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Copper staining: a five-minute protein stain for sodium dodecyl sulfate-polyacrylamide gels.
Lee C, Levin A, Branton D. Lee C, et al. Among authors: levin a. Anal Biochem. 1987 Nov 1;166(2):308-12. doi: 10.1016/0003-2697(87)90579-3. Anal Biochem. 1987. PMID: 2449094
We present a new method for visualizing proteins electrophoresed in sodium dodecyl sulfate-polyacrylamide gels. After electrophoresis, gels are incubated in CuCl2 to produce a negative image of colorless protein bands against a semiopaque background. ...
We present a new method for visualizing proteins electrophoresed in sodium dodecyl sulfate-polyacrylamide gels. After electrophoresis …
Abolition of actin-bundling by phosphorylation of human erythrocyte protein 4.9.
Husain-Chishti A, Levin A, Branton D. Husain-Chishti A, et al. Among authors: levin a. Nature. 1988 Aug 25;334(6184):718-21. doi: 10.1038/334718a0. Nature. 1988. PMID: 2842686
Protein 4.9, first identified as a component of the human erythrocyte membrane skeleton, binds to and bundles actin filaments. Protein 4.9 is a substrate for various kinases, including a cyclic AMP(cAMP)-dependent one, in vivo and in vitro. We show here that …
Protein 4.9, first identified as a component of the human erythrocyte membrane skeleton, binds to and bundles actin filaments. Protei …
Phosphorylation-induced conformational changes in a mitogen-activated protein kinase substrate. Implications for tyrosine hydroxylase activation.
Stultz CM, Levin AD, Edelman ER. Stultz CM, et al. Among authors: levin ad. J Biol Chem. 2002 Dec 6;277(49):47653-61. doi: 10.1074/jbc.M208755200. Epub 2002 Oct 1. J Biol Chem. 2002. PMID: 12361946
These results are consistent with a model of enzyme activation where phosphorylation of the MAP kinase substrate causes the N-terminal region to adopt a compact structure away from the active site. ...Therefore, they are expected to be applicable to a variety …
These results are consistent with a model of enzyme activation where phosphorylation of the MAP kinase substrate causes the N-termina …
Specific binding to intracellular proteins determines arterial transport properties for rapamycin and paclitaxel.
Levin AD, Vukmirovic N, Hwang CW, Edelman ER. Levin AD, et al. Proc Natl Acad Sci U S A. 2004 Jun 22;101(25):9463-7. doi: 10.1073/pnas.0400918101. Epub 2004 Jun 14. Proc Natl Acad Sci U S A. 2004. PMID: 15197278 Free PMC article.
Local and systemic drug competition in drug-eluting stent tissue deposition properties.
Levin AD, Jonas M, Hwang CW, Edelman ER. Levin AD, et al. J Control Release. 2005 Dec 5;109(1-3):236-43. doi: 10.1016/j.jconrel.2005.09.041. Epub 2005 Nov 11. J Control Release. 2005. PMID: 16289420
The commercially available DES drugs rapamycin and paclitaxel bind specifically to their respective therapeutic targets, FKBP12 and polymerized microtubules, while also associating in a more general manner with other tissue elements. ...
The commercially available DES drugs rapamycin and paclitaxel bind specifically to their respective therapeutic targets, FKBP12 and polymeri …
Diffusion-limited binding explains binary dose response for local arterial and tumour drug delivery.
Tzafriri AR, Levin AD, Edelman ER. Tzafriri AR, et al. Among authors: levin ad. Cell Prolif. 2009 Jun;42(3):348-63. doi: 10.1111/j.1365-2184.2009.00602.x. Epub 2009 Mar 31. Cell Prolif. 2009. PMID: 19438899 Free PMC article.
METHODS: We introduce a quantitative framework that balances dose, saturable binding and diffusion, and measured the specific binding parameters of drugs to target tissues. RESULTS: Model reduction techniques augmented by numerical simulations revealed that impact of satur …
METHODS: We introduce a quantitative framework that balances dose, saturable binding and diffusion, and measured the specific binding …
Thrombosis modulates arterial drug distribution for drug-eluting stents.
Hwang CW, Levin AD, Jonas M, Li PH, Edelman ER. Hwang CW, et al. Among authors: levin ad. Circulation. 2005 Apr 5;111(13):1619-26. doi: 10.1161/01.CIR.0000160363.30639.37. Epub 2005 Mar 28. Circulation. 2005. PMID: 15795325
Computational models predict that the potential of thrombus to absorb, retain, and release drug or to act as a barrier to drug delivery depends on clot geometry and strut position in clot relative to the vessel wall. ...Model assumptions were confirmed and predictions were …
Computational models predict that the potential of thrombus to absorb, retain, and release drug or to act as a barrier to drug delive …
Management of Advanced Chronic Kidney Disease During the COVID-19 Pandemic: Suggestions From the Canadian Society of Nephrology COVID-19 Rapid Response Team.
White CA, Kappel JE, Levin A, Moran SM, Pandeya S, Thanabalasingam SJ; CSN COVID-19 Rapid Response Team. White CA, et al. Among authors: levin a. Can J Kidney Health Dis. 2020 Jul 19;7:2054358120939354. doi: 10.1177/2054358120939354. eCollection 2020. Can J Kidney Health Dis. 2020. PMID: 32733692 Free PMC article.
"Soup cans, brooms, and Zoom:" Rapid conversion of a cancer survivorship program to telehealth during COVID-19.
Jhaveri K, Cohen JA, Barulich M, Levin AO, Goyal N, Loveday T, Chesney MA, Shumay DM. Jhaveri K, et al. Among authors: levin ao. Psychooncology. 2020 Jul 16. doi: 10.1002/pon.5473. Online ahead of print. Psychooncology. 2020. PMID: 32672845 No abstract available.
Biomolecular condensates undergo a generic shear-mediated liquid-to-solid transition.
Shen Y, Ruggeri FS, Vigolo D, Kamada A, Qamar S, Levin A, Iserman C, Alberti S, George-Hyslop PS, Knowles TPJ. Shen Y, et al. Among authors: levin a. Nat Nanotechnol. 2020 Jul 13. doi: 10.1038/s41565-020-0731-4. Online ahead of print. Nat Nanotechnol. 2020. PMID: 32661370
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