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spr-2, a suppressor of the egg-laying defect caused by loss of sel-12 presenilin in Caenorhabditis elegans, is a member of the SET protein subfamily.
Wen C, Levitan D, Li X, Greenwald I. Wen C, et al. Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14524-9. doi: 10.1073/pnas.011446498. Proc Natl Acad Sci U S A. 2000. PMID: 11114162 Free PMC article.
Assessment of normal and mutant human presenilin function in Caenorhabditis elegans.
Levitan D, Doyle TG, Brousseau D, Lee MK, Thinakaran G, Slunt HH, Sisodia SS, Greenwald I. Levitan D, et al. Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14940-4. doi: 10.1073/pnas.93.25.14940. Proc Natl Acad Sci U S A. 1996. PMID: 8962160 Free PMC article.
Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing.
Yu G, Nishimura M, Arawaka S, Levitan D, Zhang L, Tandon A, Song YQ, Rogaeva E, Chen F, Kawarai T, Supala A, Levesque L, Yu H, Yang DS, Holmes E, Milman P, Liang Y, Zhang DM, Xu DH, Sato C, Rogaev E, Smith M, Janus C, Zhang Y, Aebersold R, Farrer LS, Sorbi S, Bruni A, Fraser P, St George-Hyslop P. Yu G, et al. Nature. 2000 Sep 7;407(6800):48-54. doi: 10.1038/35024009. Nature. 2000. PMID: 10993067
Mutation of the conserved N-terminal cysteine (Cys92) of human presenilin 1 causes increased A beta42 secretion in mammalian cells but impaired Notch/lin-12 signalling in C. elegans.
Zhang DM, Levitan D, Yu G, Nishimura M, Chen F, Tandon A, Kawarai T, Arawaka S, Supala A, Song YQ, Rogaeva E, Liang Y, Holmes E, Milman P, Sato C, Zhang L, St George-Hyslop P. Zhang DM, et al. Neuroreport. 2000 Sep 28;11(14):3227-30. doi: 10.1097/00001756-200009280-00035. Neuroreport. 2000. PMID: 11043553
par-2, a gene required for blastomere asymmetry in Caenorhabditis elegans, encodes zinc-finger and ATP-binding motifs.
Levitan DJ, Boyd L, Mello CC, Kemphues KJ, Stinchcomb DT. Levitan DJ, et al. Proc Natl Acad Sci U S A. 1994 Jun 21;91(13):6108-12. doi: 10.1073/pnas.91.13.6108. Proc Natl Acad Sci U S A. 1994. PMID: 8016123 Free PMC article.
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