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HDAC6 inhibition results in tau acetylation and modulates tau phosphorylation and degradation in oligodendrocytes.
Noack M, Leyk J, Richter-Landsberg C. Noack M, et al. Among authors: leyk j. Glia. 2014 Apr;62(4):535-47. doi: 10.1002/glia.22624. Epub 2014 Jan 24. Glia. 2014. PMID: 24464872
ADNP/ADNP2 expression in oligodendrocytes: implication for myelin-related neurodevelopment.
Malishkevich A, Leyk J, Goldbaum O, Richter-Landsberg C, Gozes I. Malishkevich A, et al. Among authors: leyk j. J Mol Neurosci. 2015 Oct;57(2):304-13. doi: 10.1007/s12031-015-0640-4. J Mol Neurosci. 2015. PMID: 26315608
HDAC6 inhibition by tubastatin A is protective against oxidative stress in a photoreceptor cell line and restores visual function in a zebrafish model of inherited blindness.
Leyk J, Daly C, Janssen-Bienhold U, Kennedy BN, Richter-Landsberg C. Leyk J, et al. Cell Death Dis. 2017 Aug 31;8(8):e3028. doi: 10.1038/cddis.2017.415. Cell Death Dis. 2017. PMID: 29048427 Free PMC article.
Inhibition of HDAC6 modifies tau inclusion body formation and impairs autophagic clearance.
Leyk J, Goldbaum O, Noack M, Richter-Landsberg C. Leyk J, et al. J Mol Neurosci. 2015 Apr;55(4):1031-46. doi: 10.1007/s12031-014-0460-y. Epub 2014 Dec 2. J Mol Neurosci. 2015. PMID: 25434725
Inclusion body formation, macroautophagy, and the role of HDAC6 in neurodegeneration.
Richter-Landsberg C, Leyk J. Richter-Landsberg C, et al. Among authors: leyk j. Acta Neuropathol. 2013 Dec;126(6):793-807. doi: 10.1007/s00401-013-1158-x. Epub 2013 Aug 3. Acta Neuropathol. 2013. PMID: 23912309 Review.