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2008 1
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Page 1
Metabolic basis to Sherpa altitude adaptation.
Horscroft JA, Kotwica AO, Laner V, West JA, Hennis PJ, Levett DZH, Howard DJ, Fernandez BO, Burgess SL, Ament Z, Gilbert-Kawai ET, Vercueil A, Landis BD, Mitchell K, Mythen MG, Branco C, Johnson RS, Feelisch M, Montgomery HE, Griffin JL, Grocott MPW, Gnaiger E, Martin DS, Murray AJ. Horscroft JA, et al. Among authors: Levett DZH. Proc Natl Acad Sci U S A. 2017 Jun 13;114(24):6382-6387. doi: 10.1073/pnas.1700527114. Epub 2017 May 22. Proc Natl Acad Sci U S A. 2017. PMID: 28533386 Free PMC article.
The Himalayan Sherpas, a human population of Tibetan descent, are highly adapted to life in the hypobaric hypoxia of high altitude. ...Our findings suggest that metabolic adaptations underpin human evolution to life at high altitude, and could have an impact upon ou …
The Himalayan Sherpas, a human population of Tibetan descent, are highly adapted to life in the hypobaric hypoxia of high altitude. . …
Exercise Testing, Supplemental Oxygen, and Hypoxia.
Ward SA, Grocott MPW, Levett DZH. Ward SA, et al. Among authors: Levett DZH. Ann Am Thorac Soc. 2017 Jul;14(Supplement_1):S140-S148. doi: 10.1513/AnnalsATS.201701-043OT. Ann Am Thorac Soc. 2017. PMID: 28590162 Review.
CPET performance with supplemental O(2) in respiratory patients residing at high altitudes is also poorly studied. Finally, CPET has the potential to give physiological and clinical information about acute and chronic mountain sickness, high-altitude pulmonary edema …
CPET performance with supplemental O(2) in respiratory patients residing at high altitudes is also poorly studied. Finally, CPET has …
Caudwell Xtreme Everest: An Overview.
Grocott MP, Levett DZ, Martin DS, Wilson MH, Mackenney A, Dhillon S, Montgomery HE, Mythen MG, Mitchell K. Grocott MP, et al. Among authors: Levett DZ. Adv Exp Med Biol. 2016;903:427-37. doi: 10.1007/978-1-4899-7678-9_28. Adv Exp Med Biol. 2016. PMID: 27343112 Review.
A subgroup of climbing investigators ascended higher on Everest and obtained physiological measurements up to an altitude of 8400 m. ...
A subgroup of climbing investigators ascended higher on Everest and obtained physiological measurements up to an altitude of 8400 m. …
Sustained vasomotor control of skin microcirculation in Sherpas versus altitude-naive lowlanders: Experimental evidence from Xtreme Everest 2.
Davies T, Gilbert-Kawai E, Wythe S, Meale P, Mythen M, Levett D, Mitchell K, Grocott M, Clough G, Martin D; Xtreme Everest 2 Research Group. Davies T, et al. Among authors: Levett D. Exp Physiol. 2018 Nov;103(11):1494-1504. doi: 10.1113/EP087236. Epub 2018 Sep 12. Exp Physiol. 2018. PMID: 30182473
Sherpas, when exposed to hypobaric hypoxia at high altitude, demonstrated superior preservation of their peripheral microcirculatory perfusion, a greater oxygen unloading rate and sustained microvascular reactivity with enhanced vasomotion, when compared with altitude
Sherpas, when exposed to hypobaric hypoxia at high altitude, demonstrated superior preservation of their peripheral microcirculatory …
Metabolomic and lipidomic plasma profile changes in human participants ascending to Everest Base Camp.
O'Brien KA, Atkinson RA, Richardson L, Koulman A, Murray AJ, Harridge SDR, Martin DS, Levett DZH, Mitchell K, Mythen MG, Montgomery HE, Grocott MPW, Griffin JL, Edwards LM. O'Brien KA, et al. Among authors: Levett DZH. Sci Rep. 2019 Feb 19;9(1):2297. doi: 10.1038/s41598-019-38832-z. Sci Rep. 2019. PMID: 30783167 Free PMC article.
