Lewis H - Search Results

1

Secretase inhibitors for Alzheimer's disease: challenges of a promiscuous protease.

Pollack SJ, Lewis H. Pollack SJ, et al. Among authors: lewis h. Curr Opin Investig Drugs. 2005 Jan;6(1):35-47. Curr Opin Investig Drugs. 2005. PMID: 15675602 Review.

2

Catalytic site-directed gamma-secretase complex inhibitors do not discriminate pharmacologically between Notch S3 and beta-APP cleavages.

Lewis HD, Pérez Revuelta BI, Nadin A, Neduvelil JG, Harrison T, Pollack SJ, Shearman MS. Lewis HD, et al. Biochemistry. 2003 Jun 24;42(24):7580-6. doi: 10.1021/bi034310g. Biochemistry. 2003. PMID: 12809514

3

3-Substituted gem-cyclohexane sulfone based gamma-secretase inhibitors for Alzheimer's disease: conformational analysis and biological activity.

Jelley RA, Elliott J, Gibson KR, Harrison T, Beher D, Clarke EE, Lewis HD, Shearman M, Wrigley JD. Jelley RA, et al. Bioorg Med Chem Lett. 2006 Jul 15;16(14):3839-42. doi: 10.1016/j.bmcl.2006.04.019. Epub 2006 May 6. Bioorg Med Chem Lett. 2006. PMID: 16682202

4

L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid beta-protein precursor gamma-secretase activity.

Shearman MS, Beher D, Clarke EE, Lewis HD, Harrison T, Hunt P, Nadin A, Smith AL, Stevenson G, Castro JL. Shearman MS, et al. Among authors: lewis hd. Biochemistry. 2000 Aug 1;39(30):8698-704. doi: 10.1021/bi0005456. Biochemistry. 2000. PMID: 10913280

5

A new series of potent benzodiazepine gamma-secretase inhibitors.

Churcher I, Ashton K, Butcher JW, Clarke EE, Harrison T, Lewis HD, Owens AP, Teall MR, Williams S, Wrigley JD. Churcher I, et al. Bioorg Med Chem Lett. 2003 Jan 20;13(2):179-83. doi: 10.1016/s0960-894x(02)00909-5. Bioorg Med Chem Lett. 2003. PMID: 12482419

6

High affinity, bioavailable 3-amino-1,4-benzodiazepine-based gamma-secretase inhibitors.

Owens AP, Nadin A, Talbot AC, Clarke EE, Harrison T, Lewis HD, Reilly M, Wrigley JD, Castro JL. Owens AP, et al. Bioorg Med Chem Lett. 2003 Nov 17;13(22):4143-5. doi: 10.1016/j.bmcl.2003.07.031. Bioorg Med Chem Lett. 2003. PMID: 14592525

7

4-substituted cyclohexyl sulfones as potent, orally active gamma-secretase inhibitors.

Churcher I, Beher D, Best JD, Castro JL, Clarke EE, Gentry A, Harrison T, Hitzel L, Kay E, Kerrad S, Lewis HD, Morentin-Gutierrez P, Mortishire-Smith R, Oakley PJ, Reilly M, Shaw DE, Shearman MS, Teall MR, Williams S, Wrigley JD. Churcher I, et al. Bioorg Med Chem Lett. 2006 Jan 15;16(2):280-4. doi: 10.1016/j.bmcl.2005.10.009. Epub 2005 Nov 3. Bioorg Med Chem Lett. 2006. PMID: 16275079

8

Cyclic sulfamide gamma-secretase inhibitors.

Sparey T, Beher D, Best J, Biba M, Castro JL, Clarke E, Hannam J, Harrison T, Lewis H, Madin A, Shearman M, Sohal B, Tsou N, Welch C, Wrigley J. Sparey T, et al. Among authors: lewis h. Bioorg Med Chem Lett. 2005 Oct 1;15(19):4212-6. doi: 10.1016/j.bmcl.2005.06.084. Bioorg Med Chem Lett. 2005. PMID: 16054361

9

A comparative assessment of gamma-secretase activity in transgenic and non-transgenic rodent brain.

Goggi JL, Lewis HD, Mok J, Harrison T, Shearman MS, Atack JR, Best JD. Goggi JL, et al. J Neurosci Methods. 2006 Oct 30;157(2):246-52. doi: 10.1016/j.jneumeth.2006.05.001. Epub 2006 Jul 21. J Neurosci Methods. 2006. PMID: 16859750

10

The novel gamma secretase inhibitor N-[cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide (MRK-560) reduces amyloid plaque deposition without evidence of notch-related pathology in the Tg2576 mouse.

Best JD, Smith DW, Reilly MA, O'Donnell R, Lewis HD, Ellis S, Wilkie N, Rosahl TW, Laroque PA, Boussiquet-Leroux C, Churcher I, Atack JR, Harrison T, Shearman MS. Best JD, et al. J Pharmacol Exp Ther. 2007 Feb;320(2):552-8. doi: 10.1124/jpet.106.114330. Epub 2006 Nov 10. J Pharmacol Exp Ther. 2007. PMID: 17099072

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