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Regulation of PKC-θ function by phosphorylation in T cell receptor signaling.
Wang X, Chuang HC, Li JP, Tan TH. Wang X, et al. Among authors: li jp. Front Immunol. 2012 Jul 11;3:197. doi: 10.3389/fimmu.2012.00197. eCollection 2012. Front Immunol. 2012. PMID: 22798961 Free PMC article.
The kinase GLK controls autoimmunity and NF-κB signaling by activating the kinase PKC-θ in T cells.
Chuang HC, Lan JL, Chen DY, Yang CY, Chen YM, Li JP, Huang CY, Liu PE, Wang X, Tan TH. Chuang HC, et al. Among authors: li jp. Nat Immunol. 2011 Oct 9;12(11):1113-8. doi: 10.1038/ni.2121. Nat Immunol. 2011. PMID: 21983831
Down-regulation of B cell receptor signaling by hematopoietic progenitor kinase 1 (HPK1)-mediated phosphorylation and ubiquitination of activated B cell linker protein (BLNK).
Wang X, Li JP, Kuo HK, Chiu LL, Dement GA, Lan JL, Chen DY, Yang CY, Hu H, Tan TH. Wang X, et al. Among authors: li jp. J Biol Chem. 2012 Mar 30;287(14):11037-48. doi: 10.1074/jbc.M111.310946. Epub 2012 Feb 10. J Biol Chem. 2012. PMID: 22334673 Free PMC article.
Attenuation of T cell receptor signaling by serine phosphorylation-mediated lysine 30 ubiquitination of SLP-76 protein.
Wang X, Li JP, Chiu LL, Lan JL, Chen DY, Boomer J, Tan TH. Wang X, et al. Among authors: li jp. J Biol Chem. 2012 Oct 5;287(41):34091-100. doi: 10.1074/jbc.M112.371062. Epub 2012 Aug 17. J Biol Chem. 2012. PMID: 22902619 Free PMC article.
Dual-specificity phosphatase 14 (DUSP14/MKP6) negatively regulates TCR signaling by inhibiting TAB1 activation.
Yang CY, Li JP, Chiu LL, Lan JL, Chen DY, Chuang HC, Huang CY, Tan TH. Yang CY, et al. Among authors: li jp. J Immunol. 2014 Feb 15;192(4):1547-57. doi: 10.4049/jimmunol.1300989. Epub 2014 Jan 8. J Immunol. 2014. PMID: 24403530
The phosphatase JKAP/DUSP22 inhibits T-cell receptor signalling and autoimmunity by inactivating Lck.
Li JP, Yang CY, Chuang HC, Lan JL, Chen DY, Chen YM, Wang X, Chen AJ, Belmont JW, Tan TH. Li JP, et al. Nat Commun. 2014 Apr 9;5:3618. doi: 10.1038/ncomms4618. Nat Commun. 2014. PMID: 24714587
HGK/MAP4K4 deficiency induces TRAF2 stabilization and Th17 differentiation leading to insulin resistance.
Chuang HC, Sheu WH, Lin YT, Tsai CY, Yang CY, Cheng YJ, Huang PY, Li JP, Chiu LL, Wang X, Xie M, Schneider MD, Tan TH. Chuang HC, et al. Among authors: li jp. Nat Commun. 2014 Aug 6;5:4602. doi: 10.1038/ncomms5602. Nat Commun. 2014. PMID: 25098764 Free PMC article.
GLK/MAP4K3 overexpression associates with recurrence risk for non-small cell lung cancer.
Hsu CP, Chuang HC, Lee MC, Tsou HH, Lee LW, Li JP, Tan TH. Hsu CP, et al. Among authors: li jp. Oncotarget. 2016 Jul 5;7(27):41748-41757. doi: 10.18632/oncotarget.9410. Oncotarget. 2016. PMID: 27203390 Free PMC article.
Downregulation of the phosphatase JKAP/DUSP22 in T cells as a potential new biomarker of systemic lupus erythematosus nephritis.
Chuang HC, Chen YM, Hung WT, Li JP, Chen DY, Lan JL, Tan TH. Chuang HC, et al. Among authors: li jp. Oncotarget. 2016 Sep 6;7(36):57593-57605. doi: 10.18632/oncotarget.11419. Oncotarget. 2016. PMID: 27557500 Free PMC article.
JNK pathway-associated phosphatase dephosphorylates focal adhesion kinase and suppresses cell migration.
Li JP, Fu YN, Chen YR, Tan TH. Li JP, et al. J Biol Chem. 2010 Feb 19;285(8):5472-8. doi: 10.1074/jbc.M109.060186. Epub 2009 Dec 14. J Biol Chem. 2010. PMID: 20018849 Free PMC article.
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