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1998 1
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2,112 results

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Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche.
Sato T, Vries RG, Snippert HJ, van de Wetering M, Barker N, Stange DE, van Es JH, Abo A, Kujala P, Peters PJ, Clevers H. Sato T, et al. Nature. 2009 May 14;459(7244):262-5. doi: 10.1038/nature07935. Epub 2009 Mar 29. Nature. 2009. PMID: 19329995
Single sorted Lgr5(+) stem cells can also initiate these cryptvillus organoids. Tracing experiments indicate that the Lgr5(+) stem-cell hierarchy is maintained in organoids. We conclude that intestinal cryptvillus units are self-organizing structures, which can be b …
Single sorted Lgr5(+) stem cells can also initiate these cryptvillus organoids. Tracing experiments indicate that the Lgr5(+) …
Identification of stem cells in small intestine and colon by marker gene Lgr5.
Barker N, van Es JH, Kuipers J, Kujala P, van den Born M, Cozijnsen M, Haegebarth A, Korving J, Begthel H, Peters PJ, Clevers H. Barker N, et al. Nature. 2007 Oct 25;449(7165):1003-7. doi: 10.1038/nature06196. Epub 2007 Oct 14. Nature. 2007. PMID: 17934449
Here, using two knock-in alleles, we reveal exclusive expression of Lgr5 in cycling columnar cells at the crypt base. In addition, Lgr5 was expressed in rare cells in several other tissues. ...The expression pattern of Lgr5 suggests that it marks stem cells i …
Here, using two knock-in alleles, we reveal exclusive expression of Lgr5 in cycling columnar cells at the crypt base. In addition, …
The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength.
de Lau W, Peng WC, Gros P, Clevers H. de Lau W, et al. Genes Dev. 2014 Feb 15;28(4):305-16. doi: 10.1101/gad.235473.113. Genes Dev. 2014. PMID: 24532711 Free PMC article. Review.
Lgr5 was originally discovered as a common Wnt target gene in adult intestinal crypts and colon cancer. ...The Lgr5/R-spondin complex acts by neutralizing Rnf43 and Znrf3, two transmembrane E3 ligases that remove Wnt receptors from the stem cell surface. ...
Lgr5 was originally discovered as a common Wnt target gene in adult intestinal crypts and colon cancer. ...The Lgr5/R-spondin …
Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts.
Sato T, van Es JH, Snippert HJ, Stange DE, Vries RG, van den Born M, Barker N, Shroyer NF, van de Wetering M, Clevers H. Sato T, et al. Nature. 2011 Jan 20;469(7330):415-8. doi: 10.1038/nature09637. Epub 2010 Nov 28. Nature. 2011. PMID: 21113151 Free PMC article.
Here we find a close physical association of Lgr5 stem cells with Paneth cells in mice, both in vivo and in vitro. ...Genetic removal of Paneth cells in vivo results in the concomitant loss of Lgr5 stem cells. In colon crypts, CD24(+) cells residing between Lgr5 …
Here we find a close physical association of Lgr5 stem cells with Paneth cells in mice, both in vivo and in vitro. ...Genetic removal …
In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration.
Huch M, Dorrell C, Boj SF, van Es JH, Li VS, van de Wetering M, Sato T, Hamer K, Sasaki N, Finegold MJ, Haft A, Vries RG, Grompe M, Clevers H. Huch M, et al. Nature. 2013 Feb 14;494(7436):247-50. doi: 10.1038/nature11826. Epub 2013 Jan 27. Nature. 2013. PMID: 23354049 Free PMC article.
A crucial component of the culture medium is the Wnt agonist RSPO1, the recently discovered ligand of LGR5. Here we show that Lgr5-lacZ is not expressed in healthy adult liver, however, small Lgr5-LacZ(+) cells appear near bile ducts upon damage, coinciding w …
A crucial component of the culture medium is the Wnt agonist RSPO1, the recently discovered ligand of LGR5. Here we show that Lgr5 …
Identification of Quiescent LGR5(+) Stem Cells in the Human Colon.
Ishikawa K, Sugimoto S, Oda M, Fujii M, Takahashi S, Ohta Y, Takano A, Ishimaru K, Matano M, Yoshida K, Hanyu H, Toshimitsu K, Sawada K, Shimokawa M, Saito M, Kawasaki K, Ishii R, Taniguchi K, Imamura T, Kanai T, Sato T. Ishikawa K, et al. Gastroenterology. 2022 Nov;163(5):1391-1406.e24. doi: 10.1053/j.gastro.2022.07.081. Epub 2022 Aug 11. Gastroenterology. 2022. PMID: 35963362 Free article.
