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p53, the cellular gatekeeper for growth and division.
Levine AJ. Levine AJ. Cell. 1997 Feb 7;88(3):323-31. doi: 10.1016/s0092-8674(00)81871-1. Cell. 1997. PMID: 9039259 Review. No abstract available.
Involvement of tumor suppressors PTEN and p53 in the formation of multiple subtypes of liposarcoma.
Puzio-Kuter AM, Laddha SV, Castillo-Martin M, Sun Y, Cordon-Cardo C, Chan CS, Levine AJ. Puzio-Kuter AM, et al. Among authors: levine aj. Cell Death Differ. 2015 Nov;22(11):1785-91. doi: 10.1038/cdd.2015.27. Epub 2015 Mar 27. Cell Death Differ. 2015. PMID: 25822339 Free PMC article.
The bromodomain and extra-terminal inhibitor CPI203 enhances the antiproliferative effects of rapamycin on human neuroendocrine tumors.
Wong C, Laddha SV, Tang L, Vosburgh E, Levine AJ, Normant E, Sandy P, Harris CR, Chan CS, Xu EY. Wong C, et al. Among authors: levine aj. Cell Death Dis. 2014 Oct 9;5(10):e1450. doi: 10.1038/cddis.2014.396. Cell Death Dis. 2014. PMID: 25299775 Free PMC article.
Single-nucleotide polymorphisms in the p53 pathway.
Harris SL, Gil G, Hu W, Robins H, Bond E, Hirshfield K, Feng Z, Yu X, Teresky AK, Bond G, Levine AJ. Harris SL, et al. Among authors: levine aj. Cold Spring Harb Symp Quant Biol. 2005;70:111-9. doi: 10.1101/sqb.2005.70.024. Cold Spring Harb Symp Quant Biol. 2005. PMID: 16869744
A single nucleotide polymorphism in the p53 pathway interacts with gender, environmental stresses and tumor genetics to influence cancer in humans.
Bond GL, Levine AJ. Bond GL, et al. Among authors: levine aj. Oncogene. 2007 Feb 26;26(9):1317-23. doi: 10.1038/sj.onc.1210199. Oncogene. 2007. PMID: 17322917 Review.
The p53 tetramer shows an induced-fit interaction of the C-terminal domain with the DNA-binding domain.
D'Abramo M, BeŇ°ker N, Desideri A, Levine AJ, Melino G, Chillemi G. D'Abramo M, et al. Among authors: levine aj. Oncogene. 2016 Jun 23;35(25):3272-81. doi: 10.1038/onc.2015.388. Epub 2015 Oct 19. Oncogene. 2016. PMID: 26477317 Free PMC article.
p53 tumor suppressor protein regulates the levels of huntingtin gene expression.
Feng Z, Jin S, Zupnick A, Hoh J, de Stanchina E, Lowe S, Prives C, Levine AJ. Feng Z, et al. Among authors: levine aj. Oncogene. 2006 Jan 5;25(1):1-7. doi: 10.1038/sj.onc.1209021. Oncogene. 2006. PMID: 16278683
Physical and functional interaction between p53 mutants and different isoforms of p73.
Strano S, Munarriz E, Rossi M, Cristofanelli B, Shaul Y, Castagnoli L, Levine AJ, Sacchi A, Cesareni G, Oren M, Blandino G. Strano S, et al. Among authors: levine aj. J Biol Chem. 2000 Sep 22;275(38):29503-12. doi: 10.1074/jbc.M003360200. J Biol Chem. 2000. PMID: 10884390
Two critical hydrophobic amino acids in the N-terminal domain of the p53 protein are required for the gain of function phenotypes of human p53 mutants.
Lin J, Teresky AK, Levine AJ. Lin J, et al. Among authors: levine aj. Oncogene. 1995 Jun 15;10(12):2387-90. Oncogene. 1995. PMID: 7784087
The P53 pathway: what questions remain to be explored?
Levine AJ, Hu W, Feng Z. Levine AJ, et al. Cell Death Differ. 2006 Jun;13(6):1027-36. doi: 10.1038/sj.cdd.4401910. Cell Death Differ. 2006. PMID: 16557269 Review.
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