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Generation and display of activity-weighted chemical hyperstructures.
Brown N, Willett P, Wilton DJ, Lewis RA. Brown N, et al. Among authors: lewis ra. J Chem Inf Comput Sci. 2003 Jan-Feb;43(1):288-97. doi: 10.1021/ci0103875. J Chem Inf Comput Sci. 2003. PMID: 12546564
A general method for exploiting QSAR models in lead optimization.
Lewis RA. Lewis RA. J Med Chem. 2005 Mar 10;48(5):1638-48. doi: 10.1021/jm049228d. J Med Chem. 2005. PMID: 15743205
Three-dimensional quantitative structure-permeability relationship analysis for a series of inhibitors of rhinovirus replication.
Ekins S, Durst GL, Stratford RE, Thorner DA, Lewis R, Loncharich RJ, Wikel JH. Ekins S, et al. J Chem Inf Comput Sci. 2001 Nov-Dec;41(6):1578-86. doi: 10.1021/ci010330i. J Chem Inf Comput Sci. 2001. PMID: 11749585
Factor Xa inhibitors (Berlex).
Lewis RA. Lewis RA. IDrugs. 2000 May;3(5):525-9. IDrugs. 2000. PMID: 16100685
Lessons in molecular recognition: the effects of ligand and protein flexibility on molecular docking accuracy.
Erickson JA, Jalaie M, Robertson DH, Lewis RA, Vieth M. Erickson JA, et al. Among authors: lewis ra. J Med Chem. 2004 Jan 1;47(1):45-55. doi: 10.1021/jm030209y. J Med Chem. 2004. PMID: 14695819
Synthesis, pharmacological characterization, and molecular modeling of heterobicyclic amino acids related to (+)-2-aminobicyclo[3.1.0] hexane-2,6-dicarboxylic acid (LY354740): identification of two new potent, selective, and systemically active agonists for group II metabotropic glutamate receptors.
Monn JA, Valli MJ, Massey SM, Hansen MM, Kress TJ, Wepsiec JP, Harkness AR, Grutsch JL Jr, Wright RA, Johnson BG, Andis SL, Kingston A, Tomlinson R, Lewis R, Griffey KR, Tizzano JP, Schoepp DD. Monn JA, et al. Among authors: lewis r. J Med Chem. 1999 Mar 25;42(6):1027-40. doi: 10.1021/jm980616n. J Med Chem. 1999. PMID: 10090786
Mild parenchymal lung disease is still lung disease.
Condliffe R, Kiely DG, Lewis RA. Condliffe R, et al. Among authors: lewis ra. Eur Respir J. 2020 Nov 26;56(5):2003727. doi: 10.1183/13993003.03727-2020. Print 2020 Nov. Eur Respir J. 2020. PMID: 33243774 No abstract available.
Quantitative Evidence Synthesis Methods for the Assessment of the Effectiveness of Treatment Sequences for Clinical and Economic Decision Making: A Review and Taxonomy of Simplifying Assumptions.
Lewis RA, Hughes D, Sutton AJ, Wilkinson C. Lewis RA, et al. Pharmacoeconomics. 2020 Nov 26. doi: 10.1007/s40273-020-00980-w. Online ahead of print. Pharmacoeconomics. 2020. PMID: 33242191 Review.
An autosomal dominant neurological disorder caused by de novo variants in FAR1 resulting in uncontrolled synthesis of ether lipids.
Ferdinandusse S, McWalter K, Te Brinke H, IJlst L, Mooijer PM, Ruiter JPN, van Lint AEM, Pras-Raves M, Wever E, Millan F, Guillen Sacoto MJ, Begtrup A, Tarnopolsky M, Brady L, Ladda RL, Sell SL, Nowak CB, Douglas J, Tian C, Ulm E, Perlman S, Drack AV, Chong K, Martin N, Brault J, Brokamp E, Toro C, Gahl WA, Macnamara EF, Wolfe L; Undiagnosed Diseases Network, Waisfisz Q, Zwijnenburg PJG, Ziegler A, Barth M, Smith R, Ellingwood S, Gaebler-Spira D, Bakhtiari S, Kruer MC, van Kampen AHC, Wanders RJA, Waterham HR, Cassiman D, Vaz FM. Ferdinandusse S, et al. Genet Med. 2020 Nov 26. doi: 10.1038/s41436-020-01027-3. Online ahead of print. Genet Med. 2020. PMID: 33239752
Effect of Ezogabine on Cortical and Spinal Motor Neuron Excitability in Amyotrophic Lateral Sclerosis: A Randomized Clinical Trial.
Wainger BJ, Macklin EA, Vucic S, McIlduff CE, Paganoni S, Maragakis NJ, Bedlack R, Goyal NA, Rutkove SB, Lange DJ, Rivner MH, Goutman SA, Ladha SS, Mauricio EA, Baloh RH, Simmons Z, Pothier L, Kassis SB, La T, Hall M, Evora A, Klements D, Hurtado A, Pereira JD, Koh J, Celnik PA, Chaudhry V, Gable K, Juel VC, Phielipp N, Marei A, Rosenquist P, Meehan S, Oskarsson B, Lewis RA, Kaur D, Kiskinis E, Woolf CJ, Eggan K, Weiss MD, Berry JD, David WS, Davila-Perez P, Camprodon JA, Pascual-Leone A, Kiernan MC, Shefner JM, Atassi N, Cudkowicz ME. Wainger BJ, et al. Among authors: lewis ra. JAMA Neurol. 2020 Nov 23:e204300. doi: 10.1001/jamaneurol.2020.4300. Online ahead of print. JAMA Neurol. 2020. PMID: 33226425
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