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Pre-existing anti-PEG antibodies are associated with severe immediate allergic reactions to pegnivacogin, a PEGylated aptamer.
Povsic TJ, Lawrence MG, Lincoff AM, Mehran R, Rusconi CP, Zelenkofske SL, Huang Z, Sailstad J, Armstrong PW, Steg PG, Bode C, Becker RC, Alexander JH, Adkinson NF, Levinson AI; REGULATE-PCI Investigators. Povsic TJ, et al. Among authors: levinson ai. J Allergy Clin Immunol. 2016 Dec;138(6):1712-1715. doi: 10.1016/j.jaci.2016.04.058. Epub 2016 Jul 14. J Allergy Clin Immunol. 2016. PMID: 27522158 No abstract available.
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