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Year Number of Results
2002 4
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19 results

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Page 1
The four and a half LIM-only protein 2 (FHL2) activates transforming growth factor beta (TGF-beta) signaling by regulating ubiquitination of the E3 ligase Arkadia.
Xia T, Lévy L, Levillayer F, Jia B, Li G, Neuveut C, Buendia MA, Lan K, Wei Y. Xia T, et al. Among authors: levy l. J Biol Chem. 2013 Jan 18;288(3):1785-94. doi: 10.1074/jbc.M112.439760. Epub 2012 Dec 4. J Biol Chem. 2013. PMID: 23212909 Free PMC article.
Knockdown of FHL2 by RNA interference decreases Arkadia level and restricts the amplitude of Arkadia-induced TGF-beta target gene responses. ...Our study uncovers a novel regulatory mechanism of Arkadia by ubiquitination and identifies FHL2 as i …
Knockdown of FHL2 by RNA interference decreases Arkadia level and restricts the amplitude of Arkadia-induced TGF-bet …
Arkadia regulates tumor metastasis by modulation of the TGF-beta pathway.
Briones-Orta MA, Levy L, Madsen CD, Das D, Erker Y, Sahai E, Hill CS. Briones-Orta MA, et al. Among authors: levy l. Cancer Res. 2013 Mar 15;73(6):1800-10. doi: 10.1158/0008-5472.CAN-12-1916. Epub 2013 Mar 6. Cancer Res. 2013. PMID: 23467611 Free PMC article.
TGF-beta can act as a tumor suppressor at early stages of cancer progression and as a tumor promoter at later stages. The E3 ubiquitin ligase Arkadia (RNF111) is a critical component of the TGF-beta signaling pathway, being required for a subset …
TGF-beta can act as a tumor suppressor at early stages of cancer progression and as a tumor promoter at later stages. The E3 u …
The UAS thioredoxin-like domain of UBXN7 regulates E3 ubiquitin ligase activity of RNF111/Arkadia.
Amhaz S, Boëda B, Chouchène M, Colasse S, Dingli F, Loew D, Henri J, Prunier C, Levy L. Amhaz S, et al. Among authors: levy l. BMC Biol. 2023 Apr 7;21(1):73. doi: 10.1186/s12915-023-01576-4. BMC Biol. 2023. PMID: 37024974 Free PMC article.
BACKGROUND: E3 ubiquitin ligases play critical roles in regulating cellular signaling pathways by inducing ubiquitylation of key components. RNF111/Arkadia is a RING E3 ubiquitin ligase that activates TGF-beta signaling by inducing ubiquitylation and proteaso …
BACKGROUND: E3 ubiquitin ligases play critical roles in regulating cellular signaling pathways by inducing ubiquitylation of key components. …
Arkadia, a novel SUMO-targeted ubiquitin ligase involved in PML degradation.
Erker Y, Neyret-Kahn H, Seeler JS, Dejean A, Atfi A, Levy L. Erker Y, et al. Among authors: levy l. Mol Cell Biol. 2013 Jun;33(11):2163-77. doi: 10.1128/MCB.01019-12. Epub 2013 Mar 25. Mol Cell Biol. 2013. PMID: 23530056 Free PMC article.
Arkadia is a RING domain E3 ubiquitin ligase that activates the transforming growth factor beta (TGF-beta) pathway by inducing degradation of the inhibitor SnoN/Ski. ...While the SIMs of Arkadia are not essential for SnoN/Sk …
Arkadia is a RING domain E3 ubiquitin ligase that activates the transforming growth factor beta (TGF …
Quantitative Ubiquitylome Analysis Reveals the Specificity of RNF111/Arkadia E3 Ubiquitin Ligase for its Degradative Substrates SKI and SKIL/SnoN in TGF-beta Signaling Pathway.
Laigle V, Dingli F, Amhaz S, Perron T, Chouchène M, Colasse S, Petit I, Poullet P, Loew D, Prunier C, Levy L. Laigle V, et al. Among authors: levy l. Mol Cell Proteomics. 2021;20:100173. doi: 10.1016/j.mcpro.2021.100173. Epub 2021 Nov 3. Mol Cell Proteomics. 2021. PMID: 34740826 Free PMC article.