At high altitude oxygen delivery to the tissues is impaired leading to oxygen insufficiency (hypoxia). Acclimatisation requires adjustment to tissue metabolism, the details of which remain incompletely understood. ...Decreased isoleucine is of particular interest as a pote …
At high altitude oxygen delivery to the tissues is impaired leading to oxygen insufficiency (hypoxia). Acclimatisation requires adjus …
Genetic factors associated with exercise performance in atmospheric hypoxia.
Hennis PJ, O'Doherty AF, Levett DZ, Grocott MP, Montgomery HM. Hennis PJ, et al. Among authors: Levett DZ. Sports Med. 2015 May;45(5):745-61. doi: 10.1007/s40279-015-0309-8. Sports Med. 2015. PMID: 25682119 Free PMC article. Review.
In lowlanders who ascend to altitude, genetic factors may also contribute to the substantial interindividual variation in exercise performance noted at altitude. ...Support for the association between the ACE-I allele and improved high-altitude performance wa …
In lowlanders who ascend to altitude, genetic factors may also contribute to the substantial interindividual variation in exercise pe …
Changes in muscle proteomics in the course of the Caudwell Research Expedition to Mt. Everest.
Levett DZ, Viganò A, Capitanio D, Vasso M, De Palma S, Moriggi M, Martin DS, Murray AJ, Cerretelli P, Grocott MP, Gelfi C. Levett DZ, et al. Proteomics. 2015 Jan;15(1):160-71. doi: 10.1002/pmic.201400306. Epub 2014 Dec 4. Proteomics. 2015. PMID: 25370915
This study employed differential proteomic and immunoassay techniques to elucidate the biochemical mechanisms utilized by human muscle (vastus lateralis) in response to high altitude hypoxia exposure. Two groups of subjects, participating in a medical research expedition ( …
This study employed differential proteomic and immunoassay techniques to elucidate the biochemical mechanisms utilized by human muscle (vast …
Sublingual microcirculatory blood flow and vessel density in Sherpas at high altitude.
Gilbert-Kawai E, Coppel J, Court J, van der Kaaij J, Vercueil A, Feelisch M, Levett D, Mythen M, Grocott MP, Martin D; Xtreme Everest 2 Research Group. Gilbert-Kawai E, et al. Among authors: Levett D. J Appl Physiol (1985). 2017 Apr 1;122(4):1011-1018. doi: 10.1152/japplphysiol.00970.2016. Epub 2017 Jan 26. J Appl Physiol (1985). 2017. PMID: 28126908 Free PMC article.
Anecdotal reports suggest that Sherpa highlanders demonstrate extraordinary tolerance to hypoxia at high altitude, despite exhibiting lower arterial oxygen content than acclimatized lowlanders. ...These data suggest that Sherpas can maintain a significantly greater microci …
Anecdotal reports suggest that Sherpa highlanders demonstrate extraordinary tolerance to hypoxia at high altitude, despite exhibiting …
High altitude-related hypertensive crisis and acute kidney injury in an asymptomatic healthy individual.
Gilbert-Kawai E, Martin D, Grocott M, Levett D. Gilbert-Kawai E, et al. Among authors: Levett D. Extrem Physiol Med. 2016 Sep 14;5:10. doi: 10.1186/s13728-016-0051-3. eCollection 2016. Extrem Physiol Med. 2016. PMID: 27651893 Free PMC article.
BACKGROUND: High-altitude exposure causes a mild to moderate rise in systolic and diastolic blood pressure. This case report describes the first documented case of a hypertensive crisis at altitude, as well as the first report of the occurrence of acute kidney injur …
BACKGROUND: High-altitude exposure causes a mild to moderate rise in systolic and diastolic blood pressure. This case report describe …
Changes in acute pulmonary vascular responsiveness to hypoxia during a progressive ascent to high altitude (5300 m).
Luks AM, Levett D, Martin DS, Goss CH, Mitchell K, Fernandez BO, Feelisch M, Grocott MP, Swenson ER; Caudwell Xtreme Everest Investigators. Luks AM, et al. Among authors: Levett D. Exp Physiol. 2017 Jun 1;102(6):711-724. doi: 10.1113/EP086083. Epub 2017 May 21. Exp Physiol. 2017. PMID: 28390080 Free article.
Do the pulmonary vascular responses to hypoxia change during progressive exposure to high altitude and can alterations in these responses be related to changes in concentrations of circulating biomarkers that affect the pulmonary circulation? ...We sought to determine whet …
Do the pulmonary vascular responses to hypoxia change during progressive exposure to high altitude and can alterations in these respo …
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