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Carboxyl-terminal fragments of Alzheimer beta-amyloid precursor protein accumulate in restricted and unpredicted intracellular compartments in presenilin 1-deficient cells.
Chen F, Yang DS, Petanceska S, Yang A, Tandon A, Yu G, Rozmahel R, Ghiso J, Nishimura M, Zhang DM, Kawarai T, Levesque G, Mills J, Levesque L, Song YQ, Rogaeva E, Westaway D, Mount H, Gandy S, St George-Hyslop P, Fraser PE. Chen F, et al. Among authors: levesque l, levesque g. J Biol Chem. 2000 Nov 24;275(47):36794-802. doi: 10.1074/jbc.M006986200. J Biol Chem. 2000. PMID: 10962005 Free article.
Biochemistry of Alzheimer's disease amyloid plaques.
Fraser PE, Lévesque L, McLachlan DR. Fraser PE, et al. Among authors: levesque l. Clin Biochem. 1993 Oct;26(5):339-49. doi: 10.1016/0009-9120(93)90110-r. Clin Biochem. 1993. PMID: 8299204 Review.
Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of beta-catenin, a component of the presenilin protein complex.
Nishimura M, Yu G, Levesque G, Zhang DM, Ruel L, Chen F, Milman P, Holmes E, Liang Y, Kawarai T, Jo E, Supala A, Rogaeva E, Xu DM, Janus C, Levesque L, Bi Q, Duthie M, Rozmahel R, Mattila K, Lannfelt L, Westaway D, Mount HT, Woodgett J, St George-Hyslop P, et al. Nishimura M, et al. Among authors: levesque l, levesque g. Nat Med. 1999 Feb;5(2):164-9. doi: 10.1038/5526. Nat Med. 1999. PMID: 9930863
Presenilin structure, function and role in Alzheimer disease.
Fraser PE, Yang DS, Yu G, Lévesque L, Nishimura M, Arawaka S, Serpell LC, Rogaeva E, St George-Hyslop P. Fraser PE, et al. Among authors: levesque l. Biochim Biophys Acta. 2000 Jul 26;1502(1):1-15. doi: 10.1016/s0925-4439(00)00028-4. Biochim Biophys Acta. 2000. PMID: 10899427 Free article. Review.
Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing.
Yu G, Nishimura M, Arawaka S, Levitan D, Zhang L, Tandon A, Song YQ, Rogaeva E, Chen F, Kawarai T, Supala A, Levesque L, Yu H, Yang DS, Holmes E, Milman P, Liang Y, Zhang DM, Xu DH, Sato C, Rogaev E, Smith M, Janus C, Zhang Y, Aebersold R, Farrer LS, Sorbi S, Bruni A, Fraser P, St George-Hyslop P. Yu G, et al. Among authors: levesque l. Nature. 2000 Sep 7;407(6800):48-54. doi: 10.1038/35024009. Nature. 2000. PMID: 10993067
Two homologous genes causing early-onset familial Alzheimer's disease.
St George-Hyslop PH, Levesque G, Levesque L, Rommens J, Westaway D, Fraser PE. St George-Hyslop PH, et al. Among authors: levesque l, levesque g. Cold Spring Harb Symp Quant Biol. 1996;61:559-64. Cold Spring Harb Symp Quant Biol. 1996. PMID: 9246482 No abstract available.
Presenilins interact with armadillo proteins including neural-specific plakophilin-related protein and beta-catenin.
Levesque G, Yu G, Nishimura M, Zhang DM, Levesque L, Yu H, Xu D, Liang Y, Rogaeva E, Ikeda M, Duthie M, Murgolo N, Wang L, VanderVere P, Bayne ML, Strader CD, Rommens JM, Fraser PE, St George-Hyslop P. Levesque G, et al. Among authors: levesque l. J Neurochem. 1999 Mar;72(3):999-1008. doi: 10.1046/j.1471-4159.1999.0720999.x. J Neurochem. 1999. PMID: 10037471 Free article.
283 results