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Metabolism of 2,5-bis(trifluoromethyl)-7-benzyloxy-4-trifluoromethylcoumarin by human hepatic CYP isoforms: evidence for selectivity towards CYP3A4.
Renwick AB, Lewis DF, Fulford S, Surry D, Williams B, Worboys PD, Cai X, Wang RW, Price RJ, Lake BG, Evans DC. Renwick AB, et al. Xenobiotica. 2001 Apr;31(4):187-204. doi: 10.1080/00498250110043526. Xenobiotica. 2001. PMID: 11465405
Molecular modelling of CYP2B6, the human CYP2B isoform, by homology with the substrate-bound CYP102 crystal structure: evaluation of CYP2B6 substrate characteristics, the cytochrome b5 binding site and comparisons with CYP2B1 and CYP2B4.
Lewis DF, Lake BG, Dickins M, Eddershaw PJ, Tarbit MH, Goldfarb PS. Lewis DF, et al. Xenobiotica. 1999 Apr;29(4):361-93. doi: 10.1080/004982599238560. Xenobiotica. 1999. PMID: 10375007
Molecular modelling of human CYP2C subfamily enzymes CYP2C9 and CYP2C19: rationalization of substrate specificity and site-directed mutagenesis experiments in the CYP2C subfamily.
Lewis DF, Dickins M, Weaver RJ, Eddershaw PJ, Goldfarb PS, Tarbit MH. Lewis DF, et al. Xenobiotica. 1998 Mar;28(3):235-68. doi: 10.1080/004982598239542. Xenobiotica. 1998. PMID: 9574814
In vitro metabolism of dexamethasone (DEX) in human liver and kidney: the involvement of CYP3A4 and CYP17 (17,20 LYASE) and molecular modelling studies.
Tomlinson ES, Lewis DF, Maggs JL, Kroemer HK, Park BK, Back DJ. Tomlinson ES, et al. Biochem Pharmacol. 1997 Sep 1;54(5):605-11. doi: 10.1016/s0006-2952(97)00166-4. Biochem Pharmacol. 1997. PMID: 9337077
Cytochromes P450, oxygen, and evolution.
Lewis DF, Sheridan G. Lewis DF, et al. ScientificWorldJournal. 2001 Apr 4;1:151-67. doi: 10.1100/tsw.2001.22. ScientificWorldJournal. 2001. PMID: 12805700 Free PMC article. Review.
The metabolism of tamoxifen by human cytochromes P450 is rationalized by molecular modelling of the enzyme-substrate interactions: potential importance to its proposed anti-carcinogenic/carcinogenic actions.
Wiseman H, Lewis DF. Wiseman H, et al. Carcinogenesis. 1996 Jun;17(6):1357-60. doi: 10.1093/carcin/17.6.1357. Carcinogenesis. 1996. PMID: 8681455
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