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Convalescent plasma with a high level of virus-specific antibody effectively neutralizes SARS-CoV-2 variants of concern.
Li M, Beck EJ, Laeyendecker O, Eby Y, Tobian AAR, Caturegli P, Wouters C, Chiklis GR, Block W, McKie RO, Joyner MJ, Wiltshire TD, Dietz AB, Gniadek TJ, Shapiro AJ, Yarava A, Lane K, Hanley DF, Bloch EM, Shoham S, Cachay ER, Meisenberg BR, Huaman MA, Fukuta Y, Patel B, Heath SL, Levine AC, Paxton JH, Anjan S, Gerber JM, Gebo KA, Casadevall A, Pekosz A, Sullivan DJ. Li M, et al. Blood Adv. 2022 Jun 28;6(12):3678-3683. doi: 10.1182/bloodadvances.2022007410. Blood Adv. 2022. PMID: 35443020 Free PMC article.
Persistent SARS-CoV-2 infection and increasing viral variants in children and young adults with impaired humoral immunity.
Truong TT, Ryutov A, Pandey U, Yee R, Goldberg L, Bhojwani D, Aguayo-Hiraldo P, Pinsky BA, Pekosz A, Shen L, Boyd SD, Wirz OF, Röltgen K, Bootwalla M, Maglinte DT, Ostrow D, Ruble D, Han JH, Biegel JA, Li M, Huang C, Sahoo MK, Pannaraj PS, O'Gorman M, Judkins AR, Gai X, Bard JD. Truong TT, et al. Among authors: li m. medRxiv [Preprint]. 2021 Mar 2:2021.02.27.21252099. doi: 10.1101/2021.02.27.21252099. medRxiv. 2021. PMID: 33688673 Free PMC article. Updated. Preprint.
Increased viral variants in children and young adults with impaired humoral immunity and persistent SARS-CoV-2 infection: A consecutive case series.
Truong TT, Ryutov A, Pandey U, Yee R, Goldberg L, Bhojwani D, Aguayo-Hiraldo P, Pinsky BA, Pekosz A, Shen L, Boyd SD, Wirz OF, Röltgen K, Bootwalla M, Maglinte DT, Ostrow D, Ruble D, Han JH, Biegel JA, Li M, Huang C, Sahoo MK, Pannaraj PS, O'Gorman M, Judkins AR, Gai X, Dien Bard J. Truong TT, et al. Among authors: li m. EBioMedicine. 2021 May;67:103355. doi: 10.1016/j.ebiom.2021.103355. Epub 2021 Apr 26. EBioMedicine. 2021. PMID: 33915337 Free PMC article.
SARS-CoV-2 Infections in mRNA Vaccinated Individuals are Biased for Viruses Encoding Spike E484K and Associated with Reduced Infectious Virus Loads that Correlate with Respiratory Antiviral IgG levels.
Mostafa HH, Luo CH, Morris CP, Li M, Swanson NJ, Amadi A, Gallagher N, Pekosz A. Mostafa HH, et al. Among authors: li m. medRxiv [Preprint]. 2021 Jul 7:2021.07.05.21259105. doi: 10.1101/2021.07.05.21259105. medRxiv. 2021. PMID: 34268528 Free PMC article. Updated. Preprint.
Infection with the SARS-CoV-2 Delta Variant is Associated with Higher Infectious Virus Loads Compared to the Alpha Variant in both Unvaccinated and Vaccinated Individuals.
Luo CH, Morris CP, Sachithanandham J, Amadi A, Gaston D, Li M, Swanson NJ, Schwartz M, Klein EY, Pekosz A, Mostafa HH. Luo CH, et al. Among authors: li m. medRxiv [Preprint]. 2021 Aug 20:2021.08.15.21262077. doi: 10.1101/2021.08.15.21262077. medRxiv. 2021. PMID: 34462756 Free PMC article. Updated. Preprint.
Pharmacokinetics of high-titer anti-SARS-CoV-2 human convalescent plasma in high-risk children.
Gordon O, Brosnan MK, Yoon S, Jung D, Littlefield K, Ganesan A, Caputo CA, Li M, Morgenlander WR, Henson SN, Ordonez AA, De Jesus P, Tucker EW, Peart Akindele N, Ma Z, Wilson J, Ruiz-Bedoya CA, Younger MEM, Bloch EM, Shoham S, Sullivan D, Tobian AA, Cooke KR, Larman B, Gobburu JV, Casadevall A, Pekosz A, Lederman HM, Klein SL, Jain SK. Gordon O, et al. Among authors: li m. JCI Insight. 2022 Jan 25;7(2):e151518. doi: 10.1172/jci.insight.151518. JCI Insight. 2022. PMID: 34855624 Free PMC article. Clinical Trial.
Infection With the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Delta Variant Is Associated With Higher Recovery of Infectious Virus Compared to the Alpha Variant in Both Unvaccinated and Vaccinated Individuals.
Huai Luo C, Paul Morris C, Sachithanandham J, Amadi A, Gaston DC, Li M, Swanson NJ, Schwartz M, Klein EY, Pekosz A, Mostafa HH. Huai Luo C, et al. Among authors: li m. Clin Infect Dis. 2022 Aug 24;75(1):e715-e725. doi: 10.1093/cid/ciab986. Clin Infect Dis. 2022. PMID: 34922338 Free PMC article.
A Quick Displacement of the SARS-CoV-2 variant Delta with Omicron: Unprecedented Spike in COVID-19 Cases Associated with Fewer Admissions and Comparable Upper Respiratory Viral Loads.
Fall A, Eldesouki RE, Sachithanandham J, Morris CP, Norton JM, Gaston DC, Forman M, Abdullah O, Gallagher N, Li M, Swanson NJ, Pekosz A, Klein EY, Mostafa HH. Fall A, et al. Among authors: li m. medRxiv [Preprint]. 2022 Jan 28:2022.01.26.22269927. doi: 10.1101/2022.01.26.22269927. medRxiv. 2022. PMID: 35118480 Free PMC article. Updated. Preprint.
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