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8,774 results
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The interactome of LIM domain proteins: the contributions of LIM domain proteins to heart failure and heart development.
Li A, Ponten F, dos Remedios CG. Li A, et al. Proteomics. 2012 Jan;12(2):203-25. doi: 10.1002/pmic.201100492. Epub 2012 Jan 4. Proteomics. 2012. PMID: 22253135 Review.
They belong to a large family and here we review those expressed mainly in mammalian hearts, but particularly in cardiomyocytes. ...This multiplicity of binding partners probably protects the heart as it is challenged to maintain cardiac output, until the imbalance reaches …
They belong to a large family and here we review those expressed mainly in mammalian hearts, but particularly in cardiomyocytes. ...T …
Heart research advances using database search engines, Human Protein Atlas and the Sydney Heart Bank.
Li A, Estigoy C, Raftery M, Cameron D, Odeberg J, Pontén F, Lal S, Dos Remedios CG. Li A, et al. Heart Lung Circ. 2013 Oct;22(10):819-26. doi: 10.1016/j.hlc.2013.06.006. Epub 2013 Jul 13. Heart Lung Circ. 2013. PMID: 23856366 Review.
This Methodological Review is intended as a guide for research students who may have just discovered a human "novel" cardiac protein, but it may also help hard-pressed reviewers of journal submissions on a "novel" protein reported in an animal model of human …
This Methodological Review is intended as a guide for research students who may have just discovered a human "novel" cardiac p …
Ablation of cardiac myosin binding protein-C disrupts the super-relaxed state of myosin in murine cardiomyocytes.
McNamara JW, Li A, Smith NJ, Lal S, Graham RM, Kooiker KB, van Dijk SJ, Remedios CGD, Harris SP, Cooke R. McNamara JW, et al. J Mol Cell Cardiol. 2016 May;94:65-71. doi: 10.1016/j.yjmcc.2016.03.009. Epub 2016 Mar 26. J Mol Cell Cardiol. 2016. PMID: 27021517 Free PMC article.
Cardiac myosin binding protein-C (cMyBP-C) is a structural and regulatory component of cardiac thick filaments. It is observed in electron micrographs as seven to nine transverse stripes in the central portion of each half of the A band. ...In cardiac cells there ex …
Cardiac myosin binding protein-C (cMyBP-C) is a structural and regulatory component of cardiac thick filaments. It is observed in ele …
Tissue microarray profiling in human heart failure.
Lal S, Nguyen L, Tezone R, Ponten F, Odeberg J, Li A, Dos Remedios C. Lal S, et al. Proteomics. 2016 Sep;16(17):2319-26. doi: 10.1002/pmic.201600135. Epub 2016 Aug 11. Proteomics. 2016. PMID: 27364902
Tissue MicroArrays (TMAs) are a versatile tool for high-throughput protein screening, allowing qualitative analysis of a large number of samples on a single slide. ...In a pilot study, we applied our TMAs to screen for the expression of four-and-a
Tissue MicroArrays (TMAs) are a versatile tool for high-throughput protein screening, allowing qualitative analysis of a large …
Increased collagen within the transverse tubules in human heart failure.
Crossman DJ, Shen X, Jüllig M, Munro M, Hou Y, Middleditch M, Shrestha D, Li A, Lal S, Dos Remedios CG, Baddeley D, Ruygrok PN, Soeller C. Crossman DJ, et al. Cardiovasc Res. 2017 Jul 1;113(8):879-891. doi: 10.1093/cvr/cvx055. Cardiovasc Res. 2017. PMID: 28444133
T-tubules in human failing hearts exhibit increased labelling by wheat germ agglutinin (WGA), a lectin that binds to the dystrophin-associated glycoprotein complex. ...Western blots probed with WGA reveal a 5.7-fold increase in a 140 kDa band in IDCM. Mass sp …
T-tubules in human failing hearts exhibit increased labelling by wheat germ agglutinin (WGA), a lectin that binds to the dystrophin-a …
Special Issue on human heart failure.
Li A, Dos Remedios CG. Li A, et al. Biophys Rev. 2015 Mar;7(1):1-3. doi: 10.1007/s12551-014-0161-3. Epub 2015 Jan 27. Biophys Rev. 2015. PMID: 28509983 Free PMC article. No abstract available.
Pathogenesis and pathophysiology of heart failure with reduced ejection fraction: translation to human studies.
Ge Z, Li A, McNamara J, Dos Remedios C, Lal S. Ge Z, et al. Heart Fail Rev. 2019 Sep;24(5):743-758. doi: 10.1007/s10741-019-09806-0. Heart Fail Rev. 2019. PMID: 31209771 Review.
Most commonly, HFrEF is centred on a reactive model where a significant initial insult leads to reduced cardiac output, further triggering a cascade of maladaptive processes. ...Nevertheless, there are increasing calls for a proximal, 'cardiocentric' a …
Most commonly, HFrEF is centred on a reactive model where a significant initial insult leads to reduced cardiac output, furthe …
Molecular effects of the myosin activator omecamtiv mecarbil on contractile properties of skinned myocardium lacking cardiac myosin binding protein-C.
Mamidi R, Gresham KS, Li A, dos Remedios CG, Stelzer JE. Mamidi R, et al. J Mol Cell Cardiol. 2015 Aug;85:262-72. doi: 10.1016/j.yjmcc.2015.06.011. Epub 2015 Jun 20. J Mol Cell Cardiol. 2015. PMID: 26100051 Free PMC article.
The myosin activator omecamtiv mecarbil (OM) is a pharmacological drug that specifically targets the myosin XB and recent evidence suggests that OM induces a significant decrease in the in vivo motility velocity and an increase in the XB duty cycle. ...Samples from …
The myosin activator omecamtiv mecarbil (OM) is a pharmacological drug that specifically targets the myosin XB and recent evidence su …
Best Practice BioBanking of Human Heart Tissue.
Lal S, Li A, Allen D, Allen PD, Bannon P, Cartmill T, Cooke R, Farnsworth A, Keogh A, Dos Remedios C. Lal S, et al. Biophys Rev. 2015 Dec;7(4):399-406. doi: 10.1007/s12551-015-0182-6. Epub 2015 Nov 2. Biophys Rev. 2015. PMID: 26998172 Free PMC article.
This review provides a guide to researchers who wish to establish a biobank. It also gives practical advice to investigators seeking access to samples of healthy or diseased human hearts. We begin with a brief history of the Sydney Heart Bank (SHB) from when …
This review provides a guide to researchers who wish to establish a biobank. It also gives practical advice to investigators s …
Abnormal contractility in human heart myofibrils from patients with dilated cardiomyopathy due to mutations in TTN and contractile protein genes.
Vikhorev PG, Smoktunowicz N, Munster AB, Copeland O, Kostin S, Montgiraud C, Messer AE, Toliat MR, Li A, Dos Remedios CG, Lal S, Blair CA, Campbell KS, Guglin M, Richter M, Knöll R, Marston SB. Vikhorev PG, et al. Sci Rep. 2017 Nov 1;7(1):14829. doi: 10.1038/s41598-017-13675-8. Sci Rep. 2017. PMID: 29093449 Free PMC article.
In this study we isolated cardiac myofibrils from 3 TTNtv mutants, and 3 with contractile protein mutations (TNNI3 K36Q, TNNC1 G159D and MYH7 E1426K) and measured their contractility and passive stiffness in comparison with donor heart muscle as a control. ...The decrease …
In this study we isolated cardiac myofibrils from 3 TTNtv mutants, and 3 with contractile protein mutations (TNNI3 K36Q, TNNC1 G159D and MYH …
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