To trace the fate of human colonic stem or differentiated cells, we generated LGR5-tdTomato, LGR5-iCasase9-tdTomato, LGR5-split-Cre, and KRT20-ERCreER knock-in human colon organoids via genome engineering. p27(+) dormant cells were further visualized with the …
To trace the fate of human colonic stem or differentiated cells, we generated LGR5-tdTomato, LGR5-iCasase9-tdTomato, LGR5 …
Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells.
Snippert HJ, van der Flier LG, Sato T, van Es JH, van den Born M, Kroon-Veenboer C, Barker N, Klein AM, van Rheenen J, Simons BD, Clevers H. Snippert HJ, et al. Cell. 2010 Oct 1;143(1):134-44. doi: 10.1016/j.cell.2010.09.016. Cell. 2010. PMID: 20887898 Free article.
Intestinal stem cells, characterized by high Lgr5 expression, reside between Paneth cells at the small intestinal crypt base and divide every day. ...We have collected short- and long-term clonal tracing data of individual Lgr5(hi) cells. These reveal that most L …
Intestinal stem cells, characterized by high Lgr5 expression, reside between Paneth cells at the small intestinal crypt base and divi …
Plasticity of Lgr5-Negative Cancer Cells Drives Metastasis in Colorectal Cancer.
Fumagalli A, Oost KC, Kester L, Morgner J, Bornes L, Bruens L, Spaargaren L, Azkanaz M, Schelfhorst T, Beerling E, Heinz MC, Postrach D, Seinstra D, Sieuwerts AM, Martens JWM, van der Elst S, van Baalen M, Bhowmick D, Vrisekoop N, Ellenbroek SIJ, Suijkerbuijk SJE, Snippert HJ, van Rheenen J. Fumagalli A, et al. Cell Stem Cell. 2020 Apr 2;26(4):569-578.e7. doi: 10.1016/j.stem.2020.02.008. Epub 2020 Mar 12. Cell Stem Cell. 2020. PMID: 32169167 Free PMC article.
Colorectal cancer stem cells (CSCs) express Lgr5 and display extensive stem cell-like multipotency and self-renewal and are thought to seed metastatic disease. ...We found that most disseminated CRC cells in circulation were Lgr5(-) and formed distant metastases in …
Colorectal cancer stem cells (CSCs) express Lgr5 and display extensive stem cell-like multipotency and self-renewal and are thought t …
Lgr5-mediated p53 Repression through PDCD5 leads to doxorubicin resistance in Hepatocellular Carcinoma.
Ma Z, Guo D, Wang Q, Liu P, Xiao Y, Wu P, Wang Y, Chen B, Liu Z, Liu Q. Ma Z, et al. Theranostics. 2019 May 9;9(10):2967-2983. doi: 10.7150/thno.30562. eCollection 2019. Theranostics. 2019. PMID: 31244936 Free PMC article.
A two-hybrid analysis, using the Lgr5 gene as the bait and a HCC cDNA library, was used to screen targeted proteins that interact with Lgr5. ...We identified programmed cell death protein 5 (PDCD5) as a target gene of Lgr5 and we found that PDCD5 was responsi …
A two-hybrid analysis, using the Lgr5 gene as the bait and a HCC cDNA library, was used to screen targeted proteins that interact wit …
Visualization and targeting of LGR5(+) human colon cancer stem cells.
Shimokawa M, Ohta Y, Nishikori S, Matano M, Takano A, Fujii M, Date S, Sugimoto S, Kanai T, Sato T. Shimokawa M, et al. Nature. 2017 May 11;545(7653):187-192. doi: 10.1038/nature22081. Epub 2017 Mar 29. Nature. 2017. PMID: 28355176
Lineage-tracing experiments with a tamoxifen-inducible Cre knock-in allele of LGR5 reveal the self-renewal and differentiation capacity of LGR5(+) tumour cells. Selective ablation of LGR5(+) CSCs in LGR5-iCaspase9 knock-in organoids leads to tumour reg …
Lineage-tracing experiments with a tamoxifen-inducible Cre knock-in allele of LGR5 reveal the self-renewal and differentiation capaci …
2,112 results