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Year Number of Results
2001 1
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66 results

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Page 1
Loss of PILRA promotes microglial immunometabolism to reduce amyloid pathology in cell and mouse models of Alzheimer's disease.
Weerakkody TN, Sabelström H, Andrews SV, Chadarevian JP, Chin MY, Tatarakis D, Propson NE, Kim DJ, Theolis R, Parico GCG, Misker H, Kung JE, Bandyopadhyay A, Robles Colmenares Y, Jackson TN, Qerqez AN, Balasundar S, Davis SS, Ha C, Ghosh R, Ravi R, Rana A, Germain K, Tao A, Xiong K, Braun D, Raju K, Huang KC, Zhan L, Guo JL, Safari Yazd H, Sarrafha L, Capocchi JK, Hasselmann J, Chadarevian AL, Tu C, Mansour K, Eskandari-Sedighi G, Tesi N, van der Lee S, Hulsman M, Oshegov G, Pijnenburg Y, Calvert M, Holstege H, Suh JH, Di Paolo G, Davtyan H, Lewcock JW, Blurton-Jones M, Monroe KM. Weerakkody TN, et al. Among authors: lewcock jw. Sci Transl Med. 2025 Dec 3;17(827):eadw7428. doi: 10.1126/scitranslmed.adw7428. Epub 2025 Dec 3. Sci Transl Med. 2025. PMID: 41337541
Early intervention anti-Aβ immunotherapy attenuates microglial activation without inducing exhaustion at residual plaques.
de Weerd L, Hummel S, Müller SA, Paris I, Sandmann T, Eichholtz M, Gröger R, Englert AL, Wagner S, Ha C, Davis SS, Warkins V, Xia D, Nuscher B, Berghofer A, Reich M, Feiten AF, Schlepckow K, Willem M, Lichtenthaler SF, Lewcock JW, Monroe KM, Brendel M, Haass C. de Weerd L, et al. Among authors: lewcock jw. Mol Neurodegener. 2025 Aug 20;20(1):92. doi: 10.1186/s13024-025-00878-1. Mol Neurodegener. 2025. PMID: 40830489 Free PMC article.
Investigational eIF2B activator DNL343 modulates the integrated stress response in preclinical models of TDP-43 pathology and individuals with ALS in a randomized clinical trial.
Flores BN, Yu SB, Cohen IV, Fanok MH, Luan W, Maciuca RD, Sun LD, Tsai RM, Vissers M, Smits L, Bunte TM, Bakardjiev A, Balasundar S, Calvert MEK, Chin MY, Dobbins SK, Dowdle WE, Fang M, Heuberger JAAC, Ha CL, Huang F, Miyamoto T, Osipov M, Madrid San Martin L, Saund K, Tatarakis D, Vu AQ, Xiong C, Yeo GW, Groeneveld GJ, van den Berg LH, Dhuria S, Estrada AA, Jennings D, Sandmann T, Ho C, Scearce-Levie K, Yulyaningsih E, Walker AK, Di Paolo G, Kane LA, Troyer MD, Lewcock JW. Flores BN, et al. Among authors: lewcock jw. Nat Commun. 2025 Aug 18;16(1):7690. doi: 10.1038/s41467-025-63031-y. Nat Commun. 2025. PMID: 40825784 Free PMC article. Clinical Trial.
Transferrin receptor-mediated transport at the blood-brain barrier is elevated during early development and maintained across aging and in an Alzheimer's mouse model.
Torres VO, Pizzo ME, Chan D, Dugas JC, Huynh D, Joy D, Liang EK, Sarrafha L, Becerra I, Chau R, Chew KS, Chow J, Discenza CB, Earr TK, Furaso L, Khoury N, Lechtenberg KJ, Leung AW, Nguyen HN, Ojo ES, Roche E, Simon MJ, Solanoy H, Tong M, Tong RK, Henne K, Lewcock JW, Watts RJ, Calvert ME, Thorne RG, Zuchero YJY. Torres VO, et al. Among authors: lewcock jw. J Cereb Blood Flow Metab. 2025 Aug 16:271678X251361997. doi: 10.1177/0271678X251361997. Online ahead of print. J Cereb Blood Flow Metab. 2025. PMID: 40817783 Free PMC article.
