Li AP - Search Results

1

Higher throughput human hepatocyte assays for the evaluation of time-dependent inhibition of CYP3A4.

Li AP, Doshi U. Li AP, et al. Drug Metab Lett. 2011 Aug;5(3):183-91. doi: 10.2174/187231211796904964. Drug Metab Lett. 2011. PMID: 21722087

2

Effects of culture duration on gene expression of P450 isoforms, uptake and efflux transporters in primary hepatocytes cultured in the absence and presence of interleukin-6: implications for experimental design for the evaluation of downregulatory effects of biotherapeutics.

Yang Q, Doshi U, Li N, Li AP. Yang Q, et al. Among authors: li ap, li n. Curr Drug Metab. 2012 Sep 1;13(7):938-46. doi: 10.2174/138920012802138570. Curr Drug Metab. 2012. PMID: 22475270

3

A Novel Plated Hepatocyte Relay Assay (PHRA) for In Vitro Evaluation of Hepatic Metabolic Clearance of Slowly Metabolized Compounds.

Peng CC, Doshi U, Prakash C, Li AP. Peng CC, et al. Among authors: li ap. Drug Metab Lett. 2016;10(1):3-15. doi: 10.2174/1872312809666150818111500. Drug Metab Lett. 2016. PMID: 26282592

4

Human Enterocytes as an In Vitro Model for the Evaluation of Intestinal Drug Metabolism: Characterization of Drug-Metabolizing Enzyme Activities of Cryopreserved Human Enterocytes from Twenty-Four Donors.

Ho MD, Ring N, Amaral K, Doshi U, Li AP. Ho MD, et al. Among authors: li ap. Drug Metab Dispos. 2017 Jun;45(6):686-691. doi: 10.1124/dmd.116.074377. Epub 2017 Apr 10. Drug Metab Dispos. 2017. PMID: 28396528

5

Utility of Pooled Cryopreserved Human Enterocytes as an In vitro Model for Assessing Intestinal Clearance and Drug-Drug Interactions.

Wong S, Doshi U, Vuong P, Liu N, Tay S, Le H, Kosaka M, Kenny JR, Li AP, Yan Z. Wong S, et al. Among authors: li ap. Drug Metab Lett. 2018;12(1):3-13. doi: 10.2174/1872312812666171213114422. Drug Metab Lett. 2018. PMID: 29237391

6

Luciferin IPA-based higher throughput human hepatocyte screening assays for CYP3A4 inhibition and induction.

Doshi U, Li AP. Doshi U, et al. Among authors: li ap. J Biomol Screen. 2011 Sep;16(8):903-9. doi: 10.1177/1087057111414900. Epub 2011 Aug 10. J Biomol Screen. 2011. PMID: 21832258

7

Culture duration-, donor-, and medium-dependent changes in OATP1B3-mediated telmisartan uptake in human hepatocytes.

Zhu Q, Xia H, Xia CQ, Yang Q, Doshi U, Li AP, Liao M. Zhu Q, et al. Among authors: li ap. Drug Metab Lett. 2014 Jul;7(2):117-25. doi: 10.2174/1872312808666140317153311. Drug Metab Lett. 2014. PMID: 24628404

8

Evaluation of multiple mechanism-based toxicity endpoints in primary cultured human hepatocytes for the identification of drugs with clinical hepatotoxicity: Results from 152 marketed drugs with known liver injury profiles.

Zhang J, Doshi U, Suzuki A, Chang CW, Borlak J, Li AP, Tong W. Zhang J, et al. Among authors: li ap. Chem Biol Interact. 2016 Aug 5;255:3-11. doi: 10.1016/j.cbi.2015.11.008. Epub 2015 Nov 12. Chem Biol Interact. 2016. PMID: 26581450

9

Endoplasmic Reticulum Stress Induction and ERK1/2 Activation Contribute to Nefazodone-Induced Toxicity in Hepatic Cells.

Ren Z, Chen S, Zhang J, Doshi U, Li AP, Guo L. Ren Z, et al. Among authors: li ap. Toxicol Sci. 2016 Dec;154(2):368-380. doi: 10.1093/toxsci/kfw173. Epub 2016 Sep 9. Toxicol Sci. 2016. PMID: 27613715 Free PMC article.

10

Prediction of the Pharmacokinetics of Pravastatin as an OATP Substrate Using Plateable Human Hepatocytes With Human Plasma Data and PBPK Modeling.

Mao J, Doshi U, Wright M, Hop CECA, Li AP, Chen Y. Mao J, et al. Among authors: li ap. CPT Pharmacometrics Syst Pharmacol. 2018 Apr;7(4):251-258. doi: 10.1002/psp4.12283. Epub 2018 Feb 13. CPT Pharmacometrics Syst Pharmacol. 2018. PMID: 29388346 Free PMC article.

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