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Neurobeachin, a regulator of synaptic protein targeting, is associated with body fat mass and feeding behavior in mice and body-mass index in humans.
Olszewski PK, Rozman J, Jacobsson JA, Rathkolb B, Strömberg S, Hans W, Klockars A, Alsiö J, Risérus U, Becker L, Hölter SM, Elvert R, Ehrhardt N, Gailus-Durner V, Fuchs H, Fredriksson R, Wolf E, Klopstock T, Wurst W, Levine AS, Marcus C, de Angelis MH, Klingenspor M, Schiöth HB, Kilimann MW. Olszewski PK, et al. Among authors: levine as. PLoS Genet. 2012;8(3):e1002568. doi: 10.1371/journal.pgen.1002568. Epub 2012 Mar 15. PLoS Genet. 2012. PMID: 22438821 Free PMC article.
Fto immunoreactivity is widespread in the rodent brain and abundant in feeding-related sites, but the number of Fto-positive cells is not affected by changes in energy balance.
Olszewski PK, Radomska KJ, Ghimire K, Klockars A, Ingman C, Olszewska AM, Fredriksson R, Levine AS, Schiöth HB. Olszewski PK, et al. Among authors: levine as. Physiol Behav. 2011 May 3;103(2):248-53. doi: 10.1016/j.physbeh.2011.01.022. Epub 2011 Feb 2. Physiol Behav. 2011. PMID: 21295049
The obesity gene, TMEM18, is of ancient origin, found in majority of neuronal cells in all major brain regions and associated with obesity in severely obese children.
Almén MS, Jacobsson JA, Shaik JH, Olszewski PK, Cedernaes J, Alsiö J, Sreedharan S, Levine AS, Fredriksson R, Marcus C, Schiöth HB. Almén MS, et al. Among authors: levine as. BMC Med Genet. 2010 Apr 9;11:58. doi: 10.1186/1471-2350-11-58. BMC Med Genet. 2010. PMID: 20380707 Free PMC article.
The contribution of brain reward circuits to the obesity epidemic.
Stice E, Figlewicz DP, Gosnell BA, Levine AS, Pratt WE. Stice E, et al. Among authors: levine as. Neurosci Biobehav Rev. 2013 Nov;37(9 Pt A):2047-58. doi: 10.1016/j.neubiorev.2012.12.001. Epub 2012 Dec 10. Neurosci Biobehav Rev. 2013. PMID: 23237885 Free PMC article. Review.
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