Levine RL - Search Results

1

Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6.

Zhang Q, Zhao K, Shen Q, Han Y, Gu Y, Li X, Zhao D, Liu Y, Wang C, Zhang X, Su X, Liu J, Ge W, Levine RL, Li N, Cao X. Zhang Q, et al. Among authors: levine rl. Nature. 2015 Sep 17;525(7569):389-393. doi: 10.1038/nature15252. Epub 2015 Aug 19. Nature. 2015. PMID: 26287468 Free PMC article.

2

IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype.

Turcan S, Rohle D, Goenka A, Walsh LA, Fang F, Yilmaz E, Campos C, Fabius AW, Lu C, Ward PS, Thompson CB, Kaufman A, Guryanova O, Levine R, Heguy A, Viale A, Morris LG, Huse JT, Mellinghoff IK, Chan TA. Turcan S, et al. Nature. 2012 Feb 15;483(7390):479-83. doi: 10.1038/nature10866. Nature. 2012. PMID: 22343889 Free PMC article.

3

IDH mutation impairs histone demethylation and results in a block to cell differentiation.

Lu C, Ward PS, Kapoor GS, Rohle D, Turcan S, Abdel-Wahab O, Edwards CR, Khanin R, Figueroa ME, Melnick A, Wellen KE, O'Rourke DM, Berger SL, Chan TA, Levine RL, Mellinghoff IK, Thompson CB. Lu C, et al. Among authors: levine rl. Nature. 2012 Feb 15;483(7390):474-8. doi: 10.1038/nature10860. Nature. 2012. PMID: 22343901 Free PMC article.

4

Heterodimeric JAK-STAT activation as a mechanism of persistence to JAK2 inhibitor therapy.

Koppikar P, Bhagwat N, Kilpivaara O, Manshouri T, Adli M, Hricik T, Liu F, Saunders LM, Mullally A, Abdel-Wahab O, Leung L, Weinstein A, Marubayashi S, Goel A, Gönen M, Estrov Z, Ebert BL, Chiosis G, Nimer SD, Bernstein BE, Verstovsek S, Levine RL. Koppikar P, et al. Among authors: levine rl. Nature. 2012 Sep 6;489(7414):155-9. doi: 10.1038/nature11303. Nature. 2012. PMID: 22820254 Free PMC article.

5

The role of mutations in epigenetic regulators in myeloid malignancies.

Shih AH, Abdel-Wahab O, Patel JP, Levine RL. Shih AH, et al. Among authors: levine rl. Nat Rev Cancer. 2012 Sep;12(9):599-612. doi: 10.1038/nrc3343. Epub 2012 Aug 17. Nat Rev Cancer. 2012. PMID: 22898539 Review.

6

Early-stage epigenetic modification during somatic cell reprogramming by Parp1 and Tet2.

Doege CA, Inoue K, Yamashita T, Rhee DB, Travis S, Fujita R, Guarnieri P, Bhagat G, Vanti WB, Shih A, Levine RL, Nik S, Chen EI, Abeliovich A. Doege CA, et al. Among authors: levine rl. Nature. 2012 Aug 30;488(7413):652-5. doi: 10.1038/nature11333. Nature. 2012. PMID: 22902501 Free PMC article.

7

Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis.

Busque L, Patel JP, Figueroa ME, Vasanthakumar A, Provost S, Hamilou Z, Mollica L, Li J, Viale A, Heguy A, Hassimi M, Socci N, Bhatt PK, Gonen M, Mason CE, Melnick A, Godley LA, Brennan CW, Abdel-Wahab O, Levine RL. Busque L, et al. Among authors: levine rl. Nat Genet. 2012 Nov;44(11):1179-81. doi: 10.1038/ng.2413. Epub 2012 Sep 23. Nat Genet. 2012. PMID: 23001125 Free PMC article.

8

Role of TET2 and ASXL1 mutations in the pathogenesis of myeloproliferative neoplasms.

Abdel-Wahab O, Tefferi A, Levine RL. Abdel-Wahab O, et al. Among authors: levine rl. Hematol Oncol Clin North Am. 2012 Oct;26(5):1053-64. doi: 10.1016/j.hoc.2012.07.006. Epub 2012 Aug 21. Hematol Oncol Clin North Am. 2012. PMID: 23009937 Free PMC article. Review.

9

Cholesterol efflux in megakaryocyte progenitors suppresses platelet production and thrombocytosis.

Murphy AJ, Bijl N, Yvan-Charvet L, Welch CB, Bhagwat N, Reheman A, Wang Y, Shaw JA, Levine RL, Ni H, Tall AR, Wang N. Murphy AJ, et al. Among authors: levine rl. Nat Med. 2013 May;19(5):586-94. doi: 10.1038/nm.3150. Epub 2013 Apr 14. Nat Med. 2013. PMID: 23584088 Free PMC article.

10

Mining the epigenetic landscape in ALL.

Lafave LM, Levine RL. Lafave LM, et al. Among authors: levine rl. Nat Genet. 2013 Nov;45(11):1269-70. doi: 10.1038/ng.2808. Nat Genet. 2013. PMID: 24165727

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