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Page 1
Deciphering the synergistic mechanism of quorum sensing and sulfate-reducing bacteria for directed acetate conversion during sludge fermentation.
Jing Y, Liu S, Li Q, Liu Z, Xu X, Luo H, He Z, Liu W, Yue X, Zhou A. Jing Y, et al. Bioresour Technol. 2026 Jul 12:135387. doi: 10.1016/j.biortech.2026.135387. Online ahead of print. Bioresour Technol. 2026. PMID: 42437578
The restricted bioconversion of C3-C5 short-chain fatty acids (SCFAs) to acetate due to thermodynamic limitations is the main bottleneck during sludge fermentation. ...The results revealed that the addition of 5 muM C8-HSL combined with io-SRB led to the highest SCFAs and …
The restricted bioconversion of C3-C5 short-chain fatty acids (SCFAs) to acetate due to thermodynamic limitations is the main bottlen …
Complement-Modulating Mechanisms of Ginkgo biloba Extract in Dry AMD: Insights From Molecular Docking and Dynamics Simulations.
Huang T, Jiang D, Wang D, Dong Z, Hou Y, Li X, Deng X, Liu X. Huang T, et al. Transl Vis Sci Technol. 2026 Jun 1;15(6):13. doi: 10.1167/tvst.15.6.13. Transl Vis Sci Technol. 2026. PMID: 42257412 Free PMC article.
METHODS: Bioinformatics analysis was used to identify dry AMD-related targets, followed by molecular docking and 100-ns MD simulations to evaluate the binding stability and free energy of EGb 761 components with complement proteins C3 and C5. RESULTS: Quercetin and ginkgol …
METHODS: Bioinformatics analysis was used to identify dry AMD-related targets, followed by molecular docking and 100-ns MD simulations to ev …
Efficacy of Tonlamarsen in Patients With Uncontrolled Hypertension: The KARDINAL Phase 2 Randomized Clinical Trial.
Laffin LJ, Wang Q, Sarraju A, Touyz RM, Schlaich MP, Cohen DL, Mahfoud F, Mitchell LM, Mitchell J, Wolski K, Dennis P, Akere A, Li W, Chen G, Cohen YZ, Kim J, Cooper CG, Ramesan P, Edelberg JM, Nissen SE; KARDINAL Investigators. Laffin LJ, et al. J Am Coll Cardiol. 2026 May 12;87(18):2508-2520. doi: 10.1016/j.jacc.2026.03.034. Epub 2026 Mar 28. J Am Coll Cardiol. 2026. PMID: 41949512 Free article. Clinical Trial.
Longitudinal investigation of the T helper (Th)1-Th2 balance and complement system in clinical high risk for psychosis cohort.
Zhang T, Zhao J, Tang X, Wei Y, Ju M, Zhang D, Tang Y, Cui H, Yi Z, Liu X, Liu H, Wang Z, Chen T, Gao J, Hu Q, Zeng L, Li C, Wang J. Zhang T, et al. Transl Psychiatry. 2026 Mar 23;16(1):228. doi: 10.1038/s41398-025-03695-8. Transl Psychiatry. 2026. PMID: 41872173 Free PMC article.
Additionally, the levels of thirteen complement proteins (C1q, C2, C3, C3b, C4, C4b, C5, C5a, factor B, D, I, H, and Mannose-Binding Lectin) were measured at baseline. Correlations between cytokines and complement factors were examined, and longitudinal changes were …
Additionally, the levels of thirteen complement proteins (C1q, C2, C3, C3b, C4, C4b, C5, C5a, factor B, D, I, H, and Mannose-B …
Unraveling Interaction Chemistry between Saturated Methyl Esters and Nitrogen Dioxide: An Ab Initio Kinetic Study on H-Atom Abstraction Reactions.
Kong R, Zhu Z, La N, Ying Y, Li F, Han D, Ren Z, Wang H, Duan Y. Kong R, et al. J Phys Chem A. 2026 Mar 5;130(9):1882-1896. doi: 10.1021/acs.jpca.5c06819. Epub 2026 Feb 23. J Phys Chem A. 2026. PMID: 41728636
High-level ab initio kinetic calculations were carried out to investigate H-atom abstraction reactions from C2-C5 saturated methyl esters by NO(2). Five small molecule esters, including methyl formate, methyl ethanoate, methyl propanoate, methyl butanoate, and methyl iso-b …
High-level ab initio kinetic calculations were carried out to investigate H-atom abstraction reactions from C2-C5 saturated methyl es …
Chemoenzymatic Synthesis of Arisugacins and Terreulactones via Directed Evolution of a Privileged Sclareolide Dioxygenase.
