterpenoids Levinoids A-D through Global Genome Mining.
Liu W, Tian X, Huang X, Malit JJL, Wu C, Guo Z, Tang JW, Qian PY. Liu W, et al. J Nat Prod. 2024 Feb 20. doi: 10.1021/acs.jnatprod.3c01136. Online ahead of print. J Nat Prod. 2024. PMID: 38377956
Among these, we selected 562 with multiple P450 enzymes, which were further clustered as 355 gene cluster families by sequence similarity analysis. We then chose lev, a BGC from Streptomyces levis MCCC1A01616, for heterologous expression and discovered four new alpha-amorp …
Among these, we selected 562 with multiple P450 enzymes, which were further clustered as 355 gene cluster families by sequence similarity an …
New flexible synthesis of pyrazoles with different, functionalized substituents at C3 and C5.
Grotjahn DB, Van S, Combs D, Lev DA, Schneider C, Rideout M, Meyer C, Hernandez G, Mejorado L. Grotjahn DB, et al. J Org Chem. 2002 Dec 27;67(26):9200-9. doi: 10.1021/jo026083e. J Org Chem. 2002. PMID: 12492321
Alcohol deprotection and conversion to a chloride gave 5-substituted 3-(chloromethyl)- or 3-(2-chloroethyl)pyrazoles. This sequence can be done within 2 d on a 30 g scale in excellent overall yield. Through nucleophilic substitution reactions, the chlorides are useful prec …
Alcohol deprotection and conversion to a chloride gave 5-substituted 3-(chloromethyl)- or 3-(2-chloroethyl)pyrazoles. This sequence can be d …