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HRAS-driven cancer cells are vulnerable to TRPML1 inhibition.
Jung J, Cho KJ, Naji AK, Clemons KN, Wong CO, Villanueva M, Gregory S, Karagas NE, Tan L, Liang H, Rousseau MA, Tomasevich KM, Sikora AG, Levental I, van der Hoeven D, Zhou Y, Hancock JF, Venkatachalam K. Jung J, et al. Among authors: levental i. EMBO Rep. 2019 Apr;20(4):e46685. doi: 10.15252/embr.201846685. Epub 2019 Feb 20. EMBO Rep. 2019. PMID: 30787043 Free PMC article.
Lipin-1 regulation of phospholipid synthesis maintains endoplasmic reticulum homeostasis and is critical for triple-negative breast cancer cell survival.
He J, Zhang F, Tay LWR, Boroda S, Nian W, Levental KR, Levental I, Harris TE, Chang JT, Du G. He J, et al. Among authors: levental kr, levental i. FASEB J. 2017 Jul;31(7):2893-2904. doi: 10.1096/fj.201601353R. Epub 2017 Mar 27. FASEB J. 2017. PMID: 28347999 Free PMC article.
Our results suggest that lipin-1 is a potential target for cancer therapy.-He, J., Zhang, F., Tay, L. W. R., Boroda, S., Nian, W., Levental, K. R., Levental, I., Harris, T. E., Chang, J. T., Du, G. ...
Our results suggest that lipin-1 is a potential target for cancer therapy.-He, J., Zhang, F., Tay, L. W. R., Boroda, S., Nian, W., Levent …
Membrane raft association is a determinant of plasma membrane localization.
Diaz-Rohrer BB, Levental KR, Simons K, Levental I. Diaz-Rohrer BB, et al. Among authors: levental kr, levental i. Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):8500-5. doi: 10.1073/pnas.1404582111. Epub 2014 May 27. Proc Natl Acad Sci U S A. 2014. PMID: 24912166 Free PMC article.
The Continuing Mystery of Lipid Rafts.
Levental I, Veatch S. Levental I, et al. J Mol Biol. 2016 Dec 4;428(24 Pt A):4749-4764. doi: 10.1016/j.jmb.2016.08.022. Epub 2016 Aug 26. J Mol Biol. 2016. PMID: 27575334 Free PMC article. Review.
97 results