Transferrin receptor-targeted anti-amyloid antibody enhances brain delivery and mitigates ARIA.
Pizzo ME, Plowey ED, Khoury N, Kwan W, Abettan J, DeVos SL, Discenza CB, Earr T, Joy D, Lye-Barthel M, Roche E, Chan D, Dugas JC, Gadkar K, Hamann S, Meisner R, Sebalusky J, Silva Amaral AC, Becerra I, Chau R, Chow J, Clemens AJ, Dennis MS, Duque J, Fusaro L, Getz JA, Kariolis MS, Kim DJ, Lechtenberg KJ, Leung AW, Moshkforoush A, Nguyen HN, Ojo ES, Thomsen ER, Torres VO, Sanchez PE, Shan L, Silverman AP, Sweeney ZK, Solanoy H, Tong R, Calvert ME, Watts RJ, Thorne RG, Weinreb PH, Walsh DM, Lewcock JW, Bussiere T, Zuchero YJY. Pizzo ME, et al. Among authors: lewcock jw. Science. 2025 Aug 7;389(6760):eads3204. doi: 10.1126/science.ads3204. Epub 2025 Aug 7. Science. 2025. PMID: 40773560
LRRK2 kinase activity regulates Parkinson's disease-relevant lipids at the lysosome.
Maloney MT, Wang X, Ghosh R, Andrews SV, Maciuca R, Masoud ST, Agam M, Caprioli RM, Astarita G, Bondar VV, Chen J, Chiu CL, Davis SS, Ho AC, Nguyen HN, Propson NE, Reyzer ML, Davis OB, Deen MC, Zhu S, Di Paolo G, Vocadlo DJ, Estrada AA, de Vicente J, Lewcock JW, Arguello A, Suh JH, Huntwork-Rodriguez S, Henry AG. Maloney MT, et al. Among authors: lewcock jw. Mol Neurodegener. 2025 Aug 6;20(1):89. doi: 10.1186/s13024-025-00880-7. Mol Neurodegener. 2025. PMID: 40770658 Free PMC article.
Dual targeting of transferrin receptor and CD98hc enhances brain exposure of large molecules.
Wells RC, Akkapeddi P, Chan D, Joy D, Moshkforoush A, Chau R, Chow J, Cherf GM, Chien EYT, Clemens A, Pizzo ME, Qerqez AN, Tran T, Becerra I, Dugas JC, Duque J, Earr TK, Huynh D, Kim DJ, Wing-Sze Leung A, Liang E, Nguyen HN, Robles-Colmenares Y, Kane H, Roche E, Sacayon P, Xa K, Solanoy H, Dennis MS, Lewcock JW, Watts RJ, Kariolis MS, Thorne RG, Koth CM, Calvert MEK, Yu Zuchero YJ, Chew KS. Wells RC, et al. Among authors: lewcock jw. Cell Rep. 2025 Aug 26;44(8):116038. doi: 10.1016/j.celrep.2025.116038. Epub 2025 Jul 22. Cell Rep. 2025. PMID: 40705600 Free article.
Fc-engineered large molecules targeting blood-brain barrier transferrin receptor and CD98hc have distinct central nervous system and peripheral biodistribution.
Khoury N, Pizzo ME, Discenza CB, Joy D, Tatarakis D, Todorov MI, Negwer M, Ha C, De Melo GL, Sarrafha L, Simon MJ, Chan D, Chau R, Chew KS, Chow J, Clemens A, Robles-Colmenares Y, Dugas JC, Duque J, Kaltenecker D, Kane H, Leung A, Lozano E, Moshkforoush A, Roche E, Sandmann T, Tong M, Xa K, Zhou Y, Lewcock JW, Ertürk A, Thorne RG, Calvert MEK, Yu Zuchero YJ. Khoury N, et al. Among authors: lewcock jw. Nat Commun. 2025 Feb 20;16(1):1822. doi: 10.1038/s41467-025-57108-x. Nat Commun. 2025. PMID: 39979268 Free PMC article.
66 results