Liu X, Feng Y, Yuan C, Li L, Li J. Liu X, et al. J Am Chem Soc. 2026 Mar 4;148(8):9031-9039. doi: 10.1021/jacs.5c22624. Epub 2026 Feb 17. J Am Chem Soc. 2026. PMID: 41703730
A C5-hydroxylation module streamlines access to (+)-phorbadione via a concise formal synthesis from sclareolide. Orthogonal C1/C3/C5 oxidation, combined with Suarez oxidative cleavage and an amine-catalyzed formal [3 + 3] annulation, converges on a common diol that …
A C5-hydroxylation module streamlines access to (+)-phorbadione via a concise formal synthesis from sclareolide. Orthogonal C1/C3/ …
1,2-propanediol metabolism by heterofermentative lactobacilli in sourdough.
Li Q, Pham VD, Gänzle M. Li Q, et al. Int J Food Microbiol. 2026 Apr 16;451:111676. doi: 10.1016/j.ijfoodmicro.2026.111676. Epub 2026 Feb 2. Int J Food Microbiol. 2026. PMID: 41643526 Free article.
Lentilactobacillus buchneri FUA3252 demonstrated high 1,2-propanediol production in modified MRS (mMRS) medium with lactate, while Furfurilactobacillus spp. exhibited minimal 1,2-propanediol synthesis but produced notable amounts of mannitol. In sorghum sourdough, Ff. cerealis …
Lentilactobacillus buchneri FUA3252 demonstrated high 1,2-propanediol production in modified MRS (mMRS) medium with lactate, while Furfurila …
Discovery and Evaluation of Novel Calenduloside E Derivatives Targeting HSP90β in Ox-LDL-Induced HUVECs Injury.
Han F, Fang H, Li G, Deng D, Sun G, Tian Y. Han F, et al. Pharmaceuticals (Basel). 2026 Jan 2;19(1):90. doi: 10.3390/ph19010090. Pharmaceuticals (Basel). 2026. PMID: 41599689 Free PMC article.
Additionally, SPR results indicated that C5 and CE had similar binding affinities to HSP90beta, with dissociation constants (K(D)) of 1.73 muM and 1.72 muM, respectively. MST demonstrated that C5 binds to HSP90beta with an affinity 111 times higher than that …
Additionally, SPR results indicated that C5 and CE had similar binding affinities to HSP90beta, with dissociation constants (K(D
Penimeroandranoids A-D, DMOA-Derived Meroterpenoids from the Soil Fungus Penicillium sp. sb62 and Their Bioactivities.
Chang JL, Zhou YH, Huang YX, Liu J, Huang ZJ, Hu JY, Qin CL, Li WP, Peng HM, Fang J, Jin A, Ruan HL. Chang JL, et al. Org Lett. 2026 Jan 30;28(4):1424-1429. doi: 10.1021/acs.orglett.5c05302. Epub 2026 Jan 15. Org Lett. 2026. PMID: 41536230
Four meroterpenoids derived from 3,5-dimethylorsellinic acid (DMOA), penimeroandranoids A-D (1-4), were isolated from the fermentation of the soil-derived fungus Penicillium sp. sb62. ...Penimeroandranoid C (3) represents the first example of a meroterpenoid harboring a 6/ …
Four meroterpenoids derived from 3,5-dimethylorsellinic acid (DMOA), penimeroandranoids A-D (1-4), were isolated from the fermentatio …
Photocatalyzed Decarboxylative Thio(seleno)etherification of Redox-Active Uronates Enables Synthesis of Rare Sugar Thio(seleno)glycosides.
Zhang X, Ding H, Zhang J, Sun C, Cui D, Song N, Wang P, Liu XW, Li M. Zhang X, et al. Org Lett. 2026 Jan 23;28(3):1036-1041. doi: 10.1021/acs.orglett.5c05122. Epub 2026 Jan 8. Org Lett. 2026. PMID: 41504328
We here present a novel approach to such constructs from readily available C-glycosides with photocatalyzed decarboxylative thio(seleno)etherification of redox-active uronates as the key transformation following a C1-to-C5 switch strategy. This protocol tolerates diverse s …
We here present a novel approach to such constructs from readily available C-glycosides with photocatalyzed decarboxylative thio(seleno)ethe …
190 results