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The IL-4Rα Q576R polymorphism is associated with increased severity of atopic dermatitis and exaggerates allergic skin inflammation in mice.
Yang B, Wilkie H, Das M, Timilshina M, Bainter W, Woods B, Daya M, Boorgula MP, Mathias RA, Lai P, Petty CR, Weller E, Harb H, Chatila TA, Leung DYM, Beck LA, Simpson EL, Hata TR, Barnes KC, Phipatanakul W, Leyva-Castillo JM, Geha RS. Yang B, et al. Among authors: leyva castillo jm. J Allergy Clin Immunol. 2023 May;151(5):1296-1306.e7. doi: 10.1016/j.jaci.2023.01.011. Epub 2023 Jan 21. J Allergy Clin Immunol. 2023. PMID: 36690254
IL-23 induced in keratinocytes by endogenous TLR4 ligands polarizes dendritic cells to drive IL-22 responses to skin immunization.
Yoon J, Leyva-Castillo JM, Wang G, Galand C, Oyoshi MK, Kumar L, Hoff S, He R, Chervonsky A, Oppenheim JJ, Kuchroo VK, van den Brink MR, Malefyt Rde W, Tessier PA, Fuhlbrigge R, Rosenstiel P, Terhorst C, Murphy G, Geha RS. Yoon J, et al. J Exp Med. 2016 Sep 19;213(10):2147-66. doi: 10.1084/jem.20150376. Epub 2016 Aug 22. J Exp Med. 2016. PMID: 27551155 Free PMC article.
RORα-expressing T regulatory cells restrain allergic skin inflammation.
Malhotra N, Leyva-Castillo JM, Jadhav U, Barreiro O, Kam C, O'Neill NK, Meylan F, Chambon P, von Andrian UH, Siegel RM, Wang EC, Shivdasani R, Geha RS. Malhotra N, et al. Sci Immunol. 2018 Mar 2;3(21):eaao6923. doi: 10.1126/sciimmunol.aao6923. Sci Immunol. 2018. PMID: 29500225 Free PMC article.
33 results