RNF111/Arkadia is an E3 ubiquitin ligase that activates the transforming growth factor-beta (TGF-beta) pathway by degrading transcriptional repressors SKIL/SnoN and SKI. Truncations of the RING C-terminal domain of RNF111 that abol …
RNF111/Arkadia is an E3 ubiquitin ligase that activates the transforming growth factor-beta (TGF- …
Arkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation.
Levy L, Howell M, Das D, Harkin S, Episkopou V, Hill CS. Levy L, et al. Mol Cell Biol. 2007 Sep;27(17):6068-83. doi: 10.1128/MCB.00664-07. Epub 2007 Jun 25. Mol Cell Biol. 2007. PMID: 17591695 Free PMC article.
E3 ubiquitin ligases play important roles in regulating transforming growth factor beta (TGF-beta)/Smad signaling. Screening of an E3 ubiquitin ligase small interfering RNA library, using TGF-beta induction of a Smad3/Smad4- …
E3 ubiquitin ligases play important roles in regulating transforming growth factor beta (TGF-beta) …
Alterations in components of the TGF-beta superfamily signaling pathways in human cancer.
Levy L, Hill CS. Levy L, et al. Cytokine Growth Factor Rev. 2006 Feb-Apr;17(1-2):41-58. doi: 10.1016/j.cytogfr.2005.09.009. Epub 2005 Nov 23. Cytokine Growth Factor Rev. 2006. PMID: 16310402 Review.
Signaling by transforming growth factor-beta (TGF-beta) superfamily ligands to the nucleus is mediated by type I and type II receptors and the intracellular signal transducers, the Smads. ...The evidence suggests that not all alterations …
Signaling by transforming growth factor-beta (TGF-beta) superfamily ligands to the nucleus is medi …
Acetylation of beta-catenin by p300 regulates beta-catenin-Tcf4 interaction.
Lévy L, Wei Y, Labalette C, Wu Y, Renard CA, Buendia MA, Neuveut C. Lévy L, et al. Mol Cell Biol. 2004 Apr;24(8):3404-14. doi: 10.1128/MCB.24.8.3404-3414.2004. Mol Cell Biol. 2004. PMID: 15060161 Free PMC article.
We demonstrated that the acetyltransferase activity of p300 was required for efficient activation of transcription mediated by beta-catenin/Tcf4 and that the cooperation between p300 and beta-catenin was severely reduced by the K345R mutation, implying …
We demonstrated that the acetyltransferase activity of p300 was required for efficient activation of transcription mediated by beta- …
Cell-to-cell spread of vaccinia virus is promoted by TGF-beta-independent Smad4 signalling.
Gowripalan A, Abbott CR, McKenzie C, Chan WS, Karupiah G, Levy L, Newsome TP. Gowripalan A, et al. Among authors: levy l. Cell Microbiol. 2020 Aug;22(8):e13206. doi: 10.1111/cmi.13206. Epub 2020 Apr 28. Cell Microbiol. 2020. PMID: 32237038
VACV induction of TGF-beta/Smad-responsive gene expression does not require the TGF-beta ligand or type I and type II TGF-beta receptors, suggesting a novel, non-canonical Smad signalling pathway. Additionally, the spread of ectromelia vi …
VACV induction of TGF-beta/Smad-responsive gene expression does not require the TGF-beta ligand or type I and ty …
New targets of beta-catenin signaling in the liver are involved in the glutamine metabolism.
Cadoret A, Ovejero C, Terris B, Souil E, Lévy L, Lamers WH, Kitajewski J, Kahn A, Perret C. Cadoret A, et al. Among authors: levy l. Oncogene. 2002 Nov 28;21(54):8293-301. doi: 10.1038/sj.onc.1206118. Oncogene. 2002. PMID: 12447692
Inappropriate activation of the Wnt/beta-catenin signaling has been implicated in the development of hepatocellular carcinoma (HCC), but exactly how beta-catenin works remains to be elucidated. ...Together, our results indicate that GS is a target of t …
Inappropriate activation of the Wnt/beta-catenin signaling has been implicated in the development of hepatocellular carcinoma …
19 results