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Resveratrol and prostate cancer: promising role for microRNAs.
Dhar S, Hicks C, Levenson AS. Dhar S, et al. Mol Nutr Food Res. 2011 Aug;55(8):1219-29. doi: 10.1002/mnfr.201100141. Epub 2011 Jun 29. Mol Nutr Food Res. 2011. PMID: 21714127
Resveratrol enhances p53 acetylation and apoptosis in prostate cancer by inhibiting MTA1/NuRD complex.
Kai L, Samuel SK, Levenson AS. Kai L, et al. Int J Cancer. 2010 Apr 1;126(7):1538-48. doi: 10.1002/ijc.24928. Int J Cancer. 2010. PMID: 19810103
Our study identifies MTA1 as a new molecular target of Res that may have important clinical applications for PCa chemoprevention and therapy, and points to the combination of Res with HDAC inhibitors as an innovative therapeutic strategy for the treatment of PCa....
Our study identifies MTA1 as a new molecular target of Res that may have important clinical applications for PCa chemoprevention and …
Identification of a unique set of genes altered during cell-cell contact in an in vitro model of prostate cancer bone metastasis.
Wang J, Levenson AS, Satcher RL Jr. Wang J, et al. Int J Mol Med. 2006 May;17(5):849-56. Int J Mol Med. 2006. PMID: 16596270
Among genes that were modified by both soluble factors and physical contact, the gene expression was affected in the same direction (such as MKK4) or in the opposite direction (such as TGFbeta receptor 3). Overall, this suggests that heterotypic cell-cell contact ma …
Among genes that were modified by both soluble factors and physical contact, the gene expression was affected in the same direction (such …
Estrogenic effects of resveratrol in breast cancer cells expressing mutant and wild-type estrogen receptors: role of AF-1 and AF-2.
Gehm BD, Levenson AS, Liu H, Lee EJ, Amundsen BM, Cushman M, Jordan VC, Jameson JL. Gehm BD, et al. J Steroid Biochem Mol Biol. 2004 Mar;88(3):223-34. doi: 10.1016/j.jsbmb.2003.12.002. J Steroid Biochem Mol Biol. 2004. PMID: 15120416
Resveratrol, a hydroxystilbene found in grapes and wine, has previously been shown to be a non-flavonoid phytoestrogen, and to act as an estrogen receptor (ER) superagonist in MCF-7 cells transiently transfected with estrogen-responsive reporter constructs. ...In TGFalpha …
Resveratrol, a hydroxystilbene found in grapes and wine, has previously been shown to be a non-flavonoid phytoestrogen, and to act as
Resveratrol acts as an estrogen receptor (ER) agonist in breast cancer cells stably transfected with ER alpha.
Levenson AS, Gehm BD, Pearce ST, Horiguchi J, Simons LA, Ward JE 3rd, Jameson JL, Jordan VC. Levenson AS, et al. Int J Cancer. 2003 May 1;104(5):587-96. doi: 10.1002/ijc.10992. Int J Cancer. 2003. PMID: 12594813
Res has been shown to function as an estrogen receptor (ER) agonist, but it remains unclear whether it may also exert antagonist activity. ...TGFalpha mRNA induction was used as a specific marker of estradiol (E(2)) responsiveness. Res caused a concentration-depende …
Res has been shown to function as an estrogen receptor (ER) agonist, but it remains unclear whether it may also exert antagonist acti …
MTA1 drives malignant progression and bone metastasis in prostate cancer.
Kumar A, Dhar S, Campanelli G, Butt NA, Schallheim JM, Gomez CR, Levenson AS. Kumar A, et al. Among authors: levenson as. Mol Oncol. 2018 Sep;12(9):1596-1607. doi: 10.1002/1878-0261.12360. Epub 2018 Aug 14. Mol Oncol. 2018. PMID: 30027683 Free PMC article.
Pterostilbene inhibits MTA1/HDAC1 complex leading to PTEN acetylation in hepatocellular carcinoma.
Qian YY, Liu ZS, Yan HJ, Yuan YF, Levenson AS, Li K. Qian YY, et al. Among authors: levenson as. Biomed Pharmacother. 2018 May;101:852-859. doi: 10.1016/j.biopha.2018.03.022. Epub 2018 Mar 22. Biomed Pharmacother. 2018. PMID: 29635894
Pterostilbene increases PTEN expression through the targeted downregulation of microRNA-19a in hepatocellular carcinoma.
Qian YY, Liu ZS, Zhang Z, Levenson AS, Li K. Qian YY, et al. Among authors: levenson as. Mol Med Rep. 2018 Apr;17(4):5193-5201. doi: 10.3892/mmr.2018.8515. Epub 2018 Jan 29. Mol Med Rep. 2018. PMID: 29393488 Free PMC article.
Targeting MTA1/HIF-1α signaling by pterostilbene in combination with histone deacetylase inhibitor attenuates prostate cancer progression.
Butt NA, Kumar A, Dhar S, Rimando AM, Akhtar I, Hancock JC, Lage JM, Pound CR, Lewin JR, Gomez CR, Levenson AS. Butt NA, et al. Among authors: levenson as. Cancer Med. 2017 Nov;6(11):2673-2685. doi: 10.1002/cam4.1209. Epub 2017 Oct 10. Cancer Med. 2017. PMID: 29024573 Free PMC